SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pgp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		5 / 11 CYH A 365
SER A 139
HIS A 186
LEU A 352
ILE A 357
 None
None
6PG  A 502 ( 4.9A)
None
None
 1.17A 1ee2A-1pgpA:
8.1		 1ee2A-1pgpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		5 / 11 CYH A 365
SER A 139
HIS A 186
LEU A 352
ILE A 357
 None
None
6PG  A 502 ( 4.9A)
None
None
 1.18A 1ee2B-1pgpA:
3.4		 1ee2B-1pgpA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		3 / 3 LYS A 146
ILE A  96
THR A 108
 None
 0.85A 1rx3A-1pgpA:
2.5		 1rx3A-1pgpA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 7 ALA A 358
GLY A 356
GLY A 355
ASN A 353
 None
 0.70A 2c49B-1pgpA:
4.2		 2c49B-1pgpA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 5 ILE A 417
PRO A 418
PHE A 422
ILE A 322
 None
 1.06A 2hjhA-1pgpA:
4.4		 2hjhA-1pgpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		3 / 3 HIS A  24
ILE A 155
LEU A  17
 None
 0.74A 2kceA-1pgpA:
undetectable		 2kceA-1pgpA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 6 ILE A  97
ARG A 111
LEU A 115
LEU A  72
 None
 0.96A 2rlfA-1pgpA:
0.0
2rlfD-1pgpA:
0.0		 2rlfA-1pgpA:
7.17
2rlfD-1pgpA:
7.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 8 GLY A 144
ILE A 152
ALA A 178
HIS A 180
 None
 0.92A 2x0pA-1pgpA:
0.0		 2x0pA-1pgpA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD47_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 4 GLY A 177
GLY A 143
GLY A 174
GLY A 179
 None
 0.65A 3bogD-1pgpA:
undetectable		 3bogD-1pgpA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		5 / 12 PHE A 156
ILE A 152
MET A  60
LEU A  10
ILE A   8
 None
 1.15A 3em0B-1pgpA:
undetectable		 3em0B-1pgpA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 4 ILE A 232
PHE A 219
ILE A 197
THR A 225
 None
 1.04A 3ia4A-1pgpA:
2.6		 3ia4A-1pgpA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		5 / 10 GLY A 192
ILE A 331
PHE A 379
GLY A 337
PHE A 338
 None
 1.48A 3ko0R-1pgpA:
0.0
3ko0T-1pgpA:
undetectable		 3ko0R-1pgpA:
12.98
3ko0T-1pgpA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 5 VAL A 207
LEU A 208
ILE A 322
ALA A 408
 None
 0.73A 3n8yB-1pgpA:
undetectable		 3n8yB-1pgpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		3 / 3 GLY A 263
THR A 266
ASN A 187
 None
None
6PG  A 502 (-2.9A)
 0.71A 3v4tD-1pgpA:
0.0		 3v4tD-1pgpA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		5 / 12 GLY A 124
GLY A 100
LEU A  73
ALA A 178
PHE A 156
 None
 1.15A 3vywA-1pgpA:
2.8		 3vywA-1pgpA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		5 / 12 GLY A 124
GLY A 100
LEU A  73
ALA A 178
PHE A 156
 None
 1.22A 3vywD-1pgpA:
2.2		 3vywD-1pgpA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		3 / 3 LYS A 146
ILE A  96
THR A 108
 None
 0.84A 4gh8A-1pgpA:
2.5		 4gh8A-1pgpA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 6 ILE A 367
ASP A 193
GLY A 337
VAL A 277
 None
 1.01A 4oltA-1pgpA:
0.0		 4oltA-1pgpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 6 ILE A 367
ASP A 193
GLY A 337
VAL A 277
 None
 1.05A 4oltB-1pgpA:
0.6		 4oltB-1pgpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 8 SER A 103
ALA A  76
HIS A 180
LEU A  73
 None
 1.02A 5dzkd-1pgpA:
undetectable
5dzkr-1pgpA:
undetectable		 5dzkd-1pgpA:
17.63
5dzkr-1pgpA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 8 SER A 103
ALA A  76
HIS A 180
LEU A  73
 None
 0.99A 5dzkF-1pgpA:
undetectable
5dzkT-1pgpA:
undetectable		 5dzkF-1pgpA:
17.63
5dzkT-1pgpA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		4 / 4 ASP A  99
GLY A  77
ASP A  81
ASP A 114
 None
 1.16A 5e72A-1pgpA:
2.8		 5e72A-1pgpA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		5 / 12 LEU A  57
MET A  60
ILE A  97
ALA A  79
LEU A  72
 None
 1.23A 5ienA-1pgpA:
0.0		 5ienA-1pgpA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CE2_B_SVRB202_2
(-)		 1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE
(Ovis
aries) 		5 / 12 LEU A 352
LEU A 341
GLY A 177
GLY A 179
GLY A 126
 None
 1.13A 6ce2B-1pgpA:
undetectable		 6ce2B-1pgpA:
16.22