SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
5 / 12 ALA A 347
GLU A 350
LEU A 318
ILE A 286
LEU A 374
None
1.19A 1errB-1pgvA:
undetectable
1errB-1pgvA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
5 / 12 PHE A 326
LEU A 285
ILE A 286
ILE A 289
LEU A 305
None
0.92A 1xdkF-1pgvA:
undetectable
1xdkF-1pgvA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
5 / 12 GLU A 281
ILE A 254
ALA A 276
THR A 275
ILE A 243
None
1.35A 3ndiA-1pgvA:
undetectable
3ndiA-1pgvA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
4 / 5 SER A 264
LYS A 265
LEU A 231
ASP A 235
None
1.41A 4ifxA-1pgvA:
0.0
4ifxA-1pgvA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
4 / 5 SER A 264
LYS A 265
LEU A 231
ASP A 235
None
1.43A 4ig1A-1pgvA:
0.0
4ig1A-1pgvA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
5 / 12 GLY A 337
ASN A 338
LEU A 305
ASP A 279
ALA A 328
None
1.04A 4uckB-1pgvA:
undetectable
4uckB-1pgvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
4 / 5 SER A 264
LYS A 265
LEU A 231
ASP A 235
None
1.40A 4xdtA-1pgvA:
undetectable
4xdtA-1pgvA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
4 / 4 VAL A 340
GLU A 308
GLY A 337
LEU A 336
None
1.08A 5g5gC-1pgvA:
0.0
5g5gC-1pgvA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
5 / 12 LEU A 257
ALA A 260
GLU A 287
ILE A 286
GLU A 281
None
1.06A 5n5dB-1pgvA:
undetectable
5n5dB-1pgvA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
5 / 8 VAL A 224
ILE A 254
LEU A 257
ASN A 244
MET A 246
None
1.40A 5numA-1pgvA:
undetectable
5numA-1pgvA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
5 / 12 PHE A 326
ILE A 286
ILE A 289
SER A 322
LEU A 309
None
1.47A 5uanB-1pgvA:
undetectable
5uanB-1pgvA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
4 / 8 ILE A 286
ALA A 282
LEU A 310
ILE A 289
None
0.74A 5uihA-1pgvA:
undetectable
5uihA-1pgvA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)
1pgv TROPOMODULIN TMD-1
(Caenorhabditis
elegans)
5 / 10 LEU A 309
ILE A 258
LEU A 272
ALA A 328
GLU A 308
None
1.20A 5y7pG-1pgvA:
undetectable
5y7pG-1pgvA:
23.38