SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
5 / 9 GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
SER 2 101
None
1.03A 1gtnL-1pgw2:
1.7
1gtnM-1pgw2:
2.0
1gtnL-1pgw2:
11.68
1gtnM-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
5 / 11 GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
SER 2 101
None
1.06A 1gtnM-1pgw2:
2.0
1gtnN-1pgw2:
1.7
1gtnM-1pgw2:
11.68
1gtnN-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
5 / 10 GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
SER 2 101
None
1.07A 1gtnN-1pgw2:
1.7
1gtnO-1pgw2:
1.3
1gtnN-1pgw2:
11.68
1gtnO-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
5 / 8 GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
SER 2 101
None
0.99A 1gtnP-1pgw2:
2.0
1gtnQ-1pgw2:
0.8
1gtnP-1pgw2:
11.68
1gtnQ-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
5 / 9 GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
SER 2 101
None
1.03A 1gtnS-1pgw2:
2.0
1gtnT-1pgw2:
1.7
1gtnS-1pgw2:
11.68
1gtnT-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
5 / 10 GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
SER 2 101
None
1.04A 1gtnU-1pgw2:
2.0
1gtnV-1pgw2:
1.7
1gtnU-1pgw2:
11.68
1gtnV-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
5 / 12 SER 2 101
GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
None
1.03A 1gtnL-1pgw2:
1.3
1gtnV-1pgw2:
1.7
1gtnL-1pgw2:
11.68
1gtnV-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
3 / 3 ARG 2 240
ASP 2 321
ASN 2 270
None
0.87A 1nbhA-1pgw2:
undetectable
1nbhA-1pgw2:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
3 / 3 ARG 2 240
ASP 2 321
ASN 2 270
None
0.87A 1nbhD-1pgw2:
undetectable
1nbhD-1pgw2:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
4 / 5 ARG 2 240
ASP 2 321
ASN 2 270
TYR 2 241
None
1.13A 1nbiA-1pgw2:
0.0
1nbiA-1pgw2:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
4 / 5 ARG 2 240
ASP 2 321
ASN 2 270
TYR 2 241
None
1.14A 1nbiB-1pgw2:
0.0
1nbiB-1pgw2:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
5 / 10 GLY 2 222
ALA 1 180
THR 2 106
ILE 2 227
SER 2 101
None
1.08A 1utdQ-1pgw2:
undetectable
1utdR-1pgw2:
0.9
1utdQ-1pgw2:
11.68
1utdR-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
4 / 6 ALA 2 328
PHE 2 202
ILE 2 344
VAL 2 346
None
0.91A 2cizA-1pgw2:
undetectable
2cizA-1pgw2:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
4 / 7 SER 2 102
ILE 2 107
ILE 2  41
GLY 2 145
None
0.88A 2v0mB-1pgw2:
undetectable
2v0mB-1pgw2:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
3 / 3 ARG 2  57
ASP 2  61
ASP 2  22
None
0.66A 3jayA-1pgw2:
undetectable
3jayA-1pgw2:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
3 / 3 ARG 2  57
ASP 2  61
ASP 2  22
None
0.82A 3jb2A-1pgw2:
undetectable
3jb2A-1pgw2:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT

(Bean
pod
mottle
virus)
5 / 8 LEU 1  60
VAL 1  32
LEU 1  34
VAL 1 162
LEU 1 164
None
1.33A 3kp6A-1pgw1:
undetectable
3kp6B-1pgw1:
undetectable
3kp6A-1pgw1:
23.16
3kp6B-1pgw1:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
4 / 8 LEU 2  88
THR 2  36
GLY 2  79
PRO 2 117
None
0.95A 3ny4A-1pgw2:
undetectable
3ny4A-1pgw2:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
5 / 12 PRO 2 129
LEU 2 141
LEU 2  51
ILE 2  68
ILE 2  72
None
1.06A 4a7aB-1pgw2:
undetectable
4a7aB-1pgw2:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
4 / 7 THR 2 124
ALA 2 122
THR 2  77
VAL 2  75
None
0.79A 4ik7A-1pgw2:
undetectable
4ik7A-1pgw2:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
4 / 8 THR 2 124
ALA 2 122
THR 2  77
VAL 2  75
None
0.75A 4ik7B-1pgw2:
undetectable
4ik7B-1pgw2:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
5 / 12 ASN 1  58
GLY 2 222
ALA 2 223
PHE 1 181
VAL 1  62
None
1.43A 4ryaA-1pgw1:
undetectable
4ryaA-1pgw1:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
4 / 8 SER 2 101
GLY 2 222
ALA 1 180
THR 2 106
None
0.97A 5eevL-1pgw2:
undetectable
5eevV-1pgw2:
undetectable
5eevL-1pgw2:
11.68
5eevV-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
4 / 8 SER 2 101
GLY 2 222
ALA 1 180
THR 2 106
None
0.97A 5eewL-1pgw2:
undetectable
5eewV-1pgw2:
undetectable
5eewL-1pgw2:
11.68
5eewV-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1pgw BEAN POD MOTTLE
VIRUS SMALL (S)
SUBUNIT
BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus;
Bean
pod
mottle
virus)
4 / 8 SER 2 101
GLY 2 222
ALA 1 180
THR 2 106
None
0.98A 5ef3L-1pgw2:
2.0
5ef3V-1pgw2:
undetectable
5ef3L-1pgw2:
11.68
5ef3V-1pgw2:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
3 / 3 VAL 2 330
GLN 2 204
CYH 2 260
None
0.81A 5icxA-1pgw2:
0.0
5icxE-1pgw2:
undetectable
5icxA-1pgw2:
23.26
5icxE-1pgw2:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean
pod
mottle
virus)
4 / 4 THR 2  40
VAL 2  37
PRO 2  33
THR 2  36
None
1.39A 5mthA-1pgw2:
0.0
5mthH-1pgw2:
0.9
5mthA-1pgw2:
22.16
5mthH-1pgw2:
22.16