SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		5 / 11 GLY A 280
ARG A 205
ILE A 286
GLY A 206
THR A 238
 None
 0.99A 1jg3A-1phoA:
undetectable		 1jg3A-1phoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		5 / 11 GLY A 280
ARG A 205
ILE A 286
GLY A 206
THR A 238
 None
 0.98A 1jg3B-1phoA:
undetectable		 1jg3B-1phoA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		5 / 12 GLY A  47
GLU A  48
GLY A  57
VAL A  13
ASP A  12
 None
 1.11A 1n2xA-1phoA:
undetectable		 1n2xA-1phoA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		5 / 11 ASN A 322
THR A 241
ILE A 240
LEU A 291
THR A 238
 None
 1.38A 3bf1E-1phoA:
undetectable
3bf1F-1phoA:
undetectable		 3bf1E-1phoA:
20.71
3bf1F-1phoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		4 / 4 GLY A  59
TYR A  58
GLY A  87
ASP A  97
 None
 0.69A 3kl3A-1phoA:
undetectable		 3kl3A-1phoA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		4 / 5 ASP A 184
SER A 183
GLY A 183
ASP A 181
 None
 1.26A 3w9tB-1phoA:
undetectable		 3w9tB-1phoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		4 / 5 ASP A 184
SER A 183
GLY A 183
ASP A 181
 None
 1.27A 3w9tC-1phoA:
undetectable		 3w9tC-1phoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		3 / 3 ASP A  12
ARG A  60
LYS A  46
 None
 1.00A 3wipG-1phoA:
undetectable		 3wipG-1phoA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		3 / 3 ASN A 252
LEU A 324
PHE A 250
 None
 0.77A 4dajB-1phoA:
undetectable		 4dajB-1phoA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		5 / 8 LYS A  16
TYR A  40
ARG A  82
ASP A 113
ARG A 132
 None
 0.74A 4kr4C-1phoA:
38.4		 4kr4C-1phoA:
55.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		4 / 8 LYS A  18
TYR A  40
ARG A  42
ASP A 113
 None
 1.17A 4kr4C-1phoA:
38.4		 4kr4C-1phoA:
55.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KR8_C_DM1C401_1
(OUTER MEMBRANE
PROTEIN F)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		5 / 10 LYS A  16
TYR A  40
ARG A  82
THR A 125
ARG A 132
 None
 0.75A 4kr8C-1phoA:
40.7		 4kr8C-1phoA:
55.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		3 / 3 TYR A 106
ARG A 132
LYS A 131
 None
 1.45A 4wq5B-1phoA:
0.0		 4wq5B-1phoA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		3 / 3 ASN A 252
LEU A 324
PHE A 250
 None
 0.77A 5dsgA-1phoA:
undetectable		 5dsgA-1phoA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		5 / 12 ALA A 261
LEU A 273
ILE A 326
GLY A 280
THR A 254
 None
 1.10A 5eshA-1phoA:
undetectable		 5eshA-1phoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		5 / 10 ALA A 251
ILE A 240
GLY A 285
SER A 204
GLY A 206
 None
 1.09A 5i6xA-1phoA:
undetectable		 5i6xA-1phoA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1pho PHOSPHOPORIN
(Escherichia
coli) 		3 / 3 ALA A 251
GLN A 255
THR A 234
 None
 0.75A 5n0oA-1phoA:
undetectable		 5n0oA-1phoA:
20.42