SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1phz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 7 LEU A 385
TYR A 386
THR A 323
TRP A 326
 None
 1.37A 1afsA-1phzA:
0.0		 1afsA-1phzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 7 LEU A 385
TYR A 386
THR A 323
TRP A 326
 None
 1.37A 1afsB-1phzA:
0.0		 1afsB-1phzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		3 / 3 GLN A 126
TYR A 414
ARG A 413
 None
 0.91A 1gtbA-1phzA:
undetectable		 1gtbA-1phzA:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1J8U_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		7 / 7 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
ALA A 322
 None
 0.68A 1j8uA-1phzA:
48.7		 1j8uA-1phzA:
95.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		10 / 12 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
GLU A 330
 None
None
None
None
None
None
None
FE  A 501 ( 3.7A)
None
FE  A 501 ( 2.8A)
 0.90A 1kw0A-1phzA:
41.9		 1kw0A-1phzA:
95.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		10 / 12 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
 None
None
None
None
None
None
None
None
FE  A 501 ( 3.7A)
None
 0.84A 1kw0A-1phzA:
41.9		 1kw0A-1phzA:
95.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		9 / 12 VAL A 245
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
TRP A 326
GLU A 330
 None
None
None
None
None
FE  A 501 ( 3.7A)
None
None
FE  A 501 ( 2.8A)
 0.96A 1kw0A-1phzA:
41.9		 1kw0A-1phzA:
95.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		9 / 12 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
GLU A 286
HIS A 290
TYR A 325
GLU A 330
 None
None
None
None
None
None
FE  A 501 ( 3.7A)
None
FE  A 501 ( 2.8A)
 0.90A 1mmkA-1phzA:
41.9		 1mmkA-1phzA:
95.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		9 / 12 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
GLU A 286
HIS A 290
TYR A 325
 None
None
None
None
None
None
None
FE  A 501 ( 3.7A)
None
 0.81A 1mmkA-1phzA:
41.9		 1mmkA-1phzA:
95.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		8 / 12 VAL A 245
PHE A 254
LEU A 255
GLU A 286
HIS A 290
TYR A 325
TRP A 326
GLU A 330
 None
None
None
None
FE  A 501 ( 3.7A)
None
None
FE  A 501 ( 2.8A)
 1.01A 1mmkA-1phzA:
41.9		 1mmkA-1phzA:
95.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		10 / 11 VAL A 245
LEU A 248
LEU A 249
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
GLU A 330
 None
None
None
None
None
None
None
FE  A 501 ( 3.7A)
None
FE  A 501 ( 2.8A)
 0.86A 1mmtA-1phzA:
41.8		 1mmtA-1phzA:
95.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		10 / 11 VAL A 245
LEU A 248
LEU A 249
SER A 251
PHE A 254
LEU A 255
THR A 266
GLU A 286
HIS A 290
TYR A 325
 None
None
None
None
None
None
None
None
FE  A 501 ( 3.7A)
None
 0.80A 1mmtA-1phzA:
41.8		 1mmtA-1phzA:
95.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		3 / 3 LEU A 227
VAL A 230
LEU A 234
 None
 0.46A 1mz9B-1phzA:
undetectable		 1mz9B-1phzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 7 LEU A 258
PHE A 302
PHE A 294
PHE A 299
 None
 0.92A 1wrlE-1phzA:
undetectable
1wrlF-1phzA:
undetectable		 1wrlE-1phzA:
12.62
1wrlF-1phzA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		3 / 3 ARG A 176
GLU A 228
GLN A 226
 None
 0.95A 2p16A-1phzA:
undetectable		 2p16A-1phzA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		3 / 3 ARG A 270
THR A 193
VAL A 190
 None
 0.85A 2q64A-1phzA:
undetectable		 2q64A-1phzA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		3 / 3 PHE A 233
CYH A 217
PHE A 219
 None
 0.88A 3cr5X-1phzA:
0.5		 3cr5X-1phzA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		5 / 12 ASN A 207
LEU A 354
GLY A 289
HIS A 206
PHE A 392
 None
 1.36A 3g1uA-1phzA:
undetectable		 3g1uA-1phzA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		3 / 3 THR A 380
LYS A 150
GLU A  21
 None
 0.96A 3ijdB-1phzA:
undetectable		 3ijdB-1phzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		5 / 12 ARG A 252
GLY A 312
GLY A 307
GLY A 256
ALA A 309
 None
 0.98A 3kkzB-1phzA:
undetectable		 3kkzB-1phzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		3 / 3 SER A 303
PHE A 392
LYS A 396
 None
 0.94A 3u88A-1phzA:
undetectable		 3u88A-1phzA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		5 / 11 GLN A 383
GLU A 330
LEU A 347
PRO A 281
VAL A 379
 None
FE  A 501 ( 2.8A)
None
None
None
 1.45A 3ua5A-1phzA:
0.0		 3ua5A-1phzA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 5 LEU A 248
HIS A 285
GLU A 286
HIS A 290
 None
FE  A 501 ( 3.6A)
None
FE  A 501 ( 3.7A)
 1.19A 4a7bB-1phzA:
undetectable		 4a7bB-1phzA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 5 HIS A 170
LEU A 227
LEU A 234
ASP A 229
 None
 1.22A 4aqlA-1phzA:
undetectable		 4aqlA-1phzA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		5 / 6 LEU A 248
PHE A 254
HIS A 290
TYR A 325
GLU A 330
 None
None
FE  A 501 ( 3.7A)
None
FE  A 501 ( 2.8A)
 0.74A 4pahA-1phzA:
47.5		 4pahA-1phzA:
95.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		5 / 6 PHE A 254
HIS A 285
HIS A 290
TYR A 325
GLU A 330
 None
FE  A 501 ( 3.6A)
FE  A 501 ( 3.7A)
None
FE  A 501 ( 2.8A)
 0.57A 4pahA-1phzA:
47.5		 4pahA-1phzA:
95.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		3 / 3 GLU A 286
TYR A 325
GLU A 330
 None
None
FE  A 501 ( 2.8A)
 0.75A 4ryaA-1phzA:
undetectable		 4ryaA-1phzA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 6 LEU A 128
LEU A 255
PHE A 254
VAL A 245
 None
 1.03A 4udaA-1phzA:
undetectable		 4udaA-1phzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		5 / 12 GLY A  46
ILE A  35
GLY A  92
LEU A  98
PHE A  79
 None
 1.11A 4zdyA-1phzA:
undetectable		 4zdyA-1phzA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 7 ASP A 282
ILE A 269
GLY A 272
THR A 278
 None
 0.96A 4zxiA-1phzA:
2.1		 4zxiA-1phzA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 4 VAL A 118
ILE A  38
ASN A 426
VAL A 412
 None
 1.26A 5ajqA-1phzA:
0.5		 5ajqA-1phzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 4 TYR A 198
GLY A 352
SER A 350
LEU A 354
 None
 1.42A 5bphC-1phzA:
0.0		 5bphC-1phzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		5 / 12 GLY A  46
ILE A  35
GLY A  92
LEU A  98
PHE A  79
 None
 1.11A 5eqbA-1phzA:
undetectable		 5eqbA-1phzA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		5 / 12 GLN A 126
VAL A 421
GLY A 256
ALA A 259
LEU A 308
 None
 1.10A 5kirB-1phzA:
undetectable		 5kirB-1phzA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		3 / 3 THR A 117
SER A 110
ASP A  27
 None
 0.85A 5kvaB-1phzA:
undetectable		 5kvaB-1phzA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 4 HIS A 285
HIS A 290
TYR A 325
GLU A 330
 FE  A 501 ( 3.6A)
FE  A 501 ( 3.7A)
None
FE  A 501 ( 2.8A)
 0.58A 5pahA-1phzA:
47.1		 5pahA-1phzA:
95.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		4 / 8 HIS A 206
PHE A 294
PHE A 263
LEU A 258
 None
 1.06A 5y2tB-1phzA:
0.0		 5y2tB-1phzA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)
(Rattus
norvegicus) 		6 / 6 LEU A 248
PRO A 281
HIS A 285
HIS A 290
TYR A 325
GLU A 330
 None
None
FE  A 501 ( 3.6A)
FE  A 501 ( 3.7A)
None
FE  A 501 ( 2.8A)
 0.83A 6pahA-1phzA:
47.1		 6pahA-1phzA:
95.45