SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pie'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 8 PHE A  87
GLY A 121
LEU A  66
VAL A 149
 None
 1.20A 1gsfA-1pieA:
undetectable		 1gsfA-1pieA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 8 PHE A  87
GLY A 121
LEU A  66
VAL A 149
 None
 1.20A 1gsfB-1pieA:
undetectable		 1gsfB-1pieA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 8 PHE A  87
GLY A 121
LEU A  66
VAL A 149
 None
 1.20A 1gsfD-1pieA:
undetectable		 1gsfD-1pieA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 GLY A 347
GLU A  42
LEU A 136
ILE A  37
LEU A  39
 PO4  A 401 ( 3.9A)
GLA  A 400 (-3.4A)
None
None
None
 1.20A 1kyvA-1pieA:
undetectable
1kyvE-1pieA:
undetectable		 1kyvA-1pieA:
17.53
1kyvE-1pieA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A  39
GLY A 347
GLU A  42
LEU A 136
ILE A  37
 None
PO4  A 401 ( 3.9A)
GLA  A 400 (-3.4A)
None
None
 1.18A 1kyvC-1pieA:
undetectable
1kyvD-1pieA:
undetectable		 1kyvC-1pieA:
17.53
1kyvD-1pieA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A  39
GLY A 347
GLU A  42
LEU A 136
ILE A  37
 None
PO4  A 401 ( 3.9A)
GLA  A 400 (-3.4A)
None
None
 1.18A 1kyvD-1pieA:
undetectable
1kyvE-1pieA:
undetectable		 1kyvD-1pieA:
17.53
1kyvE-1pieA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 7 ILE A 196
ASP A 183
LEU A 182
PHE A 185
 None
PO4  A 401 ( 3.2A)
GLA  A 400 ( 4.3A)
None
 0.87A 1rtsB-1pieA:
undetectable		 1rtsB-1pieA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 5 LEU A 198
ASP A 199
GLY A 257
VAL A  51
 None
 0.90A 2aojA-1pieA:
undetectable		 2aojA-1pieA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 GLY A 342
PHE A 305
VAL A 358
ALA A 334
ALA A 343
 None
 1.44A 2avdA-1pieA:
undetectable		 2avdA-1pieA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 GLY A 342
PHE A 305
VAL A 358
ALA A 334
ALA A 343
 None
 1.32A 2avdB-1pieA:
0.0		 2avdB-1pieA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_A_NCAA1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 7 SER A 139
ARG A  36
GLN A 184
GLU A 143
 None
PO4  A 401 ( 3.5A)
None
None
 0.79A 2c8aA-1pieA:
undetectable		 2c8aA-1pieA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A  39
ILE A 219
ALA A 387
ALA A  54
LEU A 357
 None
 1.21A 2japA-1pieA:
undetectable		 2japA-1pieA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A  39
ILE A 219
ALA A 387
ALA A  54
LEU A 357
 None
 1.22A 2japB-1pieA:
undetectable		 2japB-1pieA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A  39
ILE A 219
ALA A 387
ALA A  54
LEU A 357
 None
 1.20A 2japC-1pieA:
undetectable		 2japC-1pieA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A  39
ILE A 219
ALA A 387
ALA A  54
LEU A 357
 None
 1.20A 2japD-1pieA:
undetectable		 2japD-1pieA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 8 ILE A 196
ASP A 183
LEU A 182
PHE A 185
 None
PO4  A 401 ( 3.2A)
GLA  A 400 ( 4.3A)
None
 0.92A 2tsrB-1pieA:
undetectable		 2tsrB-1pieA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 GLY A 351
GLY A 349
CYH A 353
ASP A 328
THR A 346
 None
 1.22A 2vdvE-1pieA:
undetectable		 2vdvE-1pieA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 7 LEU A 327
ALA A 348
GLY A 347
ARG A  36
 None
GLA  A 400 ( 3.6A)
PO4  A 401 ( 3.9A)
PO4  A 401 ( 3.5A)
 0.94A 2wq5A-1pieA:
undetectable		 2wq5A-1pieA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 8 LEU A 161
GLY A 188
LEU A 144
GLY A 147
ASP A 151
 None
 1.32A 2yfxA-1pieA:
undetectable		 2yfxA-1pieA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 7 ALA A 343
ALA A 356
ALA A 354
GLN A 337
 None
 0.82A 3a2qA-1pieA:
undetectable		 3a2qA-1pieA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 8 VAL A 322
ASP A 328
GLY A 351
HIS A 313
 None
 1.04A 3af0A-1pieA:
0.0		 3af0A-1pieA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 10 ALA A  54
ILE A  56
ILE A 130
PRO A 131
ILE A 187
 None
 1.01A 3clbD-1pieA:
undetectable		 3clbD-1pieA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 8 ALA A  54
ALA A 186
PRO A  53
THR A 346
 None
 0.79A 3dtuC-1pieA:
0.0
3dtuD-1pieA:
undetectable		 3dtuC-1pieA:
21.03
3dtuD-1pieA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		6 / 12 LEU A 111
ASP A  90
VAL A  92
GLY A 121
LEU A  66
ILE A 108
 None
 1.45A 3em6B-1pieA:
undetectable		 3em6B-1pieA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 10 ALA A  54
ILE A  56
ILE A 130
PRO A 131
ILE A 187
 None
 1.00A 3hbbD-1pieA:
undetectable		 3hbbD-1pieA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 ASN A  38
GLY A  41
ARG A 289
VAL A 164
GLY A 180
 None
None
None
None
GLA  A 400 (-3.9A)
 1.28A 3k13A-1pieA:
undetectable		 3k13A-1pieA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 ASN A  38
GLY A  41
ARG A 289
VAL A 164
GLY A 180
 None
None
None
None
GLA  A 400 (-3.9A)
 1.28A 3k13C-1pieA:
undetectable		 3k13C-1pieA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A 330
GLY A 342
ASN A 310
TYR A 215
ALA A 359
 None
 0.94A 3uwlB-1pieA:
0.0		 3uwlB-1pieA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A 330
GLY A 342
ASN A 310
TYR A 215
ALA A 359
 None
 0.92A 3uwlD-1pieA:
0.0		 3uwlD-1pieA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A 163
LEU A 166
GLY A 167
THR A 170
ILE A 108
 None
 1.06A 4c9lA-1pieA:
undetectable		 4c9lA-1pieA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 8 LEU A 163
LEU A 166
GLY A 167
THR A 170
 None
 0.85A 4c9nA-1pieA:
undetectable		 4c9nA-1pieA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A 163
LEU A 166
GLY A 167
THR A 170
ILE A 108
 None
 0.99A 4c9oA-1pieA:
undetectable		 4c9oA-1pieA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A 163
LEU A 166
GLY A 167
THR A 170
ILE A 108
 None
 1.00A 4c9oB-1pieA:
undetectable		 4c9oB-1pieA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		3 / 3 PHE A  22
ASP A  24
ARG A  65
 None
 0.84A 4eahF-1pieA:
undetectable		 4eahF-1pieA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		3 / 3 PHE A  22
ASP A  24
ARG A  65
 None
 0.84A 4eahG-1pieA:
undetectable		 4eahG-1pieA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 GLU A 206
GLY A 190
PHE A  52
LEU A  39
ILE A  56
 None
 1.16A 4hytA-1pieA:
undetectable		 4hytA-1pieA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 GLU A 206
GLY A 190
PHE A  52
LEU A  39
ILE A  56
 None
 1.18A 4hytC-1pieA:
undetectable		 4hytC-1pieA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 7 ARG A 236
GLY A 349
GLY A 324
GLU A 326
 None
 0.89A 4koeA-1pieA:
undetectable
4koeB-1pieA:
2.6
4koeD-1pieA:
undetectable		 4koeA-1pieA:
23.79
4koeB-1pieA:
23.79
4koeD-1pieA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 THR A  44
GLY A  48
ASN A 201
HIS A 282
SER A 315
 None
 1.09A 4pooA-1pieA:
undetectable		 4pooA-1pieA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 THR A  44
GLY A  48
ASN A 201
HIS A 282
SER A 315
 None
 1.05A 4pooB-1pieA:
undetectable		 4pooB-1pieA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 6 ASN A 172
GLU A 230
TYR A  46
PHE A 237
 None
None
GLA  A 400 (-4.5A)
None
 1.06A 4twdG-1pieA:
1.2
4twdH-1pieA:
0.0		 4twdG-1pieA:
23.00
4twdH-1pieA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 5 GLY A  41
THR A 290
GLY A  49
GLU A 286
 None
 1.15A 4v20A-1pieA:
undetectable		 4v20A-1pieA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 5 GLY A 128
THR A  60
GLY A  35
GLU A 129
 None
 1.11A 4v20A-1pieA:
undetectable		 4v20A-1pieA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB101_2
(CHROMOBOX PROTEIN
HOMOLOG 7)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 10 ARG A 281
LEU A 256
THR A 240
HIS A  43
LEU A 182
 None
None
None
GLA  A 400 (-3.6A)
GLA  A 400 ( 4.3A)
 1.28A 4x3uB-1pieA:
undetectable		 4x3uB-1pieA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 7 ARG A 236
GLY A 349
GLY A 324
GLU A 326
 None
 0.91A 4z53A-1pieA:
2.7
4z53B-1pieA:
undetectable		 4z53A-1pieA:
17.49
4z53B-1pieA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 7 ALA A 387
ASP A 183
GLY A 347
THR A  44
 None
PO4  A 401 ( 3.2A)
PO4  A 401 ( 3.9A)
None
 1.03A 5bs8A-1pieA:
2.3
5bs8B-1pieA:
undetectable
5bs8C-1pieA:
2.2		 5bs8A-1pieA:
24.86
5bs8B-1pieA:
21.58
5bs8C-1pieA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 7 ALA A 387
ASP A 183
GLY A 347
THR A  44
 None
PO4  A 401 ( 3.2A)
PO4  A 401 ( 3.9A)
None
 1.03A 5btdA-1pieA:
2.2
5btdB-1pieA:
undetectable
5btdC-1pieA:
2.2		 5btdA-1pieA:
24.86
5btdB-1pieA:
21.58
5btdC-1pieA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 GLY A 390
SER A 391
CYH A 353
LEU A 136
PRO A 131
 None
 1.12A 5ergB-1pieA:
undetectable		 5ergB-1pieA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 8 GLY A 121
LEU A  89
VAL A  92
ILE A 118
LEU A 150
 None
 1.25A 5vkqB-1pieA:
2.1
5vkqC-1pieA:
2.1		 5vkqB-1pieA:
12.75
5vkqC-1pieA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 10 LEU A 136
ILE A 355
PHE A  52
ALA A 186
LEU A 182
 None
None
None
None
GLA  A 400 ( 4.3A)
 1.27A 5y7pG-1pieA:
0.0		 5y7pG-1pieA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		4 / 6 GLN A 165
VAL A 158
MET A 207
ARG A  36
 None
None
None
PO4  A 401 ( 3.5A)
 1.25A 6brdB-1pieA:
0.1		 6brdB-1pieA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A 136
ILE A  58
GLY A  59
ILE A  37
ILE A  56
 None
 1.00A 6emuA-1pieA:
undetectable		 6emuA-1pieA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 11 GLY A 347
GLY A 349
LEU A 316
VAL A 322
ASP A  45
 PO4  A 401 ( 3.9A)
None
None
None
GLA  A 400 (-2.8A)
 1.09A 6i5zD-1pieA:
undetectable		 6i5zD-1pieA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 1pie GALACTOKINASE
(Lactococcus
lactis) 		5 / 12 LEU A 330
GLY A 342
ASN A 310
TYR A 215
ALA A 359
 None
 0.95A 6qyaD-1pieA:
0.0		 6qyaD-1pieA:
21.36