SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		4 / 7 SER A  85
VAL A 180
GLY A 182
ILE A 212
 None
 0.74A 1gtnC-1piiA:
undetectable
1gtnD-1piiA:
undetectable		 1gtnC-1piiA:
9.61
1gtnD-1piiA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		4 / 8 GLY A 265
LEU A 281
ARG A 264
GLY A 261
 None
 0.74A 1jhvA-1piiA:
undetectable		 1jhvA-1piiA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		4 / 6 LEU A 135
ASP A 115
ILE A   8
GLU A 163
 None
 1.08A 1mt1A-1piiA:
undetectable
1mt1F-1piiA:
undetectable		 1mt1A-1piiA:
7.73
1mt1F-1piiA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		3 / 3 ASP A  41
TYR A  40
GLU A 157
 None
 0.84A 1vm1A-1piiA:
undetectable		 1vm1A-1piiA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		5 / 12 TYR A  92
LEU A 191
ILE A   8
PHE A 116
SER A 139
 None
 1.47A 1xmuA-1piiA:
undetectable		 1xmuA-1piiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		5 / 12 TYR A  92
LEU A 191
ILE A   8
PHE A 116
SER A 139
 None
 1.50A 1xmuB-1piiA:
undetectable		 1xmuB-1piiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		3 / 3 ASN A 313
HIS A 314
VAL A 319
 None
 0.86A 3elzB-1piiA:
0.0		 3elzB-1piiA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		4 / 6 LEU A 234
GLU A 214
ASN A 184
SER A  85
 None
 1.26A 3i9jB-1piiA:
undetectable		 3i9jB-1piiA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		4 / 8 LEU A 188
LEU A 135
ILE A   8
PHE A 116
 None
 0.84A 3ln1A-1piiA:
undetectable		 3ln1A-1piiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		4 / 7 LEU A 188
LEU A 135
ILE A   8
PHE A 116
 None
 0.84A 3ln1B-1piiA:
undetectable		 3ln1B-1piiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		3 / 3 ARG A 368
LEU A 378
THR A 419
 None
 0.80A 3oxcA-1piiA:
undetectable		 3oxcA-1piiA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		5 / 12 TYR A 452
GLY A 232
SER A 227
ILE A 217
LEU A  43
 None
 1.22A 3q87B-1piiA:
undetectable		 3q87B-1piiA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_A_KANA304_1
(APH(2'')-ID)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		5 / 10 ASP A 187
SER A 165
ASP A 190
GLU A 168
GLU A 169
 None
 1.36A 3sg9A-1piiA:
0.0		 3sg9A-1piiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		3 / 3 ARG A 251
ASP A 243
ASP A  66
 None
 0.91A 4kicB-1piiA:
0.2		 4kicB-1piiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		3 / 3 ARG A 197
LEU A 201
GLU A 200
 None
 0.73A 4l3gF-1piiA:
undetectable		 4l3gF-1piiA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		4 / 8 VAL A 284
GLY A 383
PRO A 288
ILE A 282
 None
 0.67A 4ll3A-1piiA:
undetectable		 4ll3A-1piiA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		4 / 8 GLU A  53
GLU A 214
GLU A 163
TYR A  92
 None
 1.11A 4mj8A-1piiA:
0.0
4mj8C-1piiA:
1.1		 4mj8A-1piiA:
15.38
4mj8C-1piiA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		3 / 3 PHE A  68
ILE A  73
ASP A 244
 None
 0.62A 5cswA-1piiA:
undetectable		 5cswA-1piiA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		3 / 3 PHE A  68
ILE A  73
ASP A 244
 None
 0.57A 5cswB-1piiA:
undetectable		 5cswB-1piiA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		4 / 5 ILE A  73
ARG A  65
CYH A  54
GLU A  53
 None
 1.43A 5fseC-1piiA:
1.3		 5fseC-1piiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		4 / 6 VAL A 319
LYS A 322
ALA A 323
VAL A 331
 None
 0.94A 5i8fA-1piiA:
0.0		 5i8fA-1piiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE
(Escherichia
coli) 		3 / 3 VAL A 377
ALA A 405
GLN A 332
 None
 0.65A 6gb9A-1piiA:
undetectable		 6gb9A-1piiA:
21.61