SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		5 / 9 TYR A  68
LEU A 169
ILE A 139
VAL A 148
ILE A  75
 None
 1.35A 1gebA-1pioA:
undetectable		 1gebA-1pioA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		11 / 12 ALA A  69
SER A  70
LYS A  73
TYR A 105
SER A 130
ASN A 132
ILE A 167
LYS A 234
SER A 235
GLY A 236
ARG A 244
 None
 0.68A 1ghmA-1pioA:
44.7		 1ghmA-1pioA:
98.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		8 / 12 ALA A  69
SER A  70
LYS A  73
SER A 130
ASN A 132
GLU A 166
LYS A 234
GLY A 236
 None
 0.75A 1i2wA-1pioA:
40.5		 1i2wA-1pioA:
40.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1I2W_B_CFXB2300_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		8 / 12 ALA A  69
SER A  70
LYS A  73
SER A 130
ASN A 132
GLU A 166
GLY A 236
ARG A 244
 None
 0.67A 1i2wB-1pioA:
40.7		 1i2wB-1pioA:
40.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 LYS A  73
SER A 130
ASN A 132
GLU A 166
ASN A 170
LYS A 234
GLY A 236
 None
 0.95A 1ymxA-1pioA:
37.8		 1ymxA-1pioA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
 None
 0.79A 1ymxA-1pioA:
37.8		 1ymxA-1pioA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 LYS A  73
SER A 130
ASN A 132
GLU A 166
ASN A 170
LYS A 234
GLY A 236
 None
 0.94A 1ymxB-1pioA:
37.9		 1ymxB-1pioA:
33.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YMX_B_CFXB1002_1
(BETA-LACTAMASE
CTX-M-9)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 SER A  70
LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
 None
 0.78A 1ymxB-1pioA:
37.9		 1ymxB-1pioA:
33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_A_ANWA99_0
(PROTEIN S100-A13)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		4 / 7 VAL A 159
THR A 160
THR A 180
LYS A  64
 None
 1.25A 2kotA-1pioA:
0.0		 2kotA-1pioA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		5 / 10 VAL A  95
ILE A 102
ILE A 108
PRO A 107
ILE A 117
 None
 1.26A 3hbbD-1pioA:
0.0		 3hbbD-1pioA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_C_DX2C270_1
(PTERIDINE REDUCTASE
1)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		4 / 8 SER A 106
ASP A 101
VAL A  95
LEU A 119
 None
 1.06A 3jq7C-1pioA:
undetectable		 3jq7C-1pioA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		6 / 12 ALA A  69
SER A  70
LYS A  73
ASN A 132
GLY A 236
ARG A 244
 None
 0.88A 3mzeA-1pioA:
21.0		 3mzeA-1pioA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3Q07_A_WPPA300_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		6 / 12 LYS A  73
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
 None
 0.77A 3q07A-1pioA:
37.7		 3q07A-1pioA:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_A_CEDA1_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 ALA A  69
SER A  70
SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 244
 None
 0.78A 3sh8A-1pioA:
38.5		 3sh8A-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SH8_B_CEDB1_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		8 / 12 ALA A  69
SER A  70
LYS A  73
SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 244
 None
 0.78A 3sh8B-1pioA:
38.6		 3sh8B-1pioA:
43.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		5 / 12 ILE A  75
GLY A 187
PHE A 186
ILE A 194
ALA A 195
 None
 0.98A 3uwlB-1pioA:
undetectable		 3uwlB-1pioA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FH2_A_0RNA303_1
(BETA-LACTAMASE SHV-1)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		5 / 10 SER A 130
ASN A 132
LYS A 234
GLY A 236
ARG A 244
 None
 0.84A 4fh2A-1pioA:
32.2		 4fh2A-1pioA:
29.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9K_A_CEDA301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		8 / 12 ALA A  69
SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ARG A 244
 None
 0.72A 4n9kA-1pioA:
40.4		 4n9kA-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4N9K_B_CEDB301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		8 / 12 ALA A  69
SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ARG A 244
 None
 0.74A 4n9kB-1pioA:
40.4		 4n9kB-1pioA:
43.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		3 / 3 ASP A 268
HIS A  43
LYS A 267
 None
 1.00A 4qzuD-1pioA:
0.8		 4qzuD-1pioA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		5 / 12 GLY A 236
SER A  72
LEU A 190
PHE A 264
LEU A 169
 None
 1.39A 4xldA-1pioA:
undetectable		 4xldA-1pioA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		4 / 8 ILE A 123
LEU A 119
LEU A  81
ILE A 138
 None
 0.80A 4zvcA-1pioA:
0.0
4zvcB-1pioA:
0.0		 4zvcA-1pioA:
17.44
4zvcB-1pioA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		4 / 8 ILE A 138
ILE A 123
LEU A 119
LEU A  81
 None
 0.80A 4zvcA-1pioA:
0.0
4zvcB-1pioA:
0.0		 4zvcA-1pioA:
17.44
4zvcB-1pioA:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 ALA A  69
SER A  70
SER A 130
ASN A 132
ASN A 170
GLY A 236
ARG A 244
 None
 0.74A 5ghyA-1pioA:
40.0		 5ghyA-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 ALA A  69
SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
ARG A 244
 None
 0.81A 5ghyA-1pioA:
40.0		 5ghyA-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 ALA A  69
SER A  70
TYR A 105
SER A 130
ASN A 132
ASN A 170
GLY A 236
 None
 0.79A 5ghyA-1pioA:
40.0		 5ghyA-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_A_CEDA301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 ALA A  69
SER A  70
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
 None
 0.83A 5ghyA-1pioA:
40.0		 5ghyA-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 ALA A  69
SER A  70
SER A 130
ASN A 132
ASN A 170
GLY A 236
ARG A 244
 None
 0.73A 5ghyB-1pioA:
40.3		 5ghyB-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 ALA A  69
SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
ARG A 244
 None
 0.79A 5ghyB-1pioA:
40.3		 5ghyB-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 ALA A  69
SER A  70
TYR A 105
SER A 130
ASN A 132
ASN A 170
GLY A 236
 None
 0.79A 5ghyB-1pioA:
40.3		 5ghyB-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHY_B_CEDB301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 12 ALA A  69
SER A  70
TYR A 105
SER A 130
ASN A 132
ASN A 170
LYS A 234
 None
 0.84A 5ghyB-1pioA:
40.3		 5ghyB-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		8 / 11 ALA A  69
SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ARG A 244
 None
 0.76A 5ghzA-1pioA:
40.2		 5ghzA-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_A_CEDA301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		7 / 11 ALA A  69
SER A  70
TYR A 105
ASN A 132
ASN A 170
GLY A 236
ARG A 244
 None
 1.39A 5ghzA-1pioA:
40.2		 5ghzA-1pioA:
43.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5GHZ_B_CEDB301_1
(BETA-LACTAMASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		8 / 10 ALA A  69
SER A  70
SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
ARG A 244
 None
 0.76A 5ghzB-1pioA:
40.1		 5ghzB-1pioA:
43.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		5 / 12 ILE A  75
GLY A 187
PHE A 186
ILE A 194
ALA A 195
 None
 0.93A 5j7wD-1pioA:
undetectable		 5j7wD-1pioA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		5 / 10 PRO A 162
ILE A  75
ILE A 139
ILE A 142
ILE A 138
 None
 1.09A 5murE-1pioA:
undetectable		 5murE-1pioA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 1pio BETA-LACTAMASE
(Staphylococcus
aureus) 		5 / 12 SER A 130
ASN A 132
ASN A 170
LYS A 234
GLY A 236
 None
 0.77A 6c79A-1pioA:
37.6		 6c79A-1pioA:
20.74