SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 7 GLY A 378
TYR A 371
ALA A 377
GLU A 373
 None
 0.75A 1dmaA-1pixA:
undetectable		 1dmaA-1pixA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_2
(PROTEASE RETROPEPSIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.79A 1rl8B-1pixA:
undetectable		 1rl8B-1pixA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.84A 2f8gB-1pixA:
undetectable		 2f8gB-1pixA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 9 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.82A 2idwB-1pixA:
undetectable		 2idwB-1pixA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.84A 2ienA-1pixA:
undetectable		 2ienA-1pixA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.85A 2nmzA-1pixA:
undetectable		 2nmzA-1pixA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.84A 2nmzB-1pixA:
undetectable		 2nmzB-1pixA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 6 ARG A 164
PHE A  82
GLN A  85
PRO A  84
 None
 1.47A 2qqtA-1pixA:
0.0		 2qqtA-1pixA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQT_A_AINA596_1
(LACTOPEROXIDASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 6 GLU A 126
PHE A  82
GLN A  85
PRO A  84
 None
 1.37A 2qqtA-1pixA:
0.0		 2qqtA-1pixA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.87A 2rkfB-1pixA:
undetectable		 2rkfB-1pixA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 8 GLN A 466
GLY A 464
GLY A 416
MET A 394
 None
 0.95A 2y6rB-1pixA:
undetectable		 2y6rB-1pixA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 GLY A 476
LEU A 537
HIS A 459
PRO A 465
ILE A 482
 None
 1.02A 2y7kD-1pixA:
undetectable		 2y7kD-1pixA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.86A 3bvbB-1pixA:
undetectable		 3bvbB-1pixA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 VAL A 538
GLU A 448
GLY A 464
ILE A 436
GLN A 440
 None
 1.41A 3bwyA-1pixA:
undetectable		 3bwyA-1pixA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 8 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.79A 3ekpA-1pixA:
undetectable		 3ekpA-1pixA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 10 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.78A 3ekpD-1pixA:
undetectable		 3ekpD-1pixA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_D_017D200_1
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 11 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.79A 3ektC-1pixA:
undetectable		 3ektC-1pixA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 10 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.88A 3ekvA-1pixA:
undetectable		 3ekvA-1pixA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 10 VAL A 108
ILE A 205
VAL A 282
VAL A 101
LEU A  69
 None
 0.92A 3gwxA-1pixA:
0.0		 3gwxA-1pixA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.89A 3jw2A-1pixA:
undetectable		 3jw2A-1pixA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.84A 3k4vA-1pixA:
undetectable		 3k4vA-1pixA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.83A 3lzuB-1pixA:
undetectable		 3lzuB-1pixA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.80A 3ndtA-1pixA:
undetectable		 3ndtA-1pixA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.84A 3ndtB-1pixA:
undetectable		 3ndtB-1pixA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 11 GLY A 343
GLU A 345
LEU A 386
ASN A 363
LEU A 391
 None
 1.38A 3ndvA-1pixA:
0.0
3ndvB-1pixA:
0.0		 3ndvA-1pixA:
24.09
3ndvB-1pixA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 11 GLY A 343
GLU A 345
LEU A 386
ASN A 363
LEU A 391
 None
 1.39A 3ndvC-1pixA:
0.0
3ndvD-1pixA:
0.0		 3ndvC-1pixA:
24.09
3ndvD-1pixA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 11 LEU A 391
GLY A 343
GLU A 345
LEU A 386
ASN A 363
 None
 1.39A 3ndvC-1pixA:
0.0
3ndvD-1pixA:
0.0		 3ndvC-1pixA:
24.09
3ndvD-1pixA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 9 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.90A 3nujB-1pixA:
undetectable		 3nujB-1pixA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 9 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.89A 3oxvA-1pixA:
undetectable		 3oxvA-1pixA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 7 LYS A 393
VAL A 409
LEU A 462
MET A 346
 None
 0.95A 3rgfA-1pixA:
undetectable		 3rgfA-1pixA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.89A 3s54A-1pixA:
undetectable		 3s54A-1pixA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.88A 3tkwB-1pixA:
undetectable		 3tkwB-1pixA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.84A 3tl9A-1pixA:
undetectable		 3tl9A-1pixA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.83A 3tl9B-1pixA:
undetectable		 3tl9B-1pixA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 6 ASP A 418
GLU A 424
GLY A 420
LEU A 428
 None
 1.16A 3w9tB-1pixA:
undetectable		 3w9tB-1pixA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 6 ASP A 418
GLU A 424
GLY A 420
LEU A 428
 None
 1.14A 3w9tE-1pixA:
0.0		 3w9tE-1pixA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 6 ASP A 418
GLU A 424
GLY A 420
LEU A 428
 None
 1.15A 3w9tF-1pixA:
undetectable		 3w9tF-1pixA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 ASP A 413
VAL A 312
ILE A 322
VAL A 360
LEU A 308
 None
 1.35A 4a84A-1pixA:
undetectable		 4a84A-1pixA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 6 GLY A 378
TYR A 371
ALA A 377
GLU A 373
 None
 0.64A 4ae1A-1pixA:
undetectable		 4ae1A-1pixA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 10 GLY A  99
ALA A 110
VAL A 108
SER A  74
VAL A 101
 None
 1.05A 4da7A-1pixA:
3.0		 4da7A-1pixA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 10 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.81A 4dqfB-1pixA:
undetectable		 4dqfB-1pixA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E47_B_SAMB800_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 11 ILE A 411
ALA A 362
GLU A 337
GLY A 366
TYR A 320
 None
 1.27A 4e47B-1pixA:
undetectable		 4e47B-1pixA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 8 LYS A 385
ILE A 382
MET A 346
GLY A 390
 None
 0.94A 4hdlA-1pixA:
0.0		 4hdlA-1pixA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J83_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 11 ILE A 411
ALA A 362
GLU A 337
GLY A 383
TYR A 320
 None
 1.45A 4j83A-1pixA:
0.0		 4j83A-1pixA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 11 ILE A 411
ALA A 362
GLU A 337
GLY A 366
TYR A 320
 None
 1.28A 4jdsA-1pixA:
undetectable		 4jdsA-1pixA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JDS_B_SAMB401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 11 ILE A 411
ALA A 362
GLU A 337
GLY A 366
TYR A 320
 None
 1.28A 4jdsB-1pixA:
undetectable		 4jdsB-1pixA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_2
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 10 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.80A 4ll3B-1pixA:
undetectable		 4ll3B-1pixA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 10 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.82A 4ll3A-1pixA:
undetectable		 4ll3A-1pixA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 8 TYR A 437
ILE A 436
VAL A 398
THR A 399
 None
 0.90A 4ma7A-1pixA:
undetectable		 4ma7A-1pixA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		6 / 11 GLY A 277
VAL A 143
GLY A 283
PRO A 182
THR A 203
ILE A 184
 None
 1.48A 4njvC-1pixA:
undetectable		 4njvC-1pixA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 8 LEU A 142
VAL A 282
LEU A 285
GLY A 180
 None
 0.84A 4r3aA-1pixA:
undetectable		 4r3aA-1pixA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 ILE A 411
ILE A 449
ILE A 547
LEU A 335
PHE A 330
 None
 1.08A 4y0pA-1pixA:
1.7		 4y0pA-1pixA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 6 TYR A 323
ILE A 411
VAL A 347
ALA A 362
 None
 0.75A 5cu6A-1pixA:
undetectable		 5cu6A-1pixA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.84A 5e5kA-1pixA:
undetectable		 5e5kA-1pixA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		3 / 3 TRP A 410
ILE A 444
SER A 442
 None
 0.96A 5gqbA-1pixA:
2.7		 5gqbA-1pixA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 VAL A 409
GLN A 446
VAL A 358
SER A 442
LEU A  98
 None
 1.22A 5hv1A-1pixA:
0.0		 5hv1A-1pixA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 11 ASP A 321
ALA A 362
LYS A 393
GLU A 337
VAL A 360
 None
 1.29A 5hw4B-1pixA:
undetectable		 5hw4B-1pixA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		3 / 3 LYS A 526
GLN A  85
ASN A  83
 None
 1.07A 5l2tA-1pixA:
0.8		 5l2tA-1pixA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 10 ALA A 351
VAL A 360
ILE A 449
ILE A 547
VAL A 325
 None
 1.13A 5nukA-1pixA:
1.7		 5nukA-1pixA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 7 TYR A 323
ILE A 411
VAL A 347
ALA A 362
 None
 0.77A 5ospA-1pixA:
undetectable		 5ospA-1pixA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		4 / 7 TYR A 323
ILE A 411
VAL A 347
ALA A 362
 None
 0.74A 5osrA-1pixA:
0.1		 5osrA-1pixA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_2
(PROTEASE)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 LEU A 146
GLY A 189
ALA A 211
GLY A 252
ILE A 187
 None
 0.77A 5t2zB-1pixA:
undetectable		 5t2zB-1pixA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		3 / 3 TYR A 320
ALA A 479
LEU A 451
 None
 0.52A 6d9kF-1pixA:
1.8		 6d9kF-1pixA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 GLY A  99
VAL A 143
ARG A 100
GLN A 560
PRO A 141
 None
 1.13A 6gneA-1pixA:
3.8		 6gneA-1pixA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1pix GLUTACONYL-COA
DECARBOXYLASE A
SUBUNIT
(Acidaminococcus
fermentans) 		5 / 12 GLY A  99
VAL A 143
ARG A 100
GLN A 560
PRO A 141
 None
 1.13A 6gneB-1pixA:
3.8		 6gneB-1pixA:
22.65