SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 7 GLU A 298
LEU A 301
VAL A  39
LEU A  56
 None
 0.96A 1hk3A-1pjaA:
undetectable		 1hk3A-1pjaA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 5 LEU A 195
TRP A 210
LEU A  83
GLN A 139
 None
 1.45A 1p93D-1pjaA:
0.0		 1p93D-1pjaA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		5 / 12 LEU A 195
ASN A 177
ILE A 175
SER A 111
GLN A 112
 None
None
None
GOL  A1616 (-3.4A)
None
 1.31A 1xlxA-1pjaA:
undetectable		 1xlxA-1pjaA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		5 / 12 LEU A 115
LEU A  83
TYR A 178
ASP A 185
ALA A 196
 None
 1.07A 2bm9A-1pjaA:
3.9		 2bm9A-1pjaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		5 / 12 LEU A 115
LEU A  83
TYR A 178
ASP A 185
ALA A 196
 None
 1.16A 2br4E-1pjaA:
3.2		 2br4E-1pjaA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		5 / 12 LEU A 115
LEU A  83
TYR A 178
ASP A 185
ALA A 196
 None
 1.12A 2br4F-1pjaA:
3.1		 2br4F-1pjaA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 7 SER A 111
LEU A  45
GLY A 229
ASP A 228
 GOL  A1616 (-3.4A)
GOL  A1616 ( 4.9A)
None
None
 0.91A 2ddwB-1pjaA:
4.8		 2ddwB-1pjaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		3 / 3 GLY A  44
ASP A  47
SER A  79
 None
 0.73A 2qhfA-1pjaA:
undetectable		 2qhfA-1pjaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 6 LEU A  45
PHE A  46
LEU A  80
PHE A 173
 GOL  A1616 ( 4.9A)
None
None
None
 0.90A 3abkP-1pjaA:
undetectable
3abkW-1pjaA:
undetectable		 3abkP-1pjaA:
22.12
3abkW-1pjaA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 8 LEU A  45
PHE A  46
LEU A  80
PHE A 173
 GOL  A1616 ( 4.9A)
None
None
None
 0.88A 3asoC-1pjaA:
undetectable
3asoJ-1pjaA:
undetectable		 3asoC-1pjaA:
22.12
3asoJ-1pjaA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 5 VAL A 274
VAL A 221
GLN A 139
ARG A 118
 None
 1.20A 3bjwH-1pjaA:
0.0		 3bjwH-1pjaA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 6 VAL A 274
VAL A 221
GLN A 139
ARG A 118
 None
 1.25A 3bjwF-1pjaA:
0.0		 3bjwF-1pjaA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 8 GLY A 114
GLY A 113
GLY A  44
SER A 137
 None
 0.59A 3d41A-1pjaA:
undetectable		 3d41A-1pjaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 7 LEU A  45
PHE A  46
LEU A  80
PHE A 173
 GOL  A1616 ( 4.9A)
None
None
None
 0.88A 5b1aC-1pjaA:
undetectable
5b1aJ-1pjaA:
undetectable		 5b1aC-1pjaA:
22.12
5b1aJ-1pjaA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 7 LEU A  45
PHE A  46
LEU A  80
PHE A 173
 GOL  A1616 ( 4.9A)
None
None
None
 0.89A 5b1aP-1pjaA:
undetectable
5b1aW-1pjaA:
undetectable		 5b1aP-1pjaA:
22.12
5b1aW-1pjaA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 7 LEU A  45
PHE A  46
LEU A  80
PHE A 173
 GOL  A1616 ( 4.9A)
None
None
None
 0.87A 5iy5C-1pjaA:
undetectable
5iy5J-1pjaA:
undetectable		 5iy5C-1pjaA:
21.82
5iy5J-1pjaA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 5 LEU A  45
PHE A  46
LEU A  80
PHE A 173
 GOL  A1616 ( 4.9A)
None
None
None
 0.91A 5x19C-1pjaA:
undetectable
5x19J-1pjaA:
undetectable		 5x19C-1pjaA:
22.12
5x19J-1pjaA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		5 / 12 PHE A 214
LEU A 195
VAL A 116
GLY A 114
LEU A 220
 None
 1.24A 5x24A-1pjaA:
undetectable		 5x24A-1pjaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1pja PALMITOYL-PROTEIN
THIOESTERASE 2
PRECURSOR
(Homo
sapiens) 		4 / 5 GLY A  44
SER A 174
TYR A 178
GLN A 112
 None
 1.30A 6ji6A-1pjaA:
undetectable		 6ji6A-1pjaA:
21.45