SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pjb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		3 / 3 THR A 309
LEU A 312
LEU A 129
 None
 0.66A 1mz9C-1pjbA:
undetectable		 1mz9C-1pjbA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		5 / 12 MET A  69
LEU A  89
GLN A 344
VAL A 343
LEU A 331
 None
 1.20A 1nhzA-1pjbA:
undetectable		 1nhzA-1pjbA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		4 / 6 GLY A   4
VAL A  58
ALA A  64
SER A  66
 None
 0.79A 1p6kA-1pjbA:
undetectable		 1p6kA-1pjbA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		3 / 3 THR A 309
THR A 307
PRO A 305
 None
 0.80A 1qfiB-1pjbA:
undetectable		 1qfiB-1pjbA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		3 / 3 THR A 307
PRO A 305
THR A 309
 None
 0.64A 209dC-1pjbA:
undetectable		 209dC-1pjbA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		4 / 8 GLU A 117
HIS A 350
ASN A 342
ILE A 114
 None
 1.24A 3kp6A-1pjbA:
undetectable
3kp6B-1pjbA:
undetectable		 3kp6A-1pjbA:
16.22
3kp6B-1pjbA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		3 / 3 PHE A  45
SER A  21
GLN A 310
 None
 0.95A 3smtA-1pjbA:
undetectable		 3smtA-1pjbA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		5 / 10 GLY A 340
VAL A 119
GLU A 120
ASN A 342
ILE A 114
 None
 1.39A 3uayA-1pjbA:
undetectable		 3uayA-1pjbA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		4 / 6 GLU A   8
LYS A  72
LYS A   7
GLU A  36
 None
 1.37A 4a7tF-1pjbA:
0.0		 4a7tF-1pjbA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		3 / 3 ARG A  15
ASP A 269
GLN A 270
 None
 0.73A 4azsA-1pjbA:
8.1		 4azsA-1pjbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		3 / 3 VAL A  23
TYR A  50
ALA A  53
 None
 0.51A 4ybnA-1pjbA:
0.0		 4ybnA-1pjbA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		4 / 6 ALA A 136
SER A 133
GLN A 270
ASP A 265
 None
 0.89A 5c6pA-1pjbA:
0.0		 5c6pA-1pjbA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		4 / 6 LEU A 323
LEU A 317
PHE A  91
LEU A 128
 None
 0.92A 5gs4A-1pjbA:
0.0		 5gs4A-1pjbA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		4 / 6 HIS A 350
GLU A 117
LEU A  89
TYR A 319
 None
 1.06A 5igiA-1pjbA:
undetectable		 5igiA-1pjbA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		5 / 10 PRO A 246
GLY A 236
GLY A 174
VAL A 240
ALA A 267
 None
 1.09A 5o96E-1pjbA:
3.8
5o96F-1pjbA:
undetectable		 5o96E-1pjbA:
21.72
5o96F-1pjbA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		5 / 8 LEU A 253
VAL A 249
VAL A 228
ILE A 263
ASP A 265
 None
 1.46A 5y9mA-1pjbA:
undetectable		 5y9mA-1pjbA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1pjb L-ALANINE
DEHYDROGENASE
(Phormidium
lapideum) 		4 / 6 PHE A  45
ALA A  43
THR A 316
ASN A 314
 None
 0.96A 6f88A-1pjbA:
undetectable		 6f88A-1pjbA:
12.54