SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pjm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 GLU B 306
ILE B 309
LEU B 302
GLY B 303
ALA B 355
 None
 1.16A 1hvyA-1pjmB:
undetectable		 1hvyA-1pjmB:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		3 / 3 LEU B 307
VAL B 310
LEU B 314
 None
 0.43A 1mz9B-1pjmB:
undetectable		 1mz9B-1pjmB:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 PHE B 127
PHE B 167
LEU B 144
ALA B  99
ALA B 100
 None
 1.31A 1q23A-1pjmB:
undetectable
1q23B-1pjmB:
undetectable		 1q23A-1pjmB:
18.36
1q23B-1pjmB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		3 / 3 LEU B 144
PHE B 124
ARG B 106
 None
 0.63A 1xdkB-1pjmB:
undetectable		 1xdkB-1pjmB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		3 / 3 LEU B 144
PHE B 124
ARG B 106
 None
 0.63A 1xdkF-1pjmB:
0.2		 1xdkF-1pjmB:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 7 LEU B 186
GLY B 161
VAL B 200
ILE B 189
 None
 0.76A 2aojB-1pjmB:
undetectable		 2aojB-1pjmB:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		3 / 3 GLN B 327
LYS B 291
VAL B 289
 None
 0.93A 2jfaB-1pjmB:
undetectable		 2jfaB-1pjmB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_2
(PROTEASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 GLY B 335
ALA B 336
GLY B 303
ALA B 316
ILE B 317
 None
 0.81A 2nmyB-1pjmB:
undetectable		 2nmyB-1pjmB:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 GLY B 335
ALA B 336
GLY B 303
ALA B 316
ILE B 317
 None
 0.91A 2nmzB-1pjmB:
undetectable		 2nmzB-1pjmB:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 8 PHE B 196
ILE B 189
GLY B 161
GLY B 162
 None
 0.71A 2qx4A-1pjmB:
undetectable
2qx4B-1pjmB:
undetectable		 2qx4A-1pjmB:
21.00
2qx4B-1pjmB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 6 PHE B 196
ILE B 189
GLY B 161
GLY B 162
 None
 0.72A 2qx6A-1pjmB:
undetectable
2qx6B-1pjmB:
undetectable		 2qx6A-1pjmB:
21.00
2qx6B-1pjmB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 6 LEU B 429
ILE B 444
ILE B 370
LEU B 382
 None
 0.84A 2xkwB-1pjmB:
undetectable		 2xkwB-1pjmB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 GLY B 187
GLY B 191
VAL B 200
THR B 232
LEU B 209
 None
 1.00A 3dh0B-1pjmB:
undetectable		 3dh0B-1pjmB:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 ILE B 286
LEU B 246
GLU B 284
PRO B 242
ASN B 241
 None
 1.37A 3eigA-1pjmB:
undetectable		 3eigA-1pjmB:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 GLY B 335
ALA B 336
GLY B 303
ALA B 316
ILE B 317
 None
 0.90A 3ekwB-1pjmB:
undetectable		 3ekwB-1pjmB:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 7 VAL B 379
VAL B 383
LEU B 386
SER B 387
 None
 0.90A 3hs6B-1pjmB:
undetectable		 3hs6B-1pjmB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 6 GLU B 465
ILE B 462
GLU B 458
PHE B 496
 None
 1.11A 3pgyA-1pjmB:
undetectable
3pgyB-1pjmB:
undetectable		 3pgyA-1pjmB:
23.59
3pgyB-1pjmB:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 6 LEU B 256
LEU B 259
LEU B 301
LEU B 268
 None
 1.02A 3q1eA-1pjmB:
undetectable
3q1eC-1pjmB:
undetectable		 3q1eA-1pjmB:
14.95
3q1eC-1pjmB:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 6 LEU B 301
LEU B 268
LEU B 256
LEU B 259
 None
 1.01A 3q1eA-1pjmB:
undetectable
3q1eC-1pjmB:
undetectable		 3q1eA-1pjmB:
14.95
3q1eC-1pjmB:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 7 ILE B 421
VAL B 383
LEU B 386
SER B 387
 None
 0.65A 3r9vA-1pjmB:
0.9
3r9vB-1pjmB:
undetectable		 3r9vA-1pjmB:
19.10
3r9vB-1pjmB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 7 LEU B 343
ILE B 320
VAL B 295
LEU B 298
 None
 0.66A 3r9vA-1pjmB:
0.9
3r9vB-1pjmB:
undetectable		 3r9vA-1pjmB:
19.10
3r9vB-1pjmB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 ASN B 375
HIS B 376
ALA B 364
GLY B 365
ASN B 403
 None
 1.18A 3v3oA-1pjmB:
undetectable		 3v3oA-1pjmB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 11 THR B 232
TRP B 184
ALA B 148
THR B 155
VAL B 159
 None
 1.20A 4e0fA-1pjmB:
undetectable		 4e0fA-1pjmB:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 8 LEU B 210
LEU B 213
LEU B 218
ILE B 252
 None
 0.84A 4klaA-1pjmB:
undetectable		 4klaA-1pjmB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		3 / 3 TRP B 357
GLN B 394
THR B 356
 None
 0.72A 4m2xA-1pjmB:
undetectable		 4m2xA-1pjmB:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 7 ARG B 101
ILE B 115
PHE B 124
THR B  73
 None
 1.03A 4mmcA-1pjmB:
0.0		 4mmcA-1pjmB:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 9 ALA B 148
ASN B 239
GLY B 191
THR B 232
VAL B 200
 None
 1.17A 4r20B-1pjmB:
undetectable		 4r20B-1pjmB:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 11 LEU B 259
LEU B 186
LEU B 212
LEU B 213
LEU B 171
 None
 0.96A 4zowA-1pjmB:
0.0		 4zowA-1pjmB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		3 / 3 ASP B 280
GLU B 354
SER B 194
 None
 0.46A 5bw4B-1pjmB:
undetectable		 5bw4B-1pjmB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		4 / 4 THR B 230
LEU B 226
HIS B 262
GLY B 224
 None
 0.91A 5gwyA-1pjmB:
undetectable		 5gwyA-1pjmB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 ILE B 421
ILE B 422
LEU B 425
ALA B 450
HIS B 418
 None
 1.14A 5km9B-1pjmB:
undetectable		 5km9B-1pjmB:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 ILE B 275
SER B 271
ILE B 317
ALA B 316
VAL B 295
 None
 1.05A 5n0sB-1pjmB:
undetectable		 5n0sB-1pjmB:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 VAL B 339
MET B 359
ALA B 397
VAL B 321
LEU B 314
 None
 1.28A 5tudD-1pjmB:
1.0		 5tudD-1pjmB:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 ALA B 475
LEU B 441
ILE B 444
TYR B 495
PHE B 496
 None
 1.39A 5vlmB-1pjmB:
2.0		 5vlmB-1pjmB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 SER B 488
LEU B 441
ILE B 444
TYR B 495
PHE B 496
 None
 1.35A 5vlmB-1pjmB:
2.0		 5vlmB-1pjmB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 ALA B 475
LEU B 441
ILE B 444
TYR B 495
PHE B 496
 None
 1.28A 5vlmE-1pjmB:
2.1		 5vlmE-1pjmB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 12 ILE B 168
LEU B 209
LEU B 186
ALA B 190
LEU B 236
 None
 0.94A 6ajiA-1pjmB:
0.0		 6ajiA-1pjmB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1pjm IMPORTIN ALPHA-2
SUBUNIT
(Mus
musculus) 		5 / 9 ASN B 239
ILE B 189
GLU B 153
VAL B 159
ILE B 164
 None
 1.25A 6hloA-1pjmB:
undetectable		 6hloA-1pjmB:
21.81