SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pjq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		4 / 8 VAL A 353
SER A 337
ILE A 440
LEU A 355
 None
 0.79A 1igxA-1pjqA:
undetectable		 1igxA-1pjqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		5 / 8 ALA A  28
GLY A  19
GLY A  20
ILE A  46
ALA A  53
 None
ACT  A 504 (-3.3A)
ACT  A 504 (-4.3A)
None
None
 0.94A 1sguA-1pjqA:
undetectable		 1sguA-1pjqA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		4 / 6 SER A 252
ILE A 255
ALA A 223
ALA A 332
 None
None
None
ACT  A 505 (-3.0A)
 0.93A 1w0gA-1pjqA:
undetectable		 1w0gA-1pjqA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		5 / 12 TYR A 339
ALA A 333
SER A 334
ALA A 338
GLY A 302
 None
None
None
None
ACT  A 505 (-3.0A)
 1.08A 2igtA-1pjqA:
6.0		 2igtA-1pjqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		5 / 12 TYR A 339
ALA A 333
SER A 334
ALA A 338
GLY A 302
 None
None
None
None
ACT  A 505 (-3.0A)
 1.08A 2igtB-1pjqA:
5.9		 2igtB-1pjqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		5 / 12 THR A 232
GLY A 302
GLY A 329
LEU A 230
VAL A 251
 None
ACT  A 505 (-3.0A)
None
None
None
 1.15A 3fzgA-1pjqA:
undetectable		 3fzgA-1pjqA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		5 / 6 VAL A  89
SER A 110
LEU A  10
ALA A  76
LEU A  70
 None
 1.49A 3kk6B-1pjqA:
undetectable		 3kk6B-1pjqA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		4 / 6 ILE A 282
ILE A 306
GLY A 308
VAL A 221
 None
ACT  A 505 (-3.6A)
None
None
 0.95A 3n3iA-1pjqA:
undetectable		 3n3iA-1pjqA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		4 / 6 ASN A 201
ARG A 164
TYR A 157
LEU A 188
 None
 1.13A 4f8yA-1pjqA:
3.2
4f8yB-1pjqA:
3.3		 4f8yA-1pjqA:
17.69
4f8yB-1pjqA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		5 / 12 GLY A 421
LEU A 423
PHE A 380
ILE A 440
VAL A 445
 None
 1.14A 4fr0A-1pjqA:
4.6		 4fr0A-1pjqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		3 / 3 ARG A  13
ASP A  14
ARG A  37
 None
 0.44A 4wq4B-1pjqA:
undetectable		 4wq4B-1pjqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		4 / 7 ALA A 332
ARG A 309
GLY A 310
GLU A 312
 ACT  A 505 (-3.0A)
None
None
None
 0.86A 5bs8A-1pjqA:
undetectable
5bs8C-1pjqA:
undetectable
5bs8D-1pjqA:
undetectable		 5bs8A-1pjqA:
21.96
5bs8C-1pjqA:
21.96
5bs8D-1pjqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		4 / 6 ALA A 332
ARG A 309
GLY A 310
GLU A 312
 ACT  A 505 (-3.0A)
None
None
None
 0.94A 5btgA-1pjqA:
0.0
5btgB-1pjqA:
undetectable
5btgC-1pjqA:
0.0		 5btgA-1pjqA:
21.96
5btgB-1pjqA:
21.12
5btgC-1pjqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		4 / 5 GLY A 335
PRO A 436
THR A 412
THR A 331
 None
None
None
ACT  A 505 (-3.4A)
 1.02A 5h5fA-1pjqA:
2.5		 5h5fA-1pjqA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		4 / 5 SER A 252
VAL A 251
GLY A 301
ALA A 223
 None
 1.03A 5k50A-1pjqA:
7.5		 5k50A-1pjqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		3 / 3 VAL A 246
TYR A 247
GLU A 313
 None
 1.00A 5zmqD-1pjqA:
undetectable
5zmqE-1pjqA:
undetectable		 5zmqD-1pjqA:
18.45
5zmqE-1pjqA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		5 / 10 ASP A  14
SER A  72
VAL A  61
GLY A  63
VAL A  18
 None
 1.31A 6hu9L-1pjqA:
0.0
6hu9P-1pjqA:
0.0
6hu9T-1pjqA:
0.0		 6hu9L-1pjqA:
21.30
6hu9P-1pjqA:
16.78
6hu9T-1pjqA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		4 / 7 ALA A 223
GLY A 301
LEU A 250
GLY A 335
 None
 0.76A 6nm4A-1pjqA:
0.0		 6nm4A-1pjqA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1pjq SIROHEME SYNTHASE
(Salmonella
enterica) 		5 / 9 ILE A 255
ALA A 223
GLY A 301
LEU A 250
GLY A 335
 None
 0.93A 6nm4B-1pjqA:
undetectable		 6nm4B-1pjqA:
18.85