SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 1pk1 POLYHOMEOTIC-PROXIMA
L CHROMATIN PROTEIN
(Drosophila
melanogaster) 		5 / 8 PHE A  25
SER A  77
ILE A  78
GLU A  76
LEU A  50
 None
 1.35A 1eupA-1pk1A:
undetectable		 1eupA-1pk1A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_A_ADNA439_1
(ADENOSYLHOMOCYSTEINA
SE)		 1pk1 POLYHOMEOTIC-PROXIMA
L CHROMATIN PROTEIN
SEX COMB ON MIDLEG
CG9495-PA
(Drosophila
melanogaster) 		5 / 10 LEU A  57
HIS A  56
GLN A  42
LEU B  70
GLY B  67
 None
 1.38A 3h9uA-1pk1A:
undetectable		 3h9uA-1pk1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1pk1 POLYHOMEOTIC-PROXIMA
L CHROMATIN PROTEIN
SEX COMB ON MIDLEG
CG9495-PA
(Drosophila
melanogaster) 		5 / 10 LEU A  57
HIS A  56
GLN A  42
LEU B  70
GLY B  67
 None
 1.46A 3h9uC-1pk1A:
undetectable		 3h9uC-1pk1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H9U_D_ADND438_1
(ADENOSYLHOMOCYSTEINA
SE)		 1pk1 POLYHOMEOTIC-PROXIMA
L CHROMATIN PROTEIN
SEX COMB ON MIDLEG
CG9495-PA
(Drosophila
melanogaster) 		5 / 10 LEU A  57
HIS A  56
GLN A  42
LEU B  70
GLY B  67
 None
 1.46A 3h9uD-1pk1A:
undetectable		 3h9uD-1pk1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1pk1 SEX COMB ON MIDLEG
CG9495-PA
(Drosophila
melanogaster) 		5 / 9 PHE B  40
LEU B  53
VAL B  76
LEU B  64
ILE B  72
 None
 1.17A 3tbgD-1pk1B:
undetectable		 3tbgD-1pk1B:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1pk1 SEX COMB ON MIDLEG
CG9495-PA
(Drosophila
melanogaster) 		4 / 8 ILE B  26
ILE B  45
PHE B  40
VAL B  79
 None
 0.88A 3ua5A-1pk1B:
undetectable		 3ua5A-1pk1B:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1pk1 SEX COMB ON MIDLEG
CG9495-PA
(Drosophila
melanogaster) 		4 / 5 ILE B  26
VAL B  22
CYH B  73
HIS B  36
 None
 1.35A 4rzvA-1pk1B:
undetectable		 4rzvA-1pk1B:
12.94