SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pk6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
(Homo
sapiens) 		4 / 6 ILE B 113
TYR B 145
PHE B 215
PHE B 170
 None
 1.27A 1e73M-1pk6B:
undetectable		 1e73M-1pk6B:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 GLY C 201
HIS C 146
LEU C 150
VAL C 193
PHE C 209
 None
 1.13A 1eqbA-1pk6C:
undetectable		 1eqbA-1pk6C:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 GLY C 201
HIS C 146
LEU C 150
VAL C 193
PHE C 209
 None
 1.13A 1eqbB-1pk6C:
undetectable		 1eqbB-1pk6C:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 GLY C 201
HIS C 146
LEU C 150
VAL C 193
PHE C 209
 None
 1.13A 1eqbC-1pk6C:
undetectable		 1eqbC-1pk6C:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 GLY C 201
HIS C 146
LEU C 150
VAL C 193
PHE C 209
 None
 1.13A 1eqbD-1pk6C:
undetectable		 1eqbD-1pk6C:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens) 		4 / 8 VAL C 159
VAL C 161
ILE B 214
LEU C 181
 None
 0.89A 1igxA-1pk6C:
undetectable		 1igxA-1pk6C:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.16A 1q23B-1pk6A:
undetectable		 1q23B-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.13A 1q23C-1pk6A:
undetectable		 1q23C-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 10 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.13A 1q23E-1pk6A:
0.0		 1q23E-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 11 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.08A 1q23F-1pk6A:
undetectable		 1q23F-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.09A 1q23H-1pk6A:
undetectable
1q23I-1pk6A:
undetectable		 1q23H-1pk6A:
18.54
1q23I-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 11 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.12A 1q23I-1pk6A:
0.0		 1q23I-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 10 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.15A 1q23K-1pk6A:
undetectable		 1q23K-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 11 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.08A 1q23L-1pk6A:
undetectable		 1q23L-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		3 / 3 ARG A 163
VAL A 195
TRP A 194
 None
 1.26A 1qw6A-1pk6A:
undetectable		 1qw6A-1pk6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		3 / 3 ARG A 163
VAL A 195
TRP A 194
 None
 1.15A 1qwcA-1pk6A:
undetectable		 1qwcA-1pk6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1URM_A_BEZA201_0
(PEROXIREDOXIN 5)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
(Homo
sapiens;
Homo
sapiens) 		5 / 9 PRO A  93
PRO A 221
GLY A 135
LEU B 220
PHE B 221
 None
 1.50A 1urmA-1pk6A:
undetectable		 1urmA-1pk6A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		3 / 3 ARG A 163
VAL A 195
TRP A 194
 None
 1.23A 1vagA-1pk6A:
undetectable		 1vagA-1pk6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		3 / 3 ARG A 163
VAL A 195
TRP A 194
 None
 1.22A 1zviA-1pk6A:
undetectable		 1zviA-1pk6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
(Homo
sapiens) 		4 / 7 SER B 148
ALA B 147
SER B 213
SER B 149
 None
 1.08A 2i91A-1pk6B:
undetectable		 2i91A-1pk6B:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
(Homo
sapiens) 		4 / 7 SER B 148
ALA B 147
SER B 213
SER B 149
 None
 1.08A 2i91B-1pk6B:
undetectable		 2i91B-1pk6B:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		4 / 5 VAL B 180
SER A 180
VAL A 178
SER C 176
 None
 1.29A 2j9cA-1pk6B:
0.0
2j9cB-1pk6B:
0.0
2j9cC-1pk6B:
0.0		 2j9cA-1pk6B:
19.33
2j9cB-1pk6B:
19.33
2j9cC-1pk6B:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 PHE C 212
LEU C 214
GLN C  91
ALA A  94
PHE A 217
 None
 1.37A 3apwB-1pk6C:
undetectable		 3apwB-1pk6C:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 VAL C 208
PHE B 218
LEU C 180
PHE C 212
TYR A 138
 None
 1.40A 3apxA-1pk6C:
undetectable		 3apxA-1pk6C:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA303_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens;
Homo
sapiens) 		4 / 4 GLN A 177
GLN C 173
GLY C 166
HIS C 167
 CA  B   1 (-3.2A)
CA  B   1 ( 4.7A)
None
None
 1.39A 3huoA-1pk6A:
0.2		 3huoA-1pk6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGL_A_GLYA301_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLY B 184
THR B 144
GLN A 142
THR B 182
 None
 0.91A 3rglA-1pk6B:
undetectable		 3rglA-1pk6B:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.01A 3u9fB-1pk6A:
undetectable
3u9fC-1pk6A:
undetectable		 3u9fB-1pk6A:
18.54
3u9fC-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 10 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.07A 3u9fE-1pk6A:
undetectable		 3u9fE-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.00A 3u9fH-1pk6A:
undetectable
3u9fI-1pk6A:
undetectable		 3u9fH-1pk6A:
18.54
3u9fI-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 10 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.03A 3u9fI-1pk6A:
undetectable		 3u9fI-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.00A 3u9fJ-1pk6A:
undetectable
3u9fK-1pk6A:
undetectable		 3u9fJ-1pk6A:
18.54
3u9fK-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 10 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.03A 3u9fK-1pk6A:
undetectable		 3u9fK-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 11 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 0.99A 3u9fN-1pk6A:
undetectable
3u9fO-1pk6A:
undetectable		 3u9fN-1pk6A:
18.54
3u9fO-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_P_CLMP221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 9 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 0.99A 3u9fP-1pk6A:
0.0		 3u9fP-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 10 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 0.98A 3u9fR-1pk6A:
undetectable		 3u9fR-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 12 SER A 145
LEU A 151
VAL A 195
PHE A 111
VAL A 143
 None
 1.01A 3u9fP-1pk6A:
undetectable
3u9fS-1pk6A:
undetectable		 3u9fP-1pk6A:
18.54
3u9fS-1pk6A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
(Homo
sapiens) 		3 / 3 ASN B 124
PHE B  97
TYR B 141
 None
 0.88A 4u15A-1pk6B:
undetectable		 4u15A-1pk6B:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
(Homo
sapiens) 		3 / 3 ARG A 163
VAL A 195
TRP A 194
 None
 1.15A 5fvoA-1pk6A:
undetectable		 5fvoA-1pk6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 10 GLY B 183
GLY B 184
TYR B 142
PHE B 115
PHE B 215
 None
 1.47A 5lbtA-1pk6B:
undetectable
5lbtB-1pk6B:
undetectable		 5lbtA-1pk6B:
20.08
5lbtB-1pk6B:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens) 		5 / 10 GLY C 177
GLY C 178
TYR C 139
PHE C 112
PHE C 209
 None
 1.49A 5lbtA-1pk6C:
undetectable
5lbtB-1pk6C:
undetectable		 5lbtA-1pk6C:
20.41
5lbtB-1pk6C:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
(Homo
sapiens) 		3 / 3 PHE B 221
ASP B 223
LYS B 188
 None
 0.88A 6awtD-1pk6B:
0.0		 6awtD-1pk6B:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, C
CHAIN PRECURSOR
(Homo
sapiens;
Homo
sapiens) 		4 / 8 GLN A 177
THR A 171
LYS C 170
GLU A 148
 CA  B   1 (-3.2A)
None
None
None
 0.98A 6fbvC-1pk6A:
undetectable		 6fbvC-1pk6A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1pk6 COMPLEMENT C1Q
SUBCOMPONENT, A
CHAIN PRECURSOR
COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR
(Homo
sapiens;
Homo
sapiens) 		4 / 5 GLN A 146
GLU A 209
ASP A 211
ASN B 152
 None
 1.38A 6iftA-1pk6A:
undetectable		 6iftA-1pk6A:
17.47