SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 11 TYR A 129
ALA A 127
PHE A 130
LEU A 116
GLN A 145
 None
 0.95A 1uduA-1pk8A:
undetectable		 1uduA-1pk8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 12 TYR A 129
ALA A 127
PHE A 130
LEU A 116
GLN A 145
 None
 0.94A 1uduB-1pk8A:
undetectable		 1uduB-1pk8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 10 TYR A 129
ALA A 127
PHE A 130
LEU A 116
GLN A 145
 None
 0.97A 1uhoA-1pk8A:
undetectable		 1uhoA-1pk8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 12 MET A 414
LEU A 116
ILE A 406
PHE A 130
ILE A 141
 None
 1.09A 1xotA-1pk8A:
undetectable		 1xotA-1pk8A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 12 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.30A 3u9fB-1pk8A:
undetectable
3u9fC-1pk8A:
undetectable		 3u9fB-1pk8A:
19.66
3u9fC-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 12 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.34A 3u9fB-1pk8A:
undetectable
3u9fC-1pk8A:
undetectable		 3u9fB-1pk8A:
19.66
3u9fC-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 12 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.34A 3u9fH-1pk8A:
undetectable
3u9fI-1pk8A:
undetectable		 3u9fH-1pk8A:
19.66
3u9fI-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_H_CLMH221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 12 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.42A 3u9fH-1pk8A:
undetectable
3u9fI-1pk8A:
undetectable		 3u9fH-1pk8A:
19.66
3u9fI-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 10 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.34A 3u9fI-1pk8A:
undetectable		 3u9fI-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 10 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.36A 3u9fI-1pk8A:
undetectable		 3u9fI-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 12 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.33A 3u9fJ-1pk8A:
undetectable
3u9fK-1pk8A:
undetectable		 3u9fJ-1pk8A:
19.66
3u9fK-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 12 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.38A 3u9fJ-1pk8A:
undetectable
3u9fK-1pk8A:
undetectable		 3u9fJ-1pk8A:
19.66
3u9fK-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 10 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.28A 3u9fK-1pk8A:
undetectable		 3u9fK-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 10 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.38A 3u9fK-1pk8A:
undetectable		 3u9fK-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_M_CLMM221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 10 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.35A 3u9fM-1pk8A:
0.0
3u9fN-1pk8A:
0.0		 3u9fM-1pk8A:
19.66
3u9fN-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 11 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.37A 3u9fN-1pk8A:
undetectable
3u9fO-1pk8A:
undetectable		 3u9fN-1pk8A:
19.66
3u9fO-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 11 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.38A 3u9fN-1pk8A:
undetectable
3u9fO-1pk8A:
undetectable		 3u9fN-1pk8A:
19.66
3u9fO-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 12 SER A 390
SER A 212
LEU A 116
VAL A 143
VAL A 410
 None
 1.35A 3u9fP-1pk8A:
undetectable
3u9fS-1pk8A:
undetectable		 3u9fP-1pk8A:
19.66
3u9fS-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 12 SER A 390
SER A 212
VAL A 143
PHE A 130
VAL A 410
 None
 1.38A 3u9fP-1pk8A:
undetectable
3u9fS-1pk8A:
undetectable		 3u9fP-1pk8A:
19.66
3u9fS-1pk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		4 / 5 ALA A 127
ILE A 141
LEU A 116
LYS A 142
 None
 1.20A 4g19A-1pk8A:
undetectable		 4g19A-1pk8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		3 / 3 ASN A 322
ASP A 402
ASP A 397
 None
 0.63A 4obwD-1pk8A:
undetectable		 4obwD-1pk8A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		4 / 4 LEU A 405
ARG A 186
ILE A 406
ILE A 369
 None
 1.39A 5dzk2-1pk8A:
undetectable
5dzkM-1pk8A:
undetectable
5dzkN-1pk8A:
undetectable		 5dzk2-1pk8A:
1.69
5dzkM-1pk8A:
19.01
5dzkN-1pk8A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 11 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
 1.15A 5lg3A-1pk8A:
0.0		 5lg3A-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_B_Z80B401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 9 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
 1.16A 5lg3B-1pk8A:
0.0		 5lg3B-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_C_Z80C401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 9 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
 1.15A 5lg3C-1pk8A:
0.0		 5lg3C-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_D_Z80D401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 9 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
 1.16A 5lg3D-1pk8A:
0.0		 5lg3D-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 10 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
 1.19A 5lg3F-1pk8A:
undetectable		 5lg3F-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 10 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
 1.14A 5lg3G-1pk8A:
0.0		 5lg3G-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		5 / 10 ILE A 308
VAL A 267
GLU A 373
ASP A 313
ILE A 385
 ATP  A 800 (-4.1A)
ATP  A 800 (-4.3A)
CA  A 817 ( 2.2A)
ATP  A 800 (-3.6A)
ATP  A 800 ( 4.5A)
 1.17A 5lg3H-1pk8A:
0.0		 5lg3H-1pk8A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		3 / 3 LYS A 238
LEU A 235
ARG A 234
 None
 0.95A 5yw0A-1pk8A:
undetectable		 5yw0A-1pk8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1pk8 RAT SYNAPSIN I
(Rattus
norvegicus) 		3 / 3 GLY A 132
ASP A 140
ILE A 135
 None
 0.53A 6dgxB-1pk8A:
undetectable		 6dgxB-1pk8A:
10.10