SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		5 / 8 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.16A 1cmaA-1pkoA:
undetectable
1cmaB-1pkoA:
undetectable		 1cmaA-1pkoA:
23.57
1cmaB-1pkoA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		5 / 10 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.21A 1cmcA-1pkoA:
undetectable
1cmcB-1pkoA:
undetectable		 1cmcA-1pkoA:
23.57
1cmcB-1pkoA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		4 / 8 VAL A 115
ARG A  68
ALA A  20
GLU A  93
 None
 1.04A 1dmiA-1pkoA:
0.0
1dmiB-1pkoA:
0.0		 1dmiA-1pkoA:
16.71
1dmiB-1pkoA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		5 / 9 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.18A 1mj2A-1pkoA:
undetectable		 1mj2A-1pkoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		5 / 9 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.18A 1mj2C-1pkoA:
undetectable		 1mj2C-1pkoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		5 / 12 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.22A 1mj2C-1pkoA:
undetectable
1mj2D-1pkoA:
undetectable		 1mj2C-1pkoA:
23.40
1mj2D-1pkoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		5 / 11 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.12A 1mjlA-1pkoA:
undetectable
1mjlB-1pkoA:
undetectable		 1mjlA-1pkoA:
23.40
1mjlB-1pkoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		5 / 9 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.19A 1mjoA-1pkoA:
undetectable		 1mjoA-1pkoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		5 / 9 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.18A 1mjoB-1pkoA:
undetectable		 1mjoB-1pkoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		5 / 12 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.21A 1mjoC-1pkoA:
undetectable
1mjoD-1pkoA:
undetectable		 1mjoC-1pkoA:
23.40
1mjoD-1pkoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 1pko MYELIN
OLIGODENDROCYTE
GLYCOPROTEIN
(Rattus
norvegicus) 		5 / 9 GLU A  36
ARG A 101
ARG A  52
LEU A  50
GLU A  60
 None
 1.20A 1mjoC-1pkoA:
undetectable		 1mjoC-1pkoA:
23.40