SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		6 / 8 ASP A  55
ASP A  57
TRP A  62
TYR A  64
ARG A  71
TYR A  72
 CL  A  91 ( 4.7A)
None
None
None
CL  A  90 (-3.6A)
None
 0.59A 1ceaA-1pkrA:
18.1
1ceaB-1pkrA:
18.2		 1ceaA-1pkrA:
98.78
1ceaB-1pkrA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		5 / 7 ARG A  34
ASP A  55
TRP A  62
TYR A  64
TYR A  72
 None
CL  A  91 ( 4.7A)
None
None
None
 0.99A 1ceaB-1pkrA:
18.2		 1ceaB-1pkrA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		6 / 7 ASP A  55
ASP A  57
TRP A  62
TYR A  64
ARG A  71
TYR A  72
 CL  A  91 ( 4.7A)
None
None
None
CL  A  90 (-3.6A)
None
 0.54A 1ceaB-1pkrA:
18.2		 1ceaB-1pkrA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		6 / 7 ARG A  34
ASP A  55
TRP A  62
TYR A  64
ARG A  71
TYR A  72
 None
CL  A  91 ( 4.7A)
None
None
CL  A  90 (-3.6A)
None
 0.81A 1cebA-1pkrA:
18.0		 1cebA-1pkrA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		6 / 7 ASP A  55
ASP A  57
TRP A  62
TYR A  64
ARG A  71
TYR A  72
 CL  A  91 ( 4.7A)
None
None
None
CL  A  90 (-3.6A)
None
 0.63A 1cebA-1pkrA:
18.0		 1cebA-1pkrA:
98.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		6 / 7 ASP A  55
ASP A  57
TRP A  62
TYR A  64
ARG A  71
TYR A  72
 CL  A  91 ( 4.7A)
None
None
None
CL  A  90 (-3.6A)
None
 0.61A 1cebB-1pkrA:
17.7		 1cebB-1pkrA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1pkr PLASMINOGEN
(Homo
sapiens) 		3 / 3 GLN A  23
HIS A  31
PRO A  68
 None
 0.88A 1d8cA-1pkrA:
undetectable		 1d8cA-1pkrA:
7.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 1pkr PLASMINOGEN
(Homo
sapiens) 		4 / 7 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 CL  A  91 ( 4.7A)
None
None
CL  A  90 (-3.6A)
 0.56A 2pk4A-1pkrA:
16.0		 2pk4A-1pkrA:
51.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R6V_A_NCAA174_0
(UNCHARACTERIZED
PROTEIN PH0856)		 1pkr PLASMINOGEN
(Homo
sapiens) 		4 / 6 TYR A  74
ASP A  57
TRP A  62
ARG A  34
 None
 1.37A 2r6vA-1pkrA:
undetectable		 2r6vA-1pkrA:
15.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		4 / 7 ASP A  55
ASP A  57
TRP A  62
ARG A  71
 CL  A  91 ( 4.7A)
None
None
CL  A  90 (-3.6A)
 0.52A 3kivA-1pkrA:
16.1		 3kivA-1pkrA:
55.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		4 / 7 TYR A  74
ASP A  57
TRP A  62
ARG A  34
 None
 1.39A 3zodA-1pkrA:
undetectable		 3zodA-1pkrA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB5_A_NMYA301_0
(AAC(3)-IIIB PROTEIN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		5 / 11 TYR A   9
ASP A  73
THR A  16
GLY A  60
ASP A  57
 None
 1.41A 6mb5A-1pkrA:
undetectable		 6mb5A-1pkrA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_A_NMYA303_0
(AAC(3)-IIIB PROTEIN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		5 / 10 TYR A   9
ASP A  73
THR A  16
GLY A  60
ASP A  57
 None
 1.44A 6mb9A-1pkrA:
undetectable		 6mb9A-1pkrA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 1pkr PLASMINOGEN
(Homo
sapiens) 		5 / 10 TYR A   9
ASP A  73
THR A  16
GLY A  60
ASP A  57
 None
 1.45A 6mb9D-1pkrA:
undetectable		 6mb9D-1pkrA:
18.29