SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pl0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 GLY A  35
ALA A  40
LEU A  41
LEU A  54
VAL A  72
 XMP  A 901 ( 4.3A)
None
None
None
None
 1.16A 1i9gA-1pl0A:
2.4		 1i9gA-1pl0A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 5 SER A 554
ASN A 463
ALA A 462
ASP A 460
 None
 1.13A 1lqtA-1pl0A:
undetectable
1lqtB-1pl0A:
3.1		 1lqtA-1pl0A:
23.86
1lqtB-1pl0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 5 SER A 554
ASN A 463
ALA A 462
ASP A 460
 None
 1.14A 1lquA-1pl0A:
3.1
1lquB-1pl0A:
2.2		 1lquA-1pl0A:
23.86
1lquB-1pl0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 10 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
 None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
 1.11A 1pxxA-1pl0A:
undetectable		 1pxxA-1pl0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
 None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
 1.10A 1pxxC-1pl0A:
undetectable		 1pxxC-1pl0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q97_B_ADNB486_1
(SR PROTEIN KINASE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 4 VAL A  48
ALA A  33
LEU A  17
PHE A   9
 None
 0.64A 1q97B-1pl0A:
undetectable		 1q97B-1pl0A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 ALA A 262
ALA A 263
ASN A 245
LEU A 249
ALA A 261
 None
 0.97A 2aclA-1pl0A:
undetectable
2aclE-1pl0A:
undetectable		 2aclA-1pl0A:
18.46
2aclE-1pl0A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 11 ALA A 262
ALA A 263
ASN A 245
LEU A 249
ALA A 261
 None
 1.04A 2aclE-1pl0A:
undetectable		 2aclE-1pl0A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		3 / 3 ARG A 335
ASP A 326
ASP A 323
 None
 0.86A 2ejtA-1pl0A:
2.7		 2ejtA-1pl0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 ILE A 444
ALA A 551
GLY A 459
GLY A 443
ARG A 545
 None
 1.17A 2okcB-1pl0A:
undetectable		 2okcB-1pl0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 9 ALA A 421
ALA A 309
GLY A 272
GLY A 443
ILE A 442
 None
 1.36A 2v7bA-1pl0A:
3.5		 2v7bA-1pl0A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 8 TYR A 104
SER A  12
SER A  10
LYS A  14
 XMP  A 901 (-4.1A)
XMP  A 901 (-2.6A)
XMP  A 901 (-3.0A)
XMP  A 901 (-3.4A)
 1.34A 2vmyA-1pl0A:
undetectable
2vmyB-1pl0A:
undetectable		 2vmyA-1pl0A:
21.42
2vmyB-1pl0A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 7 GLU A 501
LEU A 505
MET A 312
TYR A 464
 None
 1.03A 2w8yA-1pl0A:
undetectable		 2w8yA-1pl0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 9 ALA A 273
VAL A 441
GLY A 439
LEU A 249
ALA A 424
 None
 0.94A 2z0yB-1pl0A:
undetectable		 2z0yB-1pl0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 ALA A 100
PRO A 148
THR A 156
LEU A  17
VAL A  18
 None
 1.19A 2zifA-1pl0A:
undetectable		 2zifA-1pl0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 5 SER A  34
LEU A 103
GLY A 127
CYH A 101
 XMP  A 901 (-2.6A)
None
XMP  A 901 (-3.4A)
XMP  A 901 (-3.5A)
 1.18A 3aiaA-1pl0A:
undetectable
3aiaB-1pl0A:
undetectable		 3aiaA-1pl0A:
15.89
3aiaB-1pl0A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		3 / 3 PRO A 227
LEU A 226
ARG A 194
 None
 0.87A 3aqiA-1pl0A:
undetectable		 3aqiA-1pl0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 8 HIS A 584
ASP A 568
PHE A 542
GLY A 564
 None
 0.87A 3c0zB-1pl0A:
3.1		 3c0zB-1pl0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 ILE A  76
GLY A  75
VAL A  72
ALA A  78
VAL A 142
 None
 0.96A 3fpjA-1pl0A:
2.2		 3fpjA-1pl0A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		3 / 3 GLN A 184
THR A 180
LEU A 384
 None
 0.75A 3ondA-1pl0A:
2.5		 3ondA-1pl0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		3 / 3 GLN A 184
THR A 180
LEU A 384
 None
 0.75A 3ondB-1pl0A:
undetectable		 3ondB-1pl0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 6 ILE A 228
PHE A 318
ALA A 243
ASN A 239
 None
 1.01A 3pgyA-1pl0A:
undetectable
3pgyB-1pl0A:
undetectable		 3pgyA-1pl0A:
22.31
3pgyB-1pl0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 LEU A 321
CYH A 325
ILE A 332
SER A 300
ASP A 317
 None
 1.27A 3vw1D-1pl0A:
undetectable		 3vw1D-1pl0A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 TYR A 104
LEU A 132
VAL A  99
LEU A   8
VAL A  72
 XMP  A 901 (-4.1A)
None
None
None
None
 1.16A 3w68A-1pl0A:
1.1		 3w68A-1pl0A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 7 ASN A 463
GLY A 459
ILE A 536
PHE A 542
 None
 0.84A 4fglC-1pl0A:
undetectable		 4fglC-1pl0A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
 None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
 1.01A 4otyA-1pl0A:
undetectable		 4otyA-1pl0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
 None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
 1.02A 4otyB-1pl0A:
undetectable		 4otyB-1pl0A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
 None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
 1.03A 4rrwD-1pl0A:
undetectable		 4rrwD-1pl0A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
 None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
 1.03A 4rrzD-1pl0A:
undetectable		 4rrzD-1pl0A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 9 ARG A  22
ALA A  21
GLY A  16
LEU A  17
LEU A  41
 None
 0.77A 5dqfA-1pl0A:
undetectable		 5dqfA-1pl0A:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 6 ARG A 307
GLY A 340
ASP A 339
LYS A 357
 None
 1.18A 5hp1C-1pl0A:
0.0		 5hp1C-1pl0A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
 None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
 1.01A 5ikqA-1pl0A:
undetectable		 5ikqA-1pl0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_B_JMSB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		5 / 12 VAL A  99
LEU A   8
LEU A  68
GLY A 127
LEU A 132
 None
None
XMP  A 901 (-4.1A)
XMP  A 901 (-3.4A)
None
 0.98A 5ikqB-1pl0A:
undetectable		 5ikqB-1pl0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		3 / 3 GLY A 316
ASP A 339
ASN A 361
 None
 0.54A 5jglA-1pl0A:
2.5		 5jglA-1pl0A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 6 ARG A 588
PHE A 542
ILE A 452
THR A 455
 None
 1.06A 5vceA-1pl0A:
undetectable		 5vceA-1pl0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 4 HIS A  73
VAL A  99
LEU A 131
ALA A 134
 None
 1.43A 6d8pB-1pl0A:
4.2		 6d8pB-1pl0A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens) 		4 / 6 ILE A 341
TYR A 362
VAL A 319
ARG A 307
 None
 0.96A 6f6jA-1pl0A:
undetectable		 6f6jA-1pl0A:
undetectable