SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ILE A 223
ALA A 258
GLY A 259
ALA A 232
ILE A 231
 NAD  A 400 ( 4.0A)
None
None
None
None
 0.89A 1bx4A-1pl8A:
4.9		 1bx4A-1pl8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLY A 167
VAL A 177
GLY A 160
ILE A 161
VAL A 175
 None
 0.97A 1k6cB-1pl8A:
undetectable		 1k6cB-1pl8A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_ACTC2294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 TRP A 303
TYR A 140
ASN A 301
TYR A 110
 None
 1.48A 1kiaC-1pl8A:
6.9		 1kiaC-1pl8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 TRP A 303
TYR A 140
ASN A 301
TYR A 110
 None
 1.49A 1kiaD-1pl8A:
0.0		 1kiaD-1pl8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 10 GLU A 150
LEU A 310
LEU A 142
PRO A 143
ALA A  92
 None
 1.42A 1mjqC-1pl8A:
undetectable
1mjqD-1pl8A:
undetectable		 1mjqC-1pl8A:
14.53
1mjqD-1pl8A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 TRP A 303
TYR A 140
ASN A 301
TYR A 110
 None
 1.48A 1nbhB-1pl8A:
0.0		 1nbhB-1pl8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 TRP A 303
TYR A 140
ASN A 301
TYR A 110
 None
 1.47A 1nbhD-1pl8A:
6.5		 1nbhD-1pl8A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 7 GLY A  54
ILE A  60
VAL A  61
PRO A 122
 None
 1.03A 1rxcD-1pl8A:
2.4		 1rxcD-1pl8A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 PHE A 148
SER A  40
GLY A  73
THR A  74
 None
 1.14A 2f7fA-1pl8A:
3.0		 2f7fA-1pl8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ARG A 130
GLN A 354
PRO A 351
 None
 0.90A 2qhfA-1pl8A:
0.0		 2qhfA-1pl8A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 GLY A 181
ASP A 203
SER A 205
 NAD  A 400 (-3.2A)
NAD  A 400 (-2.6A)
None
 0.63A 3brfA-1pl8A:
undetectable		 3brfA-1pl8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 4 VAL A 175
ARG A 166
ILE A 183
THR A 263
 None
None
NAD  A 400 (-3.8A)
None
 0.97A 3cl9A-1pl8A:
2.4		 3cl9A-1pl8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 8 LEU A 204
GLY A 179
GLY A 259
ILE A 256
ILE A 223
 NAD  A 400 (-4.0A)
NAD  A 400 ( 3.9A)
None
None
NAD  A 400 ( 4.0A)
 1.12A 3ekpA-1pl8A:
undetectable		 3ekpA-1pl8A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 VAL A 190
ILE A 183
VAL A 272
VAL A 296
 None
NAD  A 400 (-3.8A)
NAD  A 400 (-4.5A)
NAD  A 400 (-4.7A)
 0.76A 3fi0G-1pl8A:
2.6		 3fi0G-1pl8A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ILE A 161
GLY A 160
PRO A 156
ALA A 191
VAL A 190
 None
 0.75A 3jb2A-1pl8A:
3.4		 3jb2A-1pl8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ILE A 161
GLY A 160
PRO A 156
ALA A 191
VAL A 190
 None
 0.73A 3jb3A-1pl8A:
0.0		 3jb3A-1pl8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 ALA A 152
SER A  72
ASN A   8
LEU A 128
GLY A  68
 None
 1.23A 3nrrA-1pl8A:
2.4		 3nrrA-1pl8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		6 / 12 ALA A 191
GLY A 216
ILE A 215
LEU A 209
ARG A 208
VAL A 201
 None
None
None
None
NAD  A 400 (-3.1A)
None
 1.45A 3o7wA-1pl8A:
4.2		 3o7wA-1pl8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 ILE A 307
VAL A  91
LEU A  36
CYH A 139
 None
 0.81A 4asdA-1pl8A:
undetectable		 4asdA-1pl8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 LEU A 209
ALA A 212
ILE A 183
SER A 205
GLY A 160
 None
None
NAD  A 400 (-3.8A)
None
None
 1.08A 4dm8B-1pl8A:
undetectable		 4dm8B-1pl8A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 8 GLY A  54
ILE A  60
VAL A  61
PRO A 122
 None
 1.00A 4e1vG-1pl8A:
undetectable		 4e1vG-1pl8A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 9 ALA A 252
ILE A 293
GLY A 259
ALA A 258
VAL A 281
 NAD  A 400 ( 3.8A)
None
None
None
None
 1.00A 4r1zA-1pl8A:
undetectable		 4r1zA-1pl8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 4 VAL A  41
GLU A  70
GLY A  68
LEU A 128
 None
ZN  A 402 (-3.2A)
None
None
 1.20A 5g5gC-1pl8A:
undetectable		 5g5gC-1pl8A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		3 / 3 ILE A  93
ILE A 154
MET A  38
 None
 0.70A 5i9yA-1pl8A:
undetectable		 5i9yA-1pl8A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		6 / 12 THR A 246
ILE A 223
ALA A 258
GLY A 259
ALA A 232
ILE A 231
 None
NAD  A 400 ( 4.0A)
None
None
None
None
 1.22A 5kb6A-1pl8A:
5.9		 5kb6A-1pl8A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		6 / 12 THR A 246
VAL A 200
ILE A 223
ALA A 258
GLY A 259
ILE A 231
 None
None
NAD  A 400 ( 4.0A)
None
None
None
 1.19A 5kb6A-1pl8A:
5.9		 5kb6A-1pl8A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		6 / 12 THR A 246
ILE A 223
ALA A 258
GLY A 259
ALA A 232
ILE A 231
 None
NAD  A 400 ( 4.0A)
None
None
None
None
 1.22A 5kb6B-1pl8A:
4.5		 5kb6B-1pl8A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		6 / 12 THR A 246
VAL A 200
ILE A 223
ALA A 258
GLY A 259
ILE A 231
 None
None
NAD  A 400 ( 4.0A)
None
None
None
 1.19A 5kb6B-1pl8A:
4.5		 5kb6B-1pl8A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 6 TYR A  50
PHE A  59
THR A 121
GLY A  54
 None
 1.27A 5mraA-1pl8A:
0.0
5mraB-1pl8A:
undetectable		 5mraA-1pl8A:
17.03
5mraB-1pl8A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 4 HIS A  84
VAL A  34
LEU A  85
ALA A 137
 None
 1.08A 6d8pB-1pl8A:
3.6		 6d8pB-1pl8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		4 / 4 HIS A  84
VAL A  75
LEU A  85
ALA A 136
 None
 1.35A 6d8pB-1pl8A:
3.6		 6d8pB-1pl8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLY A 181
ALA A 180
VAL A 220
VAL A 199
VAL A 201
 NAD  A 400 (-3.2A)
NAD  A 400 ( 4.9A)
None
None
None
 0.89A 6dh0A-1pl8A:
undetectable		 6dh0A-1pl8A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 1pl8 HUMAN SORBITOL
DEHYDROGENASE
(Homo
sapiens) 		5 / 12 GLY A 195
ALA A 196
GLY A 168
VAL A 177
VAL A 199
 None
 1.02A 6dh0B-1pl8A:
undetectable		 6dh0B-1pl8A:
14.34