SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pmi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		3 / 3 GLN A 111
HIS A 285
PRO A 284
 ZN  A 445 (-3.2A)
ZN  A 445 (-3.3A)
None
 0.79A 1d8cA-1pmiA:
undetectable		 1d8cA-1pmiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		5 / 12 ILE A 110
GLY A 258
CYH A 261
LEU A 158
LEU A 168
 None
 1.37A 1fm6X-1pmiA:
undetectable		 1fm6X-1pmiA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		4 / 8 SER A   2
SER A  59
ALA A  61
ILE A   9
 None
 0.99A 1gm7A-1pmiA:
undetectable
1gm7B-1pmiA:
undetectable		 1gm7A-1pmiA:
20.54
1gm7B-1pmiA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		4 / 7 ASP A 291
ALA A  26
GLY A  22
ILE A  21
 None
 0.84A 1t7iB-1pmiA:
undetectable		 1t7iB-1pmiA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		4 / 7 ALA A 163
ILE A 181
ILE A 184
ASP A 156
 None
 0.85A 1upfB-1pmiA:
undetectable		 1upfB-1pmiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		4 / 7 ASP A 291
ALA A  26
GLY A  22
ILE A  21
 None
 0.78A 2fxdB-1pmiA:
undetectable		 2fxdB-1pmiA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		3 / 3 LEU A  95
PRO A  96
ARG A 436
 None
 0.59A 2qd4B-1pmiA:
undetectable		 2qd4B-1pmiA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		3 / 3 LEU A  95
PRO A  96
ARG A 436
 None
 0.54A 2qd5A-1pmiA:
undetectable		 2qd5A-1pmiA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		4 / 8 ILE A 288
PHE A 307
LEU A 249
GLY A 262
 None
 0.83A 2vdbA-1pmiA:
0.0		 2vdbA-1pmiA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		5 / 12 ILE A  85
GLY A 380
LEU A  69
LEU A  72
VAL A  73
 None
 1.15A 3adsB-1pmiA:
0.0		 3adsB-1pmiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		4 / 7 ASP A 291
SER A  23
GLU A  42
ASP A  41
 None
 1.23A 3bc9A-1pmiA:
undetectable		 3bc9A-1pmiA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		4 / 8 TYR A  13
LEU A  49
GLY A  19
ILE A  40
 None
 0.81A 3jusB-1pmiA:
undetectable		 3jusB-1pmiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		3 / 3 LEU A  95
PRO A  96
ARG A 436
 None
 0.68A 4klrB-1pmiA:
undetectable		 4klrB-1pmiA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		4 / 8 MET A 210
PHE A 206
LEU A 321
PHE A 146
 None
 0.89A 4rkuA-1pmiA:
undetectable
4rkuJ-1pmiA:
0.0		 4rkuA-1pmiA:
21.44
4rkuJ-1pmiA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		4 / 6 PRO A  96
PHE A 412
THR A  53
ARG A 436
 None
 1.11A 4xe5A-1pmiA:
undetectable		 4xe5A-1pmiA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		5 / 12 LEU A 279
ASN A 272
LEU A 245
PHE A 149
ILE A 288
 None
 1.43A 5dv4A-1pmiA:
undetectable		 5dv4A-1pmiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		5 / 12 GLU A 319
LEU A 321
GLY A 207
MET A 210
ALA A 305
 None
 0.91A 5kc4A-1pmiA:
undetectable		 5kc4A-1pmiA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pmi PHOSPHOMANNOSE
ISOMERASE
(Candida
albicans) 		5 / 12 LEU A 317
GLY A 262
ILE A 257
MET A 210
LEU A 242
 None
 0.96A 5ycnA-1pmiA:
undetectable		 5ycnA-1pmiA:
20.09