SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		6 / 8 ASP A  55
ASP A  57
TRP A  62
HIS A  64
LEU A  70
TRP A  72
 None
None
None
CL  A 289 (-4.8A)
None
None
 0.87A 1pk2A-1pmlA:
12.7		 1pk2A-1pmlA:
95.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 8 TYR A  35
ASP A  57
TRP A  62
HIS A  64
 CL  A 289 (-4.8A)
None
None
CL  A 289 (-4.8A)
 0.77A 1pk2A-1pmlA:
12.7		 1pk2A-1pmlA:
95.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 7 ASP A  55
ASP A  57
TRP A  62
TRP A  72
 None
 0.39A 2pk4A-1pmlA:
13.1		 2pk4A-1pmlA:
44.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		3 / 3 GLU A  73
GLU A  17
TRP A  72
 None
 1.10A 3hrdA-1pmlA:
undetectable
3hrdE-1pmlA:
undetectable
3hrdF-1pmlA:
undetectable		 3hrdA-1pmlA:
11.56
3hrdE-1pmlA:
11.56
3hrdF-1pmlA:
15.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 7 ASP A  55
ASP A  57
TRP A  62
TRP A  72
 None
 0.29A 3kivA-1pmlA:
13.4		 3kivA-1pmlA:
42.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 5 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.49A 4olaA-1pmlA:
undetectable		 4olaA-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 5 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.31A 4olbA-1pmlA:
undetectable		 4olbA-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 4 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.49A 4w5oA-1pmlA:
undetectable		 4w5oA-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 4 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.47A 4w5rA-1pmlA:
undetectable		 4w5rA-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 5 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.49A 4w5tA-1pmlA:
undetectable		 4w5tA-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 5 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.44A 4z4dA-1pmlA:
undetectable		 4z4dA-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 4 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.45A 4z4eA-1pmlA:
undetectable		 4z4eA-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 5 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.45A 5js1A-1pmlA:
undetectable		 5js1A-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2
(Homo
sapiens) 		4 / 5 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.37A 6cbdA-1pmlA:
undetectable		 6cbdA-1pmlA:
7.13