SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
PRO A  38
THR A  53
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.80A 1cbrA-1pmpA:
19.4		 1cbrA-1pmpA:
40.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
PRO A  38
THR A  53
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.80A 1cbrB-1pmpA:
19.4		 1cbrB-1pmpA:
40.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
PRO A  38
THR A  53
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.76A 1cbsA-1pmpA:
19.2		 1cbsA-1pmpA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
PRO A  38
THR A  53
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.80A 2fr3A-1pmpA:
19.3		 2fr3A-1pmpA:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		10 / 12 PHE A  16
VAL A  25
SER A  55
THR A  60
ALA A  75
ASP A  76
ARG A  78
CYH A 117
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
OLA  A 200 ( 4.3A)
None
OLA  A 200 ( 4.0A)
OLA  A 200 ( 4.7A)
None
OLA  A 200 ( 4.4A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.54A 2qm9A-1pmpA:
24.5		 2qm9A-1pmpA:
63.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_A_TDZA201_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 4 TYR A  19
MET A  20
PRO A  38
ILE A 104
 None
OLA  A 200 (-4.6A)
None
None
 0.64A 2qm9A-1pmpA:
24.5		 2qm9A-1pmpA:
63.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		11 / 12 PHE A  16
TYR A  19
VAL A  25
SER A  55
THR A  60
ALA A  75
ARG A  78
ILE A 104
CYH A 117
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
None
None
OLA  A 200 ( 4.3A)
None
OLA  A 200 ( 4.0A)
None
None
OLA  A 200 ( 4.4A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.56A 2qm9B-1pmpA:
25.1		 2qm9B-1pmpA:
63.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 4 MET A  20
PRO A  38
ASP A  76
ARG A 106
 OLA  A 200 (-4.6A)
None
OLA  A 200 ( 4.7A)
OLA  A 200 (-3.2A)
 0.79A 2qm9B-1pmpA:
25.1		 2qm9B-1pmpA:
63.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 8 GLU A  72
SER A  82
GLN A  93
CYH A 117
 None
None
None
OLA  A 200 ( 4.4A)
 1.17A 3b9lA-1pmpA:
undetectable		 3b9lA-1pmpA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 7 PHE A   4
LEU A  91
LEU A  66
LEU A  86
 None
 0.66A 3bgdB-1pmpA:
undetectable		 3bgdB-1pmpA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		3 / 3 ARG A  30
THR A  60
THR A 102
 None
 0.69A 3k2hB-1pmpA:
undetectable		 3k2hB-1pmpA:
14.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		12 / 12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
ARG A  78
ILE A 104
ARG A 106
VAL A 115
CYH A 117
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
OLA  A 200 (-4.6A)
None
None
OLA  A 200 ( 4.7A)
None
None
OLA  A 200 (-3.2A)
None
OLA  A 200 ( 4.4A)
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.70A 3p6gA-1pmpA:
24.3		 3p6gA-1pmpA:
65.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		8 / 12 PHE A  16
MET A  20
VAL A  25
PRO A  38
ASP A  76
CYH A 124
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
OLA  A 200 (-4.6A)
None
None
OLA  A 200 ( 4.7A)
None
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 1.23A 3p6gA-1pmpA:
24.3		 3p6gA-1pmpA:
65.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		7 / 7 PHE A  16
MET A  20
ASP A  76
ILE A 104
VAL A 115
ARG A 126
TYR A 128
 OLA  A 200 ( 4.8A)
OLA  A 200 (-4.6A)
OLA  A 200 ( 4.7A)
None
None
OLA  A 200 (-3.9A)
OLA  A 200 (-4.7A)
 0.59A 3p6hA-1pmpA:
24.3		 3p6hA-1pmpA:
65.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 8 GLN A  95
PHE A  70
THR A  53
THR A  60
 None
None
OLA  A 200 ( 4.7A)
None
 0.86A 4n16A-1pmpA:
undetectable		 4n16A-1pmpA:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 6 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.72A 4qztA-1pmpA:
20.3		 4qztA-1pmpA:
34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 6 TYR A  19
GLU A  72
THR A  74
GLN A  95
 None
 0.72A 4qzuC-1pmpA:
20.5		 4qzuC-1pmpA:
34.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
TYR A  19
VAL A  25
ILE A  51
SER A  55
 OLA  A 200 ( 4.8A)
None
None
None
OLA  A 200 ( 4.3A)
 0.71A 5hbsA-1pmpA:
19.9		 5hbsA-1pmpA:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		5 / 12 PHE A  16
VAL A  25
PRO A  38
ILE A  51
SER A  55
 OLA  A 200 ( 4.8A)
None
None
None
OLA  A 200 ( 4.3A)
 0.77A 5hbsA-1pmpA:
19.9		 5hbsA-1pmpA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 1pmp P2 MYELIN PROTEIN
(Bos
taurus) 		4 / 7 GLN A  95
PHE A  70
THR A  53
THR A  60
 None
None
OLA  A 200 ( 4.7A)
None
 0.90A 5m78A-1pmpA:
undetectable		 5m78A-1pmpA:
20.83