SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		3 / 3 VAL A 108
ALA A 107
HIS A 156
 None
 0.61A 1q23C-1pn3A:
undetectable		 1q23C-1pn3A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		3 / 3 VAL A 108
ALA A 107
HIS A 156
 None
 0.51A 1q23H-1pn3A:
undetectable		 1q23H-1pn3A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		3 / 3 VAL A 108
ALA A 107
HIS A 156
 None
 0.53A 1q23G-1pn3A:
undetectable		 1q23G-1pn3A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		3 / 3 VAL A 108
ALA A 107
HIS A 156
 None
 0.76A 1q23L-1pn3A:
undetectable		 1q23L-1pn3A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		3 / 3 VAL A 108
ALA A 107
HIS A 156
 None
 0.47A 1q23J-1pn3A:
0.0		 1q23J-1pn3A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		3 / 3 ARG A 157
VAL A  86
GLY A   7
 None
 0.61A 2avvE-1pn3A:
undetectable		 2avvE-1pn3A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		5 / 12 VAL A 224
SER A 347
VAL A 336
GLY A 335
ALA A 355
 None
 1.29A 2x2iC-1pn3A:
undetectable		 2x2iC-1pn3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 8 THR A 195
ASP A 192
SER A 131
TYR A 173
 None
 1.42A 2xz5A-1pn3A:
0.0
2xz5C-1pn3A:
0.0		 2xz5A-1pn3A:
21.61
2xz5C-1pn3A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 8 THR A 195
GLN A 197
ASP A 192
TYR A 121
 None
 1.10A 2xz5C-1pn3A:
undetectable
2xz5D-1pn3A:
undetectable		 2xz5C-1pn3A:
21.61
2xz5D-1pn3A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 5 ALA A 112
GLY A  92
CYH A  93
LYS A   1
 None
 1.43A 2ylgA-1pn3A:
undetectable		 2ylgA-1pn3A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 7 PHE A 216
GLY A 220
ASP A 271
ARG A 248
 None
 1.14A 3aruA-1pn3A:
undetectable		 3aruA-1pn3A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 4 LEU A 101
ASP A  84
VAL A 108
THR A   6
 None
 1.27A 3cyxB-1pn3A:
undetectable		 3cyxB-1pn3A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 6 TYR A 121
GLY A   9
THR A  98
GLU A  77
 None
 0.88A 3fpjA-1pn3A:
3.9		 3fpjA-1pn3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 5 TYR A 225
ILE A 202
LEU A 301
PHE A 284
 None
None
TYD  A 406 (-4.6A)
None
 1.16A 3ls4L-1pn3A:
undetectable		 3ls4L-1pn3A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		5 / 11 THR A 365
LEU A 332
ALA A 302
GLN A 309
ILE A 307
 None
 1.26A 3qelA-1pn3A:
5.6
3qelB-1pn3A:
3.1		 3qelA-1pn3A:
19.45
3qelB-1pn3A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		5 / 12 GLY A 259
ALA A 261
ALA A 237
ALA A 240
ASP A 238
 None
 0.98A 3sudD-1pn3A:
undetectable		 3sudD-1pn3A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 8 TRP A 201
THR A 376
ARG A  23
LEU A  24
 None
 1.07A 3wipG-1pn3A:
0.0
3wipH-1pn3A:
0.0		 3wipG-1pn3A:
19.35
3wipH-1pn3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 8 ARG A  23
LEU A  24
TRP A 201
THR A 376
 None
 1.07A 3wipF-1pn3A:
0.0
3wipJ-1pn3A:
0.0		 3wipF-1pn3A:
19.35
3wipJ-1pn3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 8 VAL A 108
TYR A 119
VAL A  86
LEU A  17
 None
 0.92A 4jq1B-1pn3A:
undetectable		 4jq1B-1pn3A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 7 TYR A 121
LEU A 185
THR A 299
THR A 198
 None
 0.92A 4mbsA-1pn3A:
undetectable		 4mbsA-1pn3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		5 / 12 ARG A 328
SER A 186
VAL A 334
MET A 303
LEU A 179
 None
 1.40A 4o8fA-1pn3A:
0.0		 4o8fA-1pn3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_B_QELB920_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		5 / 10 THR A 365
LEU A 332
ALA A 302
GLN A 309
ILE A 307
 None
 1.27A 4pe5A-1pn3A:
4.7
4pe5B-1pn3A:
3.3		 4pe5A-1pn3A:
19.37
4pe5B-1pn3A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PE5_C_QELC939_1
(GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		5 / 10 THR A 365
LEU A 332
ALA A 302
GLN A 309
ILE A 307
 None
 1.26A 4pe5C-1pn3A:
1.3
4pe5D-1pn3A:
2.0		 4pe5C-1pn3A:
19.37
4pe5D-1pn3A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_B_QELB503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		5 / 11 THR A 365
LEU A 332
ALA A 302
GLN A 309
ILE A 307
 None
 1.18A 5ewjA-1pn3A:
4.3
5ewjB-1pn3A:
2.0		 5ewjA-1pn3A:
19.91
5ewjB-1pn3A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		5 / 12 THR A 365
LEU A 332
ALA A 302
GLN A 309
ILE A 307
 None
 1.22A 5ewjC-1pn3A:
undetectable
5ewjD-1pn3A:
2.7		 5ewjC-1pn3A:
19.91
5ewjD-1pn3A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		5 / 8 THR A 354
LEU A 352
PRO A 308
ILE A 310
LEU A 348
 None
 1.18A 5g48A-1pn3A:
undetectable		 5g48A-1pn3A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		5 / 9 THR A 354
LEU A 352
PRO A 308
ILE A 310
LEU A 348
 None
 1.19A 5g48B-1pn3A:
0.0		 5g48B-1pn3A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 1pn3 GLYCOSYLTRANSFERASE
GTFA
(Amycolatopsis
orientalis) 		4 / 5 ALA A 112
GLY A  92
CYH A  93
LYS A   1
 None
 1.45A 5jliA-1pn3A:
undetectable		 5jliA-1pn3A:
15.65