SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		5 / 10 HIS A  73
HIS A  76
LEU A  21
LEU A  47
THR A  49
 None
 1.29A 1rj6B-1pn4A:
undetectable		 1rj6B-1pn4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9A_A_BEZA306_0
(CHLOROCATECHOL
1,2-DIOXYGENASE)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		5 / 11 LEU A 211
GLY A 205
TYR A 177
TYR A  17
HIS A  46
 None
HDC  A1277 (-3.4A)
None
None
None
 1.44A 1s9aA-1pn4A:
undetectable		 1s9aA-1pn4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		3 / 3 ASN A  51
TRP A   7
GLN A  56
 None
None
HDC  A1277 ( 4.6A)
 0.99A 1xoqA-1pn4A:
undetectable		 1xoqA-1pn4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		4 / 8 MET A 206
ASP A 182
TYR A 177
HIS A  46
 None
HDC  A1277 (-2.8A)
None
None
 1.36A 2bteA-1pn4A:
undetectable		 2bteA-1pn4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		4 / 8 MET A 206
ASP A 182
TYR A 177
HIS A  46
 None
HDC  A1277 (-2.8A)
None
None
 1.34A 2bteD-1pn4A:
undetectable		 2bteD-1pn4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		4 / 7 MET A 206
ASP A 182
TYR A 177
HIS A  46
 None
HDC  A1277 (-2.8A)
None
None
 1.36A 2bytA-1pn4A:
undetectable		 2bytA-1pn4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		4 / 7 MET A 206
ASP A 182
TYR A 177
HIS A  46
 None
HDC  A1277 (-2.8A)
None
None
 1.36A 2bytD-1pn4A:
undetectable		 2bytD-1pn4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		5 / 6 VAL A 169
SER A 212
LEU A  47
ILE A 226
LEU A 203
 None
 1.43A 3kk6B-1pn4A:
undetectable		 3kk6B-1pn4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		3 / 3 ASP A 117
GLU A  90
GLY A  89
 None
 0.68A 3w9tA-1pn4A:
undetectable		 3w9tA-1pn4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		4 / 8 MET A 222
LEU A  21
ALA A 213
LEU A 211
 None
 0.95A 4ik6B-1pn4A:
undetectable		 4ik6B-1pn4A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		5 / 12 LEU A  21
HIS A  46
LEU A 176
LEU A 179
GLY A 181
 None
 1.19A 4l9qB-1pn4A:
undetectable		 4l9qB-1pn4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		5 / 11 HIS A  73
HIS A  76
LEU A  21
LEU A  47
THR A  49
 None
 1.22A 4lu3A-1pn4A:
undetectable		 4lu3A-1pn4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		4 / 4 GLY A 104
LEU A  63
PHE A  66
ILE A 133
 None
 0.98A 4xv2A-1pn4A:
undetectable		 4xv2A-1pn4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		5 / 9 ILE A  91
PHE A   9
GLY A  89
ILE A 124
GLU A 122
 None
 1.33A 4yp2B-1pn4A:
undetectable		 4yp2B-1pn4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		5 / 10 ILE A 109
PHE A 132
GLY A 104
ALA A 138
ASP A 139
 None
HDC  A1277 (-3.9A)
None
None
None
 1.49A 5ajqB-1pn4A:
undetectable		 5ajqB-1pn4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		5 / 9 ILE A  91
PHE A   9
GLY A  89
ILE A 124
GLU A 122
 None
 1.35A 5cf9B-1pn4A:
undetectable		 5cf9B-1pn4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		5 / 10 ALA A  60
PHE A  59
THR A 130
PRO A  68
LEU A  71
 None
None
HDC  A1277 ( 4.9A)
EDO  A 504 (-4.6A)
EDO  A 504 (-4.1A)
 1.45A 5mm4B-1pn4A:
undetectable		 5mm4B-1pn4A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		3 / 3 TYR A 209
ALA A 215
LEU A 216
 None
 0.68A 6ag0C-1pn4A:
undetectable		 6ag0C-1pn4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE
(Candida
tropicalis) 		5 / 10 GLY A 210
LEU A 211
CYH A 207
ALA A 265
LEU A 203
 None
 0.89A 6czmA-1pn4A:
undetectable
6czmC-1pn4A:
undetectable		 6czmA-1pn4A:
20.50
6czmC-1pn4A:
20.50