SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pn9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		5 / 12 PHE A 117
ALA A 164
ALA A 169
ALA A 161
GLY A 199
 None
 1.00A 2igtA-1pn9A:
undetectable		 2igtA-1pn9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		5 / 12 PHE A 117
ALA A 164
ALA A 169
ALA A 161
GLY A 199
 None
 0.99A 2igtB-1pn9A:
undetectable		 2igtB-1pn9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		5 / 12 SER A 158
PRO A  53
VAL A  15
GLN A  69
LEU A  72
 None
GTX  A 301 (-4.4A)
None
None
None
 1.38A 2xrlA-1pn9A:
0.2		 2xrlA-1pn9A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		4 / 4 ARG A  66
ASP A  80
GLY A  77
THR A  18
 GTX  A 301 (-3.6A)
None
None
None
 1.24A 3k4vB-1pn9A:
undetectable		 3k4vB-1pn9A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		4 / 6 GLN A  69
PHE A   3
PRO A  53
LEU A  55
 None
None
GTX  A 301 (-4.4A)
None
 1.21A 3tgvB-1pn9A:
undetectable		 3tgvB-1pn9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		4 / 7 LEU A 152
ASP A 100
VAL A  93
ILE A  68
 None
 0.97A 4eyrA-1pn9A:
undetectable		 4eyrA-1pn9A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		3 / 3 ARG A 185
ASP A 151
ASP A  79
 None
 0.55A 4kicB-1pn9A:
0.2		 4kicB-1pn9A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		4 / 4 ASP A 201
GLY A   8
PRO A   7
GLN A  16
 None
 1.30A 4oltA-1pn9A:
0.0		 4oltA-1pn9A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		4 / 5 ASP A 172
PHE A 173
PHE A 171
VAL A 134
 None
 1.09A 5a1rA-1pn9A:
undetectable		 5a1rA-1pn9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		5 / 12 GLY A 199
VAL A 168
ALA A  10
ALA A  14
MET A  17
 None
 1.07A 5n0tB-1pn9A:
undetectable		 5n0tB-1pn9A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 1pn9 GLUTATHIONE
S-TRANSFERASE 1-6
(Anopheles
gambiae) 		4 / 6 ALA A 160
LYS A 187
GLN A 197
ASP A 201
 None
 1.49A 5y9aA-1pn9A:
undetectable		 5y9aA-1pn9A:
24.46