SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1po0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		4 / 8 SER A 140
ARG A 365
ALA A 144
PHE A 333
 None
FLC  A 742 (-2.9A)
None
None
 0.94A 1dmiA-1po0A:
0.0
1dmiB-1po0A:
0.0		 1dmiA-1po0A:
20.84
1dmiB-1po0A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 12 VAL A 208
GLY A 209
LEU A 152
GLY A 516
VAL A 628
 None
 0.86A 1fduA-1po0A:
undetectable		 1fduA-1po0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 12 VAL A 208
GLY A 209
GLY A 516
PHE A 562
VAL A 628
 None
 1.16A 1fduC-1po0A:
undetectable		 1fduC-1po0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 12 VAL A 208
GLY A 209
LEU A 152
GLY A 516
VAL A 628
 None
 0.90A 1fduC-1po0A:
undetectable		 1fduC-1po0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		4 / 8 GLY A 175
TRP A 383
TYR A 474
GLU A 417
 None
None
None
FLC  A 743 ( 4.8A)
 1.08A 1jlfA-1po0A:
undetectable
1jlfB-1po0A:
undetectable		 1jlfA-1po0A:
22.38
1jlfB-1po0A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		3 / 3 GLU A 403
LYS A  81
VAL A  84
 None
 0.92A 1l2iA-1po0A:
undetectable		 1l2iA-1po0A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 10 GLY A 102
ALA A 103
ILE A 149
GLY A 210
VAL A 106
 None
 0.92A 1t3rA-1po0A:
undetectable		 1t3rA-1po0A:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 12 GLY A 312
GLY A 313
GLY A 724
ASP A 720
SER A 140
 None
None
None
FLC  A 742 (-4.1A)
None
 1.11A 1wg8B-1po0A:
undetectable		 1wg8B-1po0A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		4 / 5 LEU A 124
GLY A 151
PRO A 133
ALA A 132
 None
 0.97A 2aohA-1po0A:
undetectable		 2aohA-1po0A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 12 ALA A 608
GLY A 639
GLY A 595
LEU A 594
LEU A 597
 None
 1.08A 2hw2A-1po0A:
0.0		 2hw2A-1po0A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		4 / 5 LEU A 411
ILE A 471
SER A 473
GLY A 443
 None
 1.01A 2otfA-1po0A:
undetectable		 2otfA-1po0A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		3 / 3 ARG A 159
GLN A 176
PRO A 177
 None
FLC  A 743 (-3.8A)
None
 0.98A 2qhfA-1po0A:
undetectable		 2qhfA-1po0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		4 / 6 ASN A 146
ALA A 144
HIS A 141
ASP A 142
 None
 1.37A 3aruA-1po0A:
undetectable		 3aruA-1po0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		3 / 3 ARG A 196
GLU A 512
ASP A 452
 None
 0.79A 3g2oA-1po0A:
undetectable		 3g2oA-1po0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		4 / 7 ARG A 279
ASP A 305
ARG A 332
TRP A 334
 None
 1.25A 3kivA-1po0A:
0.0		 3kivA-1po0A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 10 GLY A 102
ALA A 103
ILE A 149
GLY A 210
VAL A 106
 None
 0.97A 3lzvA-1po0A:
undetectable		 3lzvA-1po0A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 12 GLU A 587
GLY A 197
ALA A 103
GLU A 541
ALA A 200
 None
 1.34A 3nmuA-1po0A:
0.0
3nmuF-1po0A:
undetectable		 3nmuA-1po0A:
20.35
3nmuF-1po0A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 10 GLY A 102
ALA A 103
GLY A 210
VAL A 211
VAL A 106
 None
 1.05A 3oxwA-1po0A:
undetectable		 3oxwA-1po0A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 11 THR A 115
GLY A 685
VAL A 705
GLU A 230
ILE A 708
 None
 1.23A 3uawA-1po0A:
undetectable		 3uawA-1po0A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 10 THR A 115
GLY A 685
VAL A 705
GLU A 230
ILE A 708
 None
 1.25A 3uayA-1po0A:
undetectable		 3uayA-1po0A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD391_1
(TETX2 PROTEIN)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 11 MET A 145
PHE A 147
GLY A 148
SER A 160
ASN A 213
 None
 1.17A 4a99D-1po0A:
0.9		 4a99D-1po0A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJH_A_SAMA302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 12 GLU A 230
THR A 119
ASN A 125
LYS A 706
GLN A 736
 None
 1.46A 4njhA-1po0A:
undetectable		 4njhA-1po0A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		3 / 3 ASP A 654
ASN A 707
SER A 657
 None
 0.84A 4obwA-1po0A:
undetectable		 4obwA-1po0A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 11 GLN A 176
GLY A 204
TYR A 520
SER A 207
GLU A 535
 FLC  A 743 (-3.8A)
None
None
None
None
 1.38A 4rv6A-1po0A:
undetectable		 4rv6A-1po0A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 11 GLN A 176
GLY A 204
TYR A 520
SER A 207
GLU A 535
 FLC  A 743 (-3.8A)
None
None
None
None
 1.38A 4rv6B-1po0A:
undetectable		 4rv6B-1po0A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_I_DIFI1006_1
(SERUM ALBUMIN)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 10 TRP A  88
ARG A 545
ARG A 150
ILE A 127
ALA A 103
 None
 1.40A 4z69I-1po0A:
undetectable		 4z69I-1po0A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		4 / 7 ALA A  92
GLY A 102
THR A 539
GLU A 541
 None
 1.02A 5btdA-1po0A:
0.0
5btdB-1po0A:
undetectable
5btdC-1po0A:
0.0		 5btdA-1po0A:
20.94
5btdB-1po0A:
17.14
5btdC-1po0A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 7 ARG A 121
ALA A 132
ASP A 271
ARG A 273
GLY A 728
 None
 1.49A 5btgA-1po0A:
undetectable
5btgC-1po0A:
undetectable
5btgD-1po0A:
undetectable		 5btgA-1po0A:
20.94
5btgC-1po0A:
20.94
5btgD-1po0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		3 / 3 THR A 138
HIS A 141
ASN A 135
 FLC  A 742 (-2.7A)
None
None
 1.00A 5n4tA-1po0A:
0.0		 5n4tA-1po0A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		3 / 3 THR A 461
HIS A 500
ASN A 459
 None
 0.84A 5n4tA-1po0A:
0.0		 5n4tA-1po0A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		3 / 3 ARG A 591
ARG A 126
ARG A 108
 None
 0.82A 5vcgA-1po0A:
0.0		 5vcgA-1po0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		3 / 3 MET A 189
ASP A 165
ARG A 337
 None
 1.17A 5z6kA-1po0A:
undetectable		 5z6kA-1po0A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		4 / 5 TYR A 713
GLN A 711
GLY A 724
ILE A 715
 None
 1.47A 6debB-1po0A:
undetectable		 6debB-1po0A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		3 / 3 LEU A 179
ASN A 213
LEU A 124
 None
 0.66A 6exiA-1po0A:
undetectable		 6exiA-1po0A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 1po0 IRON(III) DICITRATE
TRANSPORT PROTEIN
FECA PRECURSOR
(Escherichia
coli) 		5 / 12 LEU A 300
ALA A 218
LEU A  89
ARG A  93
ASP A  91
 None
 1.29A 6ie8A-1po0A:
undetectable		 6ie8A-1po0A:
14.15