SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1poi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 9 LEU A  40
VAL A  36
ILE A  11
VAL A  15
ILE A  21
 None
 1.33A 1gebA-1poiA:
undetectable		 1gebA-1poiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		6 / 9 VAL B  27
ILE B  21
GLY B  37
ILE B  36
VAL B  53
ILE B  51
 None
 1.07A 1ohrB-1poiB:
undetectable		 1ohrB-1poiB:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		4 / 7 ASP A 100
ASN A  72
PHE A  87
SER B 121
 None
 1.15A 1rqpB-1poiA:
undetectable		 1rqpB-1poiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		4 / 8 ASP A 100
ASN A  72
PHE A  87
SER B 121
 None
 1.17A 1rqpC-1poiA:
undetectable		 1rqpC-1poiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		4 / 8 ASP A 100
ASN A  72
PHE A  87
SER B 121
 None
 1.15A 1rqpA-1poiA:
undetectable		 1rqpA-1poiA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 THR B 225
GLY B 196
THR B 215
PRO B 218
ALA B 234
 None
 1.41A 1vq1A-1poiB:
undetectable		 1vq1A-1poiB:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 9 ILE B  21
GLY B  37
ILE B  36
VAL B  53
ILE B  51
 None
 0.98A 2avoA-1poiB:
undetectable		 2avoA-1poiB:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 PHE A 196
ASN B  84
GLY B  70
ASP A  29
ASP A 198
 None
 1.13A 2fqyA-1poiA:
undetectable		 2fqyA-1poiA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 5 SER B 119
VAL B 117
SER B 135
SER B 167
 None
 0.95A 2j9cA-1poiB:
undetectable
2j9cB-1poiB:
undetectable
2j9cC-1poiB:
undetectable		 2j9cA-1poiB:
17.21
2j9cB-1poiB:
17.21
2j9cC-1poiB:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 5 SER B 167
SER B 119
VAL B 117
SER B 135
 None
 0.96A 2j9cA-1poiB:
undetectable
2j9cB-1poiB:
undetectable
2j9cC-1poiB:
undetectable		 2j9cA-1poiB:
17.21
2j9cB-1poiB:
17.21
2j9cC-1poiB:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 7 SER B 167
SER B 119
VAL B 117
SER B 135
 None
 0.96A 2j9cA-1poiB:
undetectable
2j9cB-1poiB:
undetectable
2j9cC-1poiB:
undetectable		 2j9cA-1poiB:
17.21
2j9cB-1poiB:
17.21
2j9cC-1poiB:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 11 GLY B 134
GLY B 107
ILE B 106
THR B  31
VAL B  69
 None
 0.96A 2nnpA-1poiB:
undetectable		 2nnpA-1poiB:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		6 / 12 VAL B  27
ILE B  21
GLY B  37
ILE B  36
VAL B  53
ILE B  51
 None
 1.19A 2o4kB-1poiB:
undetectable		 2o4kB-1poiB:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		6 / 12 VAL B  27
ILE B  21
GLY B  37
ILE B  36
VAL B  53
ILE B  51
 None
 1.09A 2q64B-1poiB:
undetectable		 2q64B-1poiB:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		4 / 8 ASP A 100
ASN A  72
PHE A  87
SER B 121
 None
 1.17A 2v7uA-1poiA:
undetectable		 2v7uA-1poiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		4 / 7 ASP A 100
ASN A  72
PHE A  87
SER B 121
 None
 1.16A 2v7uB-1poiA:
undetectable		 2v7uB-1poiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 9 ILE B  21
PHE B 105
ALA B 104
VAL B  27
 None
 0.80A 2vufA-1poiB:
undetectable		 2vufA-1poiB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 GLY B 134
GLY B 107
ILE B 106
THR B  31
VAL B  69
 None
 0.83A 3d1xA-1poiB:
undetectable		 3d1xA-1poiB:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 GLY B 134
GLY B 107
ILE B 106
THR B  31
VAL B  69
 None
 0.88A 3d1yA-1poiB:
undetectable		 3d1yA-1poiB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 9 ILE B  21
GLY B  37
ILE B  36
VAL B  53
ILE B  51
 None
 0.91A 3d1yB-1poiB:
undetectable		 3d1yB-1poiB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		3 / 3 THR A  27
SER A  78
PHE A  87
 None
 0.69A 3d4sA-1poiA:
undetectable		 3d4sA-1poiA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 9 VAL B  27
ILE B  21
GLY B  37
ILE B  36
ILE B  51
 None
 1.03A 3ekqB-1poiB:
undetectable		 3ekqB-1poiB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 9 ASP A 174
ILE A  21
GLY A  49
ILE A  71
ILE A 201
 None
 1.09A 3ekyB-1poiA:
undetectable		 3ekyB-1poiA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 9 ILE B  21
GLY B  37
ILE B  36
VAL B  53
ILE B  51
 None
 0.98A 3ekyB-1poiB:
undetectable		 3ekyB-1poiB:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		6 / 12 VAL B  27
ILE B  21
GLY B  37
ILE B  36
VAL B  53
ILE B  51
 None
 1.04A 3el1B-1poiB:
undetectable		 3el1B-1poiB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 10 PHE A  87
GLY A  52
GLY A  51
TYR A  70
ASN A  72
 None
 1.34A 3fw1A-1poiA:
undetectable		 3fw1A-1poiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		5 / 12 GLY A 127
LEU A 130
LEU A 124
ASP A 104
GLY B 169
 None
 1.06A 3g2oB-1poiA:
undetectable		 3g2oB-1poiA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		6 / 12 VAL B  27
ILE B  21
GLY B  37
ILE B  36
VAL B  53
ILE B  51
 None
 1.14A 3k4vB-1poiB:
undetectable		 3k4vB-1poiB:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 9 ASP A 174
ILE A  21
GLY A  49
ILE A  71
ILE A 201
 None
 1.05A 3ndwB-1poiA:
undetectable		 3ndwB-1poiA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 6 ILE B 259
GLU B  11
ALA B  14
ASN B   9
 None
 1.13A 3pgyA-1poiB:
3.2
3pgyB-1poiB:
2.8		 3pgyA-1poiB:
21.88
3pgyB-1poiB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		3 / 3 THR B 143
ASP A 104
GLU B  54
 None
 0.71A 3qowA-1poiB:
2.1		 3qowA-1poiB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 11 LEU A 130
THR B 166
ASN B 139
GLY B 140
ASP A 104
 None
 1.23A 3sfuC-1poiA:
undetectable		 3sfuC-1poiA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 10 TYR A 207
ILE A 209
VAL A 175
ASP A  19
ILE A  44
 None
 1.45A 3uprA-1poiA:
undetectable		 3uprA-1poiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 10 TYR A 207
ILE A 209
VAL A 175
ASP A  19
ILE A  44
 None
 1.48A 3uprC-1poiA:
undetectable		 3uprC-1poiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 8 TYR A 244
TYR A 255
HIS A 179
LEU A 241
 None
 1.30A 3uzzB-1poiA:
undetectable		 3uzzB-1poiA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		6 / 12 TYR A 207
ILE A 209
VAL A 175
ASP A  19
ILE A  44
ILE A  11
 None
 1.47A 3vrjA-1poiA:
undetectable
3vrjC-1poiA:
undetectable		 3vrjA-1poiA:
20.00
3vrjC-1poiA:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		3 / 3 TYR A 257
MET A 316
LEU A 310
 None
 0.91A 3vw1D-1poiA:
0.0		 3vw1D-1poiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		3 / 3 GLU B 236
TYR B 212
SER B 217
 None
 0.90A 4at0A-1poiB:
undetectable		 4at0A-1poiB:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 ALA A  22
LEU A  23
VAL A  67
LEU A  61
ILE A  44
 None
 1.09A 4g1bA-1poiA:
2.0		 4g1bA-1poiA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 8 GLY B 169
ASN B 116
MET B 207
ILE B 149
 None
 0.83A 4j4vC-1poiB:
undetectable		 4j4vC-1poiB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 6 VAL B  88
SER A 102
ALA A  53
PHE A  26
 None
 1.24A 4nedA-1poiB:
undetectable		 4nedA-1poiB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 VAL A 189
GLY A 194
ASP A  29
GLY A  24
ILE A 178
 None
 1.03A 4q5mA-1poiA:
undetectable		 4q5mA-1poiA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 11 GLY B 134
GLY B 107
ILE B 106
THR B  31
VAL B  69
 None
 0.90A 4qgiA-1poiB:
undetectable		 4qgiA-1poiB:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 7 THR A  27
GLY A  25
GLY A  24
ILE A 201
 None
 0.46A 4yjiA-1poiA:
0.0		 4yjiA-1poiA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 7 ILE B 171
LYS B 205
GLY B 175
GLY B 176
 None
 0.82A 5a06A-1poiB:
3.4		 5a06A-1poiB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 7 ILE B 171
LYS B 205
GLY B 175
GLY B 176
 None
 0.84A 5a06C-1poiB:
3.5		 5a06C-1poiB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 7 ILE B 171
LYS B 205
GLY B 175
GLY B 176
 None
 0.85A 5a06E-1poiB:
2.8		 5a06E-1poiB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 7 ILE B 171
LYS B 205
GLY B 175
GLY B 176
 None
 0.83A 5a06F-1poiB:
3.3		 5a06F-1poiB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		3 / 3 VAL A 173
LEU A  96
MET A  98
 None
 0.90A 5ikrA-1poiA:
0.0		 5ikrA-1poiA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		3 / 3 ARG B 206
PRO B 113
ASN B 160
 None
 0.82A 5jwaA-1poiB:
undetectable
5jwaH-1poiB:
undetectable		 5jwaA-1poiB:
20.68
5jwaH-1poiB:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 GLY B 134
GLY B 107
ILE B 106
THR B  31
VAL B  69
 None
 0.88A 5kqxA-1poiB:
undetectable		 5kqxA-1poiB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 9 VAL B  27
ILE B  21
GLY B  37
ILE B  36
ILE B  51
 None
 0.92A 5kqxB-1poiB:
undetectable		 5kqxB-1poiB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 8 TYR A  33
CYH A 279
TYR A 265
LEU A  40
 None
 1.44A 5kxiA-1poiA:
undetectable
5kxiB-1poiA:
undetectable		 5kxiA-1poiA:
20.94
5kxiB-1poiA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 8 TYR A  33
CYH A 279
TYR A 265
LEU A  40
 None
 1.40A 5kxiD-1poiA:
0.0
5kxiE-1poiA:
undetectable		 5kxiD-1poiA:
20.94
5kxiE-1poiA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 7 GLY B 187
GLY B 169
LEU B 190
THR B 147
 None
 0.77A 5o96C-1poiB:
undetectable		 5o96C-1poiB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 10 GLY B 187
GLY B 169
VAL B 191
LEU B 190
THR B 147
 None
 0.91A 5o96G-1poiB:
undetectable
5o96H-1poiB:
undetectable		 5o96G-1poiB:
19.93
5o96H-1poiB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 10 TYR A 207
ILE A 209
VAL A 175
ASP A  19
ILE A  44
 None
 1.49A 5u98A-1poiA:
undetectable		 5u98A-1poiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 10 TYR A 207
ILE A 209
VAL A 175
ASP A  19
ILE A  44
 None
 1.47A 5u98D-1poiA:
undetectable		 5u98D-1poiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 10 GLY B 187
GLY B 169
TRP B 170
LEU B 190
THR B 147
 None
 1.05A 5vm8B-1poiB:
undetectable		 5vm8B-1poiB:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		6 / 12 GLY A  24
ASP A 198
ILE A 191
VAL A 189
ILE A 209
HIS A 179
 None
 1.37A 5wy0A-1poiA:
undetectable		 5wy0A-1poiA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		3 / 3 GLN A 197
TRP A 110
VAL A 173
 None
 1.03A 6auuA-1poiA:
undetectable		 6auuA-1poiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 VAL A 105
ARG A 141
GLY A 135
THR A  48
GLY A  49
 None
 1.19A 6brdC-1poiA:
undetectable		 6brdC-1poiA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 7 TYR A  33
CYH A 279
TYR A 265
LEU A  40
 None
 1.18A 6cnjA-1poiA:
0.0
6cnjB-1poiA:
0.0		 6cnjA-1poiA:
11.64
6cnjB-1poiA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 7 TYR A  33
CYH A 279
TYR A 265
LEU A  40
 None
 1.16A 6cnkB-1poiA:
undetectable
6cnkC-1poiA:
undetectable		 6cnkB-1poiA:
11.64
6cnkC-1poiA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		6 / 12 VAL B  27
ILE B  21
GLY B  37
ILE B  36
VAL B  53
ILE B  51
 None
 1.03A 6dilB-1poiB:
undetectable		 6dilB-1poiB:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 LEU A 301
LEU A 304
ALA A  34
LEU A 293
ARG A 300
 None
 1.06A 6ew0B-1poiA:
undetectable		 6ew0B-1poiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 LEU A 301
LEU A 304
ALA A  34
LEU A 293
ARG A 300
 None
 1.07A 6ew0D-1poiA:
undetectable		 6ew0D-1poiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 LEU A 301
LEU A 304
ALA A  34
LEU A 293
ARG A 300
 None
 1.07A 6ew0H-1poiA:
undetectable		 6ew0H-1poiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		5 / 12 LEU A 301
LEU A 304
ALA A  34
LEU A 293
ARG A 300
 None
 1.06A 6ew0I-1poiA:
undetectable		 6ew0I-1poiA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		4 / 6 GLU A  99
ARG A 141
VAL A 168
PRO A 169
 None
 1.39A 6fgdA-1poiA:
undetectable		 6fgdA-1poiA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		3 / 3 TYR A 107
ASP A 104
GLN A 103
 None
 0.96A 6g1pA-1poiA:
undetectable		 6g1pA-1poiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1poi GLUTACONATE COENZYME
A-TRANSFERASE
(Acidaminococcus
fermentans) 		3 / 3 THR B 143
GLU B  54
ASN B 139
 None
 0.72A 6nj9K-1poiB:
undetectable		 6nj9K-1poiB:
19.00