SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1poy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		4 / 8 LEU 1 154
TRP 1 155
ASP 1 153
THR 1 134
 None
 1.06A 1rmtD-1poy1:
undetectable		 1rmtD-1poy1:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		4 / 4 LEU 1  29
PRO 1  82
ILE 1 275
LEU 1 274
 None
 1.05A 1ya4B-1poy1:
0.8		 1ya4B-1poy1:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		4 / 4 LEU 1  29
PRO 1  82
ILE 1 275
LEU 1 274
 None
 1.15A 1ya4C-1poy1:
0.9		 1ya4C-1poy1:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		5 / 12 TYR 1 293
GLY 1 132
THR 1 134
GLU 1 171
ILE 1 130
 SPD  1 400 ( 4.6A)
None
None
SPD  1 400 (-3.5A)
None
 1.34A 2azxA-1poy1:
undetectable		 2azxA-1poy1:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		5 / 12 TYR 1 293
GLY 1 132
THR 1 134
GLU 1 171
ILE 1 130
 SPD  1 400 ( 4.6A)
None
None
SPD  1 400 (-3.5A)
None
 1.34A 2azxB-1poy1:
undetectable		 2azxB-1poy1:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		5 / 12 GLU 1  36
LEU 1 304
GLY 1 292
SER 1 232
ILE 1 291
 SPD  1 400 (-3.5A)
None
None
None
None
 1.25A 2e7fA-1poy1:
undetectable		 2e7fA-1poy1:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		3 / 3 TYR 1  59
VAL 1  80
THR 1  58
 None
 0.84A 2ygnA-1poy1:
undetectable		 2ygnA-1poy1:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		5 / 10 ILE 1 243
ILE 1 291
ILE 1 130
ASN 1 230
VAL 1 245
 None
 1.32A 3ohtA-1poy1:
0.0
3ohtB-1poy1:
0.0		 3ohtA-1poy1:
22.50
3ohtB-1poy1:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		3 / 3 PHE 1 119
SER 1 258
SER 1 126
 None
 0.92A 3ufgB-1poy1:
undetectable		 3ufgB-1poy1:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		5 / 12 GLY 1 137
VAL 1 223
ASN 1 216
ASN 1 213
SER 1 232
 None
 1.14A 4pd5A-1poy1:
undetectable		 4pd5A-1poy1:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		3 / 3 ASP 1 168
SER 1  83
TYR 1  85
 SPD  1 400 (-3.6A)
SPD  1 400 ( 3.7A)
None
 0.77A 5glmA-1poy1:
0.0		 5glmA-1poy1:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		4 / 8 LEU 1 110
LEU 1 104
TYR 1 129
GLN 1 286
 None
 1.14A 5hbsA-1poy1:
undetectable		 5hbsA-1poy1:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN
(Escherichia
coli) 		3 / 3 SER 1 150
LEU 1 165
MET 1 227
 None
 0.72A 5ikrB-1poy1:
undetectable		 5ikrB-1poy1:
19.13