SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		4 / 6 ASP R  42
TYR R 117
ASP R 114
GLU R 131
 None
 1.28A 1rjdB-1pp2R:
undetectable		 1rjdB-1pp2R:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		4 / 6 ASP R  42
TYR R 117
ASP R 114
GLU R 131
 None
 1.26A 1rjdC-1pp2R:
undetectable		 1rjdC-1pp2R:
15.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		6 / 7 GLY R  30
HIS R  48
ASP R  49
TYR R  52
PRO R  68
LYS R  69
 None
 1.29A 1th6A-1pp2R:
21.3		 1th6A-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		6 / 7 GLY R  30
TRP R  31
HIS R  48
ASP R  49
TYR R  52
PRO R  68
 None
 1.41A 1th6A-1pp2R:
21.3		 1th6A-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		5 / 12 LEU R   2
GLY R  18
TYR R  52
PRO R  68
LYS R  69
 None
 1.09A 1y4lA-1pp2R:
19.9		 1y4lA-1pp2R:
45.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		6 / 7 GLY R  30
HIS R  48
ASP R  49
TYR R  52
PRO R  68
LYS R  69
 None
 1.28A 2armA-1pp2R:
21.4		 2armA-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		6 / 7 GLY R  30
TRP R  31
HIS R  48
ASP R  49
TYR R  52
PRO R  68
 None
 1.42A 2armA-1pp2R:
21.4		 2armA-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		6 / 10 LEU R   2
GLY R  30
HIS R  48
ASP R  49
LYS R  69
PHE R 106
 None
 1.05A 2b17A-1pp2R:
21.5		 2b17A-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		4 / 6 LEU R   2
HIS R  48
ASP R  49
TYR R  52
 None
 0.71A 2dpzA-1pp2R:
21.3		 2dpzA-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		4 / 5 LEU R   2
SER R  23
GLY R  30
HIS R  48
 None
 0.87A 2otfA-1pp2R:
21.5		 2otfA-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		3 / 3 ASP R  49
TYR R  52
LYS R  69
 None
 0.88A 2othA-1pp2R:
21.4		 2othA-1pp2R:
54.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		4 / 8 THR R  41
TYR R 113
ARG R 107
ILE R 110
 None
 1.13A 2xytH-1pp2R:
undetectable		 2xytH-1pp2R:
18.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		4 / 5 HIS R  48
ASP R  49
PRO R  68
LYS R  69
 None
 1.22A 3fo7A-1pp2R:
21.3		 3fo7A-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		4 / 5 HIS R  48
ASP R  49
TYR R  52
PRO R  68
 None
 0.75A 3fo7A-1pp2R:
21.3		 3fo7A-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		4 / 5 HIS R  48
ASP R  49
TYR R  52
PRO R  68
 None
 0.70A 3h1xA-1pp2R:
21.4		 3h1xA-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		5 / 9 LEU R   2
PHE R   5
ILE R   9
GLY R  30
HIS R  48
 None
 0.90A 3oshA-1pp2R:
17.4		 3oshA-1pp2R:
37.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_B_DM5B602_1
(SERUM ALBUMIN)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		5 / 9 VAL R  47
ALA R 102
PHE R 106
TYR R 113
TYR R  25
 None
 1.48A 4lb2B-1pp2R:
1.9		 4lb2B-1pp2R:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2
(Crotalus
atrox) 		4 / 4 VAL R  71
GLY R  92
ASP R  89
ASP R  59
 None
 1.13A 6cjkC-1pp2R:
undetectable		 6cjkC-1pp2R:
18.72