SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ppo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1ppo PROTEASE OMEGA
(Carica
papaya) 		7 / 10 GLN A  19
GLY A  23
SER A  24
PHE A  28
SER A  29
ALA A 160
GLY A  65
 HG  A 217 ( 4.7A)
None
None
None
None
None
None
 1.15A 1stfE-1ppoA:
38.3
1stfI-1ppoA:
undetectable		 1stfE-1ppoA:
67.13
1stfI-1ppoA:
17.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1ppo PROTEASE OMEGA
(Carica
papaya) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 159
ALA A 160
 HG  A 217 ( 4.7A)
None
None
None
None
None
HG  A 217 ( 3.6A)
None
 0.37A 1stfE-1ppoA:
38.3
1stfI-1ppoA:
undetectable		 1stfE-1ppoA:
67.13
1stfI-1ppoA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 1ppo PROTEASE OMEGA
(Carica
papaya) 		4 / 8 LEU A 121
TYR A 207
ILE A 175
ILE A 177
 None
 0.70A 2bu8A-1ppoA:
undetectable		 2bu8A-1ppoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1ppo PROTEASE OMEGA
(Carica
papaya) 		4 / 7 GLN A  19
GLY A  23
HIS A 159
TRP A 181
 HG  A 217 ( 4.7A)
None
HG  A 217 ( 3.6A)
None
 0.51A 3ai8A-1ppoA:
28.0		 3ai8A-1ppoA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1ppo PROTEASE OMEGA
(Carica
papaya) 		4 / 7 LEU A 122
ALA A 163
VAL A  13
ILE A 125
 None
 0.96A 3wsjB-1ppoA:
undetectable		 3wsjB-1ppoA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ppo PROTEASE OMEGA
(Carica
papaya) 		3 / 3 PHE A  28
VAL A 164
ILE A 177
 None
 0.60A 4emaA-1ppoA:
undetectable		 4emaA-1ppoA:
19.29