SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ppy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Escherichia
coli) 		5 / 11 ILE A  69
ILE A  87
MET A 114
GLY A  65
LEU A  33
 None
 1.13A 2azyA-1ppyA:
undetectable		 2azyA-1ppyA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Escherichia
coli) 		4 / 5 ALA A  59
ALA A  36
ALA A 106
VAL A  13
 None
 0.93A 2nyrB-1ppyA:
undetectable		 2nyrB-1ppyA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Escherichia
coli) 		4 / 7 TYR A  22
SER A  25
CYH A  26
ILE A  28
 None
 1.29A 2xz5A-1ppyA:
0.0
2xz5B-1ppyA:
0.0		 2xz5A-1ppyA:
20.47
2xz5B-1ppyA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Escherichia
coli) 		5 / 10 GLY A  65
ALA A  62
PHE A  32
PHE A 108
LEU A  10
 None
 1.39A 3a3yA-1ppyA:
undetectable		 3a3yA-1ppyA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Escherichia
coli) 		5 / 12 LEU A  10
ILE A  44
ASP A  45
ASN A 104
LEU A  33
 None
 1.42A 3cjtK-1ppyA:
undetectable		 3cjtK-1ppyA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ppy ASPARTATE
1-DECARBOXYLASE
PRECURSOR
(Escherichia
coli) 		4 / 7 TYR A  58
VAL A  71
ILE A  46
ILE A  87
 None
 0.83A 4lv9A-1ppyA:
undetectable		 4lv9A-1ppyA:
14.11