SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 5 TYR A  85
PRO A 111
LEU A 113
THR A  52
 None
 1.25A 1i2wA-1pq4A:
undetectable		 1i2wA-1pq4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9J_H_TESH1010_1
(RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN
RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT LIGHT
CHAIN)		 1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 11 SER A 128
VAL A 102
GLU A 109
LEU A 106
VAL A 187
 None
 1.37A 1i9jH-1pq4A:
undetectable
1i9jL-1pq4A:
undetectable		 1i9jH-1pq4A:
21.23
1i9jL-1pq4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 194
ALA A 195
ALA A 199
PRO A 203
ARG A 206
 None
 1.05A 2fr3A-1pq4A:
undetectable		 2fr3A-1pq4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A 312
ALA A 327
PHE A 249
ASN A 334
 None
 1.48A 3uq6A-1pq4A:
4.3		 3uq6A-1pq4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 4 LEU A 312
ALA A 327
PHE A 249
ASN A 334
 None
 1.48A 3vasA-1pq4A:
undetectable		 3vasA-1pq4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 234
LEU A 227
LEU A 231
ILE A 230
LEU A 323
 None
 0.96A 4zowA-1pq4A:
0.0		 4zowA-1pq4A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		5 / 12 PHE A 288
VAL A 287
ALA A 303
ALA A 302
GLY A 308
 None
 1.38A 5tzoA-1pq4A:
undetectable		 5tzoA-1pq4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 5 HIS A 243
HIS A 179
HIS A  83
PHE A 293
 ZN  A1002 (-3.2A)
ZN  A1002 (-3.3A)
ZN  A1002 (-3.1A)
None
 0.93A 5zrdB-1pq4A:
undetectable		 5zrdB-1pq4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 5 HIS A 243
HIS A 179
HIS A  83
PHE A 293
 ZN  A1002 (-3.2A)
ZN  A1002 (-3.3A)
ZN  A1002 (-3.1A)
None
 0.93A 5zrdC-1pq4A:
undetectable		 5zrdC-1pq4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1pq4 PERIPLASMIC BINDING
PROTEIN COMPONENT OF
AN ABC TYPE ZINC
UPTAKE TRANSPORTER
(Synechocystis
sp.
PCC
6803) 		4 / 5 HIS A 243
HIS A 179
HIS A  83
PHE A 293
 ZN  A1002 (-3.2A)
ZN  A1002 (-3.3A)
ZN  A1002 (-3.1A)
None
 0.96A 5zrdD-1pq4A:
undetectable		 5zrdD-1pq4A:
20.48