SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1prs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 11 LEU A 118
VAL A 138
LEU A 108
PRO A 110
TYR A 113
 None
 1.03A 1klmA-1prsA:
undetectable		 1klmA-1prsA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.92A 2f80B-1prsA:
undetectable		 2f80B-1prsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.92A 2f81B-1prsA:
undetectable		 2f81B-1prsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.91A 2ienB-1prsA:
undetectable		 2ienB-1prsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.85A 2o4lB-1prsA:
undetectable		 2o4lB-1prsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.86A 2pymA-1prsA:
undetectable		 2pymA-1prsA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.89A 2pymB-1prsA:
undetectable		 2pymB-1prsA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.88A 2pynA-1prsA:
undetectable		 2pynA-1prsA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.88A 2pynB-1prsA:
undetectable		 2pynB-1prsA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.90A 2q63B-1prsA:
undetectable		 2q63B-1prsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.94A 2qakB-1prsA:
undetectable		 2qakB-1prsA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 7 VAL A  84
ILE A   4
ALA A   2
VAL A  48
GLY A  22
 None
 1.43A 2xrzB-1prsA:
undetectable		 2xrzB-1prsA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.87A 3bvbB-1prsA:
undetectable		 3bvbB-1prsA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.90A 3d20B-1prsA:
undetectable		 3d20B-1prsA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.89A 3jvyA-1prsA:
undetectable		 3jvyA-1prsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.90A 3jvyB-1prsA:
undetectable		 3jvyB-1prsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.90A 3jw2A-1prsA:
undetectable		 3jw2A-1prsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 11 ALA A 157
LEU A 140
VAL A 138
ILE A 123
PHE A  95
 None
 1.31A 3jw5A-1prsA:
undetectable		 3jw5A-1prsA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.84A 3k4vB-1prsA:
undetectable		 3k4vB-1prsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_2
(PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.89A 3ndtD-1prsA:
undetectable		 3ndtD-1prsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.83A 3nduC-1prsA:
undetectable		 3nduC-1prsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 10 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.93A 3nu6B-1prsA:
undetectable		 3nu6B-1prsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.94A 3pwmB-1prsA:
undetectable		 3pwmB-1prsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.80A 3pwrB-1prsA:
undetectable		 3pwrB-1prsA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		3 / 3 PHE A 101
SER A 130
GLN A 100
 None
CA  A 175 (-3.2A)
None
 1.00A 3smtA-1prsA:
0.0		 3smtA-1prsA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_2
(PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.98A 3tkgD-1prsA:
undetectable		 3tkgD-1prsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.87A 3tl9B-1prsA:
undetectable		 3tl9B-1prsA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		3 / 3 LYS A 132
LEU A 108
ILE A 128
 None
 0.72A 5kc0A-1prsA:
undetectable		 5kc0A-1prsA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.82A 6difB-1prsA:
undetectable		 6difB-1prsA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 1prs DEVELOPMENT-SPECIFIC
PROTEIN S
(Myxococcus
xanthus) 		5 / 12 LEU A  19
GLY A  22
VAL A  44
VAL A   6
ILE A   4
 None
 0.84A 6dilB-1prsA:
undetectable		 6dilB-1prsA:
21.25