SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1prz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 8 ILE A  86
LEU A  84
ILE A  96
VAL A 148
ILE A  94
 None
 1.44A 1linA-1przA:
undetectable		 1linA-1przA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 8 GLY A 133
VAL A 148
MET A 146
ILE A 126
 None
 0.85A 1pk7B-1przA:
undetectable		 1pk7B-1przA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 10 ILE A 236
ALA A 173
LEU A 279
ALA A 278
ILE A 189
 None
 1.02A 3falC-1przA:
undetectable		 3falC-1przA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 11 ILE A 236
ALA A 173
LEU A 279
ALA A 278
ILE A 189
 None
 1.01A 3fc6A-1przA:
undetectable		 3fc6A-1przA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 8 GLY A 133
VAL A 129
ILE A  93
VAL A 147
 None
 0.76A 3fi0I-1przA:
undetectable		 3fi0I-1przA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 12 LEU A 284
ALA A 281
LEU A 138
ILE A 167
LEU A 228
 None
 1.29A 3olsB-1przA:
undetectable		 3olsB-1przA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 4 PRO A 289
LEU A 286
ILE A 167
ARG A 169
 None
 1.46A 3w1wA-1przA:
undetectable		 3w1wA-1przA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 4 ASN A  97
ALA A 299
GLY A 144
THR A 143
 None
 1.17A 4bboC-1przA:
undetectable		 4bboC-1przA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 6 GLU A  89
ILE A  93
HIS A 136
VAL A 104
 None
 1.07A 4ejwB-1przA:
undetectable		 4ejwB-1przA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 12 ASP A 139
ILE A 134
TYR A 171
LEU A 247
LEU A 226
 None
 1.27A 4j03A-1przA:
undetectable		 4j03A-1przA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 7 PRO A 302
VAL A 306
MET A 305
PHE A 274
 None
 1.04A 4lb2A-1przA:
undetectable		 4lb2A-1przA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		3 / 3 THR A 197
MET A 199
HIS A 192
 None
 0.94A 5uunA-1przA:
0.0		 5uunA-1przA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 8 GLY A 144
LEU A 138
LEU A 116
VAL A 104
ILE A 126
 None
 1.19A 5vkqB-1przA:
undetectable
5vkqC-1przA:
undetectable		 5vkqB-1przA:
9.08
5vkqC-1przA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 9 ASP A 250
LEU A 247
GLY A 249
PHE A 274
TYR A 253
 None
 1.33A 5x66C-1przA:
undetectable		 5x66C-1przA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		6 / 12 ASP A 250
LEU A 247
GLY A 249
PHE A 274
TYR A 253
THR A 222
 None
 1.47A 5x66F-1przA:
0.0		 5x66F-1przA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		4 / 5 HIS A 202
ALA A 200
SER A 190
GLY A 205
 None
 1.29A 5yodB-1przA:
undetectable		 5yodB-1przA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D
(Escherichia
coli) 		5 / 12 ILE A 236
ALA A 173
LEU A 279
ALA A 278
ILE A 189
 None
 0.96A 6a5zL-1przA:
undetectable		 6a5zL-1przA:
12.86