SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ps6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU A 273
PRO A 271
VAL A 272
ALA A 246
PHE A 250
 None
 1.15A 1gseA-1ps6A:
undetectable		 1gseA-1ps6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 12 LEU A 273
PRO A 271
VAL A 272
ALA A 246
PHE A 250
 None
 1.06A 1gseB-1ps6A:
undetectable		 1gseB-1ps6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 LEU A 181
VAL A 184
LEU A 188
 None
 0.41A 1mz9B-1ps6A:
undetectable		 1mz9B-1ps6A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 LEU A  75
PRO A  77
LEU A  76
ARG A   6
 None
 1.36A 2hrcA-1ps6A:
undetectable		 2hrcA-1ps6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		6 / 12 GLY A 281
GLY A 279
LEU A 273
ALA A 154
ARG A 159
VAL A 295
 None
 1.33A 2yqzA-1ps6A:
undetectable		 2yqzA-1ps6A:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 PRO A  77
LEU A  76
ARG A   6
 None
 0.75A 3aqiA-1ps6A:
4.9		 3aqiA-1ps6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 PRO A  77
LEU A  76
ARG A   6
 None
 0.85A 3aqiB-1ps6A:
undetectable		 3aqiB-1ps6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 6 TYR A  96
ALA A  79
LEU A  80
THR A  44
 None
 0.88A 3b6hA-1ps6A:
undetectable		 3b6hA-1ps6A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 VAL A  97
GLY A  16
ILE A  17
PRO A  11
THR A  10
 None
 1.14A 3el5A-1ps6A:
undetectable		 3el5A-1ps6A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 GLY A  12
VAL A  97
GLY A 135
THR A 134
 None
None
4TP  A 332 ( 4.0A)
None
 0.72A 3ib2A-1ps6A:
0.0		 3ib2A-1ps6A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 9 LEU A 192
LEU A 262
ILE A 185
ALA A 186
ALA A 161
 None
 1.05A 3mdvA-1ps6A:
undetectable		 3mdvA-1ps6A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 8 ILE A 315
GLU A  29
LEU A  34
VAL A  32
 None
 0.86A 3ua5A-1ps6A:
undetectable		 3ua5A-1ps6A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 ALA A  38
LEU A  42
GLY A  16
VAL A  97
GLY A  18
 None
 0.76A 3zosA-1ps6A:
undetectable
3zosB-1ps6A:
undetectable		 3zosA-1ps6A:
25.14
3zosB-1ps6A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ARG A  28
TRP A  30
ILE A 315
 None
 0.70A 4mwxA-1ps6A:
undetectable		 4mwxA-1ps6A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 LEU A  76
VAL A  36
LEU A 101
GLY A 119
LEU A 116
 None
 1.23A 4zbqA-1ps6A:
undetectable		 4zbqA-1ps6A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 PHE A 250
ALA A 246
GLY A 207
VAL A 160
LEU A 270
 None
None
None
None
4TP  A 332 (-4.8A)
 1.12A 4zmeA-1ps6A:
undetectable		 4zmeA-1ps6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 11 PHE A 250
GLY A 207
VAL A 160
LEU A 273
LEU A 270
 None
None
None
None
4TP  A 332 (-4.8A)
 1.17A 4zmeA-1ps6A:
undetectable		 4zmeA-1ps6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		5 / 10 ALA A 300
GLY A  18
LEU A  21
ALA A 309
ASP A 310
 None
 1.47A 5ajqB-1ps6A:
undetectable		 5ajqB-1ps6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 5 ALA A  26
PRO A  11
GLY A 135
LEU A 116
 None
None
4TP  A 332 ( 4.0A)
None
 1.02A 5eslA-1ps6A:
undetectable		 5eslA-1ps6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		3 / 3 ILE A 185
ILE A 226
MET A 238
 None
 0.67A 5i9yA-1ps6A:
undetectable		 5i9yA-1ps6A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE
(Escherichia
coli) 		4 / 4 GLN A   5
THR A   4
GLU A  33
LEU A 318
 None
 1.38A 5m66A-1ps6A:
2.2		 5m66A-1ps6A:
20.08