SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ps9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.40A 1c9sA-1ps9A:
undetectable
1c9sK-1ps9A:
undetectable
1c9sA-1ps9A:
8.10
1c9sK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 1c9sA-1ps9A:
undetectable
1c9sB-1ps9A:
undetectable
1c9sA-1ps9A:
8.10
1c9sB-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.41A 1c9sC-1ps9A:
undetectable
1c9sD-1ps9A:
undetectable
1c9sC-1ps9A:
8.10
1c9sD-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 1c9sD-1ps9A:
undetectable
1c9sE-1ps9A:
undetectable
1c9sD-1ps9A:
8.10
1c9sE-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 1c9sE-1ps9A:
0.0
1c9sF-1ps9A:
undetectable
1c9sE-1ps9A:
8.10
1c9sF-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 1c9sF-1ps9A:
undetectable
1c9sG-1ps9A:
undetectable
1c9sF-1ps9A:
8.10
1c9sG-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 1c9sG-1ps9A:
undetectable
1c9sH-1ps9A:
undetectable
1c9sG-1ps9A:
8.10
1c9sH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 1c9sH-1ps9A:
undetectable
1c9sI-1ps9A:
undetectable
1c9sH-1ps9A:
8.10
1c9sI-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 1c9sJ-1ps9A:
undetectable
1c9sK-1ps9A:
undetectable
1c9sJ-1ps9A:
8.10
1c9sK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 1c9sL-1ps9A:
undetectable
1c9sM-1ps9A:
undetectable
1c9sL-1ps9A:
8.10
1c9sM-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 1c9sM-1ps9A:
undetectable
1c9sN-1ps9A:
undetectable
1c9sM-1ps9A:
8.10
1c9sN-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 1c9sO-1ps9A:
undetectable
1c9sP-1ps9A:
undetectable
1c9sO-1ps9A:
8.10
1c9sP-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 1c9sS-1ps9A:
undetectable
1c9sT-1ps9A:
undetectable
1c9sS-1ps9A:
8.10
1c9sT-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
None
0.83A 1eqhA-1ps9A:
undetectable
1eqhA-1ps9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
None
0.86A 1eqhB-1ps9A:
undetectable
1eqhB-1ps9A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 1gtfA-1ps9A:
undetectable
1gtfK-1ps9A:
undetectable
1gtfA-1ps9A:
8.10
1gtfK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 1gtfA-1ps9A:
undetectable
1gtfB-1ps9A:
undetectable
1gtfA-1ps9A:
8.10
1gtfB-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 1gtfB-1ps9A:
undetectable
1gtfC-1ps9A:
undetectable
1gtfB-1ps9A:
8.10
1gtfC-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 1gtfC-1ps9A:
undetectable
1gtfD-1ps9A:
undetectable
1gtfC-1ps9A:
8.10
1gtfD-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 1gtfE-1ps9A:
undetectable
1gtfF-1ps9A:
undetectable
1gtfE-1ps9A:
8.10
1gtfF-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.41A 1gtfF-1ps9A:
undetectable
1gtfG-1ps9A:
undetectable
1gtfF-1ps9A:
8.10
1gtfG-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 1gtfG-1ps9A:
undetectable
1gtfH-1ps9A:
undetectable
1gtfG-1ps9A:
8.10
1gtfH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 1gtfH-1ps9A:
undetectable
1gtfI-1ps9A:
undetectable
1gtfH-1ps9A:
8.10
1gtfI-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.41A 1gtfI-1ps9A:
undetectable
1gtfJ-1ps9A:
undetectable
1gtfI-1ps9A:
8.10
1gtfJ-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 1gtfO-1ps9A:
undetectable
1gtfP-1ps9A:
undetectable
1gtfO-1ps9A:
8.10
1gtfP-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.36A 1gtfP-1ps9A:
undetectable
1gtfQ-1ps9A:
undetectable
1gtfP-1ps9A:
8.10
1gtfQ-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.36A 1gtfT-1ps9A:
undetectable
1gtfU-1ps9A:
undetectable
1gtfT-1ps9A:
8.10
1gtfU-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 11 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.36A 1gtfU-1ps9A:
undetectable
1gtfV-1ps9A:
undetectable
1gtfU-1ps9A:
8.10
1gtfV-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 1gtfL-1ps9A:
undetectable
1gtfV-1ps9A:
undetectable
1gtfL-1ps9A:
8.10
1gtfV-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 8 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.41A 1gtnA-1ps9A:
undetectable
1gtnB-1ps9A:
undetectable
1gtnA-1ps9A:
8.10
1gtnB-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 6 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.43A 1gtnD-1ps9A:
undetectable
1gtnE-1ps9A:
undetectable
1gtnD-1ps9A:
8.10
1gtnE-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 1gtnG-1ps9A:
undetectable
1gtnH-1ps9A:
undetectable
1gtnG-1ps9A:
8.10
1gtnH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.34A 1gtnN-1ps9A:
undetectable
1gtnO-1ps9A:
undetectable
1gtnN-1ps9A:
8.10
1gtnO-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 8 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 1gtnP-1ps9A:
undetectable
1gtnQ-1ps9A:
undetectable
1gtnP-1ps9A:
8.10
1gtnQ-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 1gtnR-1ps9A:
undetectable
1gtnS-1ps9A:
undetectable
1gtnR-1ps9A:
8.10
1gtnS-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_S_TRPS81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.40A 1gtnS-1ps9A:
undetectable
1gtnT-1ps9A:
undetectable
1gtnS-1ps9A:
8.10
1gtnT-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 VAL A 621
ILE A 499
ILE A 505
VAL A 486
LEU A 487
None
None
NAP  A 703 (-3.4A)
None
FAD  A 701 (-4.7A)
0.96A 1qhsA-1ps9A:
2.2
1qhsA-1ps9A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_A_TRPA81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.40A 1utdA-1ps9A:
undetectable
1utdB-1ps9A:
undetectable
1utdA-1ps9A:
8.10
1utdB-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 8 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.41A 1utdB-1ps9A:
undetectable
1utdC-1ps9A:
undetectable
1utdB-1ps9A:
8.10
1utdC-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_C_TRPC81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 1utdC-1ps9A:
undetectable
1utdD-1ps9A:
undetectable
1utdC-1ps9A:
8.10
1utdD-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.41A 1utdD-1ps9A:
undetectable
1utdE-1ps9A:
undetectable
1utdD-1ps9A:
8.10
1utdE-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 8 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.41A 1utdF-1ps9A:
undetectable
1utdG-1ps9A:
undetectable
1utdF-1ps9A:
8.10
1utdG-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.40A 1utdG-1ps9A:
undetectable
1utdH-1ps9A:
undetectable
1utdG-1ps9A:
8.10
1utdH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 8 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 1utdJ-1ps9A:
undetectable
1utdK-1ps9A:
undetectable
1utdJ-1ps9A:
8.10
1utdK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_K_TRPK81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.43A 1utdA-1ps9A:
undetectable
1utdK-1ps9A:
undetectable
1utdA-1ps9A:
8.10
1utdK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_N_TRPN81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 1utdN-1ps9A:
undetectable
1utdO-1ps9A:
undetectable
1utdN-1ps9A:
8.10
1utdO-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_Q_TRPQ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.34A 1utdQ-1ps9A:
undetectable
1utdR-1ps9A:
undetectable
1utdQ-1ps9A:
8.10
1utdR-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_R_TRPR81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 1utdR-1ps9A:
undetectable
1utdS-1ps9A:
undetectable
1utdR-1ps9A:
8.10
1utdS-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 8 ALA A 387
PHE A 388
ALA A 392
LEU A 376
None
0.57A 2bxmA-1ps9A:
0.0
2bxmA-1ps9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 ILE A 533
LEU A 543
GLY A 250
SER A 163
ILE A 249
None
1.26A 2e7fA-1ps9A:
9.1
2e7fA-1ps9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 ILE A 533
LEU A 543
GLY A 250
SER A 163
ILE A 249
None
1.25A 2e7fB-1ps9A:
9.1
2e7fB-1ps9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 GLY A 385
GLY A 664
GLY A 409
ILE A 460
ALA A 462
None
0.90A 2fk8A-1ps9A:
undetectable
2fk8A-1ps9A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 8 TYR A 109
GLU A  31
HIS A  26
GLY A  28
None
None
MDE  A 704 ( 4.1A)
None
0.83A 2ha4A-1ps9A:
undetectable
2ha4A-1ps9A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 7 TYR A 109
GLU A  31
HIS A  26
GLY A  28
None
None
MDE  A 704 ( 4.1A)
None
0.84A 2ha4B-1ps9A:
undetectable
2ha4B-1ps9A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 7 THR A 176
ALA A 194
TYR A 213
LEU A 233
None
0.87A 2hzqA-1ps9A:
undetectable
2hzqA-1ps9A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 ILE A 533
LEU A 543
GLY A 250
SER A 163
ILE A 249
None
1.28A 2ogyA-1ps9A:
9.0
2ogyA-1ps9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 ILE A 533
LEU A 543
GLY A 250
SER A 163
ILE A 249
None
1.28A 2ogyB-1ps9A:
9.0
2ogyB-1ps9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 8 LEU A  99
ARG A 145
VAL A  66
GLY A  65
None
CL  A 706 ( 4.0A)
None
None
0.89A 2qd5B-1ps9A:
undetectable
2qd5B-1ps9A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 9 PHE A 227
ALA A 228
VAL A 231
GLU A 232
None
0.54A 2vufA-1ps9A:
undetectable
2vufA-1ps9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 ILE A 533
LEU A 543
GLY A 250
SER A 163
ILE A 249
None
1.29A 2ycjA-1ps9A:
6.4
2ycjA-1ps9A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 8 LEU A 319
PHE A 313
VAL A 307
ALA A 310
None
None
None
FMN  A 702 (-3.5A)
0.99A 3ax9A-1ps9A:
undetectable
3ax9A-1ps9A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 LEU A 139
ILE A 140
VAL A 160
ILE A 237
PHE A 193
None
0.86A 3b2rA-1ps9A:
undetectable
3b2rA-1ps9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 11 LEU A 139
ILE A 140
VAL A 160
ILE A 237
PHE A 193
None
0.90A 3b2rB-1ps9A:
undetectable
3b2rB-1ps9A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 GLY A 541
ASP A 534
ASP A 219
GLY A 248
THR A 230
None
1.14A 3eeyJ-1ps9A:
undetectable
3eeyJ-1ps9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 7 VAL A  55
MET A 306
ILE A 244
ILE A 210
None
1.05A 3hgxA-1ps9A:
undetectable
3hgxA-1ps9A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 GLY A 382
ALA A 381
VAL A 399
ALA A 387
ILE A 435
FAD  A 701 (-3.5A)
None
None
None
None
0.78A 3n3iA-1ps9A:
undetectable
3n3iA-1ps9A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
None
0.88A 3n8wA-1ps9A:
undetectable
3n8wA-1ps9A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
None
0.88A 3n8zA-1ps9A:
undetectable
3n8zA-1ps9A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 ILE A 237
ILE A 245
VAL A 198
ILE A 212
ILE A 211
None
1.00A 3p4wB-1ps9A:
0.0
3p4wB-1ps9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 ILE A 237
ILE A 245
VAL A 198
ILE A 212
ILE A 211
None
1.00A 3p4wD-1ps9A:
0.0
3p4wD-1ps9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 ILE A 237
ILE A 245
VAL A 198
ILE A 212
ILE A 211
None
1.00A 3p4wE-1ps9A:
0.0
3p4wE-1ps9A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
None
0.84A 3pghC-1ps9A:
undetectable
3pghC-1ps9A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 5 GLU A  31
LEU A  29
HIS A  82
GLY A  35
None
1.24A 3pp1A-1ps9A:
0.0
3pp1A-1ps9A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 5 SER A 163
GLY A  57
GLU A  31
GLU A  30
None
FMN  A 702 ( 4.0A)
None
None
1.22A 3raeB-1ps9A:
0.0
3raeD-1ps9A:
1.2
3raeB-1ps9A:
21.72
3raeD-1ps9A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 8 VAL A 284
TYR A 213
ILE A 212
GLN A 100
None
None
None
FMN  A 702 (-2.8A)
1.00A 3remB-1ps9A:
undetectable
3remB-1ps9A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 7 LEU A 513
VAL A 497
VAL A 486
LEU A 615
None
0.86A 3rgfA-1ps9A:
undetectable
3rgfA-1ps9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
None
0.84A 3rr3A-1ps9A:
undetectable
3rr3A-1ps9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
None
0.85A 3rr3B-1ps9A:
undetectable
3rr3B-1ps9A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 GLY A 225
GLY A 541
LEU A 543
ASN A 169
LEU A 172
None
0.93A 3vywB-1ps9A:
undetectable
3vywB-1ps9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
3 / 3 TYR A   2
ASP A 291
ASP A 316
None
0.88A 4a6eA-1ps9A:
2.8
4a6eA-1ps9A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 7 LEU A 299
ALA A 304
SER A 269
THR A 272
None
1.16A 4iklA-1ps9A:
undetectable
4iklB-1ps9A:
undetectable
4iklA-1ps9A:
10.58
4iklB-1ps9A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 ALA A 657
GLY A 410
ILE A 414
THR A 427
ILE A 335
FAD  A 701 (-3.1A)
FAD  A 701 (-2.9A)
FAD  A 701 (-3.9A)
None
SF4  A 700 (-4.8A)
1.14A 4nptA-1ps9A:
0.0
4nptA-1ps9A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
None
0.79A 4ph9A-1ps9A:
undetectable
4ph9A-1ps9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 VAL A 558
VAL A 606
LEU A 615
GLY A 593
LEU A 560
None
0.78A 4ph9B-1ps9A:
undetectable
4ph9B-1ps9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 8 PRO A 116
LEU A 167
VAL A 197
LEU A 139
None
1.02A 4pwdA-1ps9A:
undetectable
4pwdA-1ps9A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
6 / 12 GLY A 385
GLY A 380
LEU A 461
ILE A 408
ILE A 460
ALA A 389
None
FAD  A 701 (-2.9A)
None
None
None
None
1.27A 4qtuB-1ps9A:
undetectable
4qtuB-1ps9A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 GLY A 385
GLY A 380
ILE A 408
ILE A 460
ALA A 389
None
FAD  A 701 (-2.9A)
None
None
None
1.07A 4qtuD-1ps9A:
undetectable
4qtuD-1ps9A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 5 GLY A 248
ARG A 214
GLY A 162
GLU A 159
None
FMN  A 702 (-2.5A)
None
None
1.11A 4z2eB-1ps9A:
undetectable
4z2eC-1ps9A:
undetectable
4z2eB-1ps9A:
21.58
4z2eC-1ps9A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 7 LEU A 220
GLU A 222
GLY A 541
GLY A 542
None
0.75A 5a06A-1ps9A:
undetectable
5a06A-1ps9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 7 LEU A 220
GLU A 222
GLY A 541
GLY A 542
None
0.76A 5a06C-1ps9A:
2.0
5a06C-1ps9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 7 LEU A 220
GLU A 222
GLY A 541
GLY A 542
None
0.75A 5a06E-1ps9A:
undetectable
5a06E-1ps9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 7 LEU A 220
GLU A 222
GLY A 541
GLY A 542
None
0.75A 5a06F-1ps9A:
2.8
5a06F-1ps9A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 ALA A 510
GLY A 501
GLY A 506
GLY A 504
LEU A 560
None
NAP  A 703 ( 3.9A)
None
NAP  A 703 (-3.5A)
None
1.06A 5c0oH-1ps9A:
5.1
5c0oH-1ps9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.42A 5eeuA-1ps9A:
undetectable
5eeuB-1ps9A:
undetectable
5eeuA-1ps9A:
8.10
5eeuB-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eeuB-1ps9A:
undetectable
5eeuC-1ps9A:
undetectable
5eeuB-1ps9A:
8.10
5eeuC-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eeuC-1ps9A:
undetectable
5eeuD-1ps9A:
undetectable
5eeuC-1ps9A:
8.10
5eeuD-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eeuD-1ps9A:
undetectable
5eeuE-1ps9A:
undetectable
5eeuD-1ps9A:
8.10
5eeuE-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eeuE-1ps9A:
undetectable
5eeuF-1ps9A:
undetectable
5eeuE-1ps9A:
8.10
5eeuF-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5eeuG-1ps9A:
undetectable
5eeuH-1ps9A:
undetectable
5eeuG-1ps9A:
8.10
5eeuH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eeuH-1ps9A:
undetectable
5eeuI-1ps9A:
undetectable
5eeuH-1ps9A:
8.10
5eeuI-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eeuJ-1ps9A:
undetectable
5eeuK-1ps9A:
undetectable
5eeuJ-1ps9A:
8.10
5eeuK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.40A 5eeuA-1ps9A:
undetectable
5eeuK-1ps9A:
undetectable
5eeuA-1ps9A:
8.10
5eeuK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eeuN-1ps9A:
undetectable
5eeuO-1ps9A:
undetectable
5eeuN-1ps9A:
8.10
5eeuO-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5eeuP-1ps9A:
undetectable
5eeuQ-1ps9A:
undetectable
5eeuP-1ps9A:
8.10
5eeuQ-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eeuR-1ps9A:
undetectable
5eeuS-1ps9A:
undetectable
5eeuR-1ps9A:
8.10
5eeuS-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5eeuS-1ps9A:
undetectable
5eeuT-1ps9A:
undetectable
5eeuS-1ps9A:
8.10
5eeuT-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eeuT-1ps9A:
undetectable
5eeuU-1ps9A:
undetectable
5eeuT-1ps9A:
8.10
5eeuU-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5eeuU-1ps9A:
undetectable
5eeuV-1ps9A:
undetectable
5eeuU-1ps9A:
8.10
5eeuV-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eevB-1ps9A:
undetectable
5eevC-1ps9A:
undetectable
5eevB-1ps9A:
8.10
5eevC-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eevC-1ps9A:
undetectable
5eevD-1ps9A:
undetectable
5eevC-1ps9A:
8.10
5eevD-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eevD-1ps9A:
undetectable
5eevE-1ps9A:
0.0
5eevD-1ps9A:
8.10
5eevE-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eevE-1ps9A:
0.0
5eevF-1ps9A:
undetectable
5eevE-1ps9A:
8.10
5eevF-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5eevG-1ps9A:
undetectable
5eevH-1ps9A:
undetectable
5eevG-1ps9A:
8.10
5eevH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eevH-1ps9A:
undetectable
5eevI-1ps9A:
undetectable
5eevH-1ps9A:
8.10
5eevI-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eevJ-1ps9A:
undetectable
5eevK-1ps9A:
undetectable
5eevJ-1ps9A:
8.10
5eevK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 5eevA-1ps9A:
undetectable
5eevK-1ps9A:
undetectable
5eevA-1ps9A:
8.10
5eevK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eevN-1ps9A:
undetectable
5eevO-1ps9A:
undetectable
5eevN-1ps9A:
8.10
5eevO-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eevP-1ps9A:
undetectable
5eevQ-1ps9A:
undetectable
5eevP-1ps9A:
8.10
5eevQ-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eevR-1ps9A:
undetectable
5eevS-1ps9A:
undetectable
5eevR-1ps9A:
8.10
5eevS-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eevS-1ps9A:
undetectable
5eevT-1ps9A:
undetectable
5eevS-1ps9A:
8.10
5eevT-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eevT-1ps9A:
undetectable
5eevU-1ps9A:
undetectable
5eevT-1ps9A:
8.10
5eevU-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5eevU-1ps9A:
undetectable
5eevV-1ps9A:
undetectable
5eevU-1ps9A:
8.10
5eevV-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eewB-1ps9A:
undetectable
5eewC-1ps9A:
undetectable
5eewB-1ps9A:
8.10
5eewC-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eewC-1ps9A:
undetectable
5eewD-1ps9A:
undetectable
5eewC-1ps9A:
8.10
5eewD-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eewD-1ps9A:
undetectable
5eewE-1ps9A:
undetectable
5eewD-1ps9A:
8.10
5eewE-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eewE-1ps9A:
undetectable
5eewF-1ps9A:
undetectable
5eewE-1ps9A:
8.10
5eewF-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5eewG-1ps9A:
undetectable
5eewH-1ps9A:
undetectable
5eewG-1ps9A:
8.10
5eewH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eewH-1ps9A:
undetectable
5eewI-1ps9A:
undetectable
5eewH-1ps9A:
8.10
5eewI-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eewJ-1ps9A:
undetectable
5eewK-1ps9A:
undetectable
5eewJ-1ps9A:
8.10
5eewK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 5eewA-1ps9A:
undetectable
5eewK-1ps9A:
undetectable
5eewA-1ps9A:
8.10
5eewK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eewN-1ps9A:
undetectable
5eewO-1ps9A:
undetectable
5eewN-1ps9A:
8.10
5eewO-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eewP-1ps9A:
undetectable
5eewQ-1ps9A:
undetectable
5eewP-1ps9A:
8.10
5eewQ-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eewR-1ps9A:
undetectable
5eewS-1ps9A:
undetectable
5eewR-1ps9A:
8.10
5eewS-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eewS-1ps9A:
undetectable
5eewT-1ps9A:
undetectable
5eewS-1ps9A:
8.10
5eewT-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eewT-1ps9A:
undetectable
5eewU-1ps9A:
undetectable
5eewT-1ps9A:
8.10
5eewU-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5eewU-1ps9A:
undetectable
5eewV-1ps9A:
undetectable
5eewU-1ps9A:
8.10
5eewV-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eexB-1ps9A:
undetectable
5eexC-1ps9A:
undetectable
5eexB-1ps9A:
8.10
5eexC-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eexC-1ps9A:
undetectable
5eexD-1ps9A:
undetectable
5eexC-1ps9A:
8.10
5eexD-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eexD-1ps9A:
undetectable
5eexE-1ps9A:
undetectable
5eexD-1ps9A:
8.10
5eexE-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eexE-1ps9A:
undetectable
5eexF-1ps9A:
undetectable
5eexE-1ps9A:
8.10
5eexF-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5eexG-1ps9A:
undetectable
5eexH-1ps9A:
undetectable
5eexG-1ps9A:
8.10
5eexH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eexH-1ps9A:
undetectable
5eexI-1ps9A:
undetectable
5eexH-1ps9A:
8.10
5eexI-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eexJ-1ps9A:
undetectable
5eexK-1ps9A:
undetectable
5eexJ-1ps9A:
8.10
5eexK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 5eexA-1ps9A:
undetectable
5eexK-1ps9A:
undetectable
5eexA-1ps9A:
8.10
5eexK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eexN-1ps9A:
undetectable
5eexO-1ps9A:
undetectable
5eexN-1ps9A:
8.10
5eexO-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eexP-1ps9A:
undetectable
5eexQ-1ps9A:
undetectable
5eexP-1ps9A:
8.10
5eexQ-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5eexQ-1ps9A:
undetectable
5eexR-1ps9A:
undetectable
5eexQ-1ps9A:
8.10
5eexR-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eexR-1ps9A:
undetectable
5eexS-1ps9A:
undetectable
5eexR-1ps9A:
8.10
5eexS-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eexS-1ps9A:
undetectable
5eexT-1ps9A:
undetectable
5eexS-1ps9A:
8.10
5eexT-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eexT-1ps9A:
undetectable
5eexU-1ps9A:
undetectable
5eexT-1ps9A:
8.10
5eexU-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5eexU-1ps9A:
undetectable
5eexV-1ps9A:
undetectable
5eexU-1ps9A:
8.10
5eexV-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5eeyB-1ps9A:
undetectable
5eeyC-1ps9A:
undetectable
5eeyB-1ps9A:
8.10
5eeyC-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eeyC-1ps9A:
undetectable
5eeyD-1ps9A:
undetectable
5eeyC-1ps9A:
8.10
5eeyD-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eeyD-1ps9A:
undetectable
5eeyE-1ps9A:
0.0
5eeyD-1ps9A:
8.10
5eeyE-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eeyE-1ps9A:
0.0
5eeyF-1ps9A:
undetectable
5eeyE-1ps9A:
8.10
5eeyF-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5eeyG-1ps9A:
undetectable
5eeyH-1ps9A:
undetectable
5eeyG-1ps9A:
8.10
5eeyH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eeyH-1ps9A:
undetectable
5eeyI-1ps9A:
undetectable
5eeyH-1ps9A:
8.10
5eeyI-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eeyJ-1ps9A:
undetectable
5eeyK-1ps9A:
undetectable
5eeyJ-1ps9A:
8.10
5eeyK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 5eeyA-1ps9A:
undetectable
5eeyK-1ps9A:
undetectable
5eeyA-1ps9A:
8.10
5eeyK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eeyN-1ps9A:
undetectable
5eeyO-1ps9A:
undetectable
5eeyN-1ps9A:
8.10
5eeyO-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eeyP-1ps9A:
undetectable
5eeyQ-1ps9A:
undetectable
5eeyP-1ps9A:
8.10
5eeyQ-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eeyQ-1ps9A:
undetectable
5eeyR-1ps9A:
undetectable
5eeyQ-1ps9A:
8.10
5eeyR-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eeyR-1ps9A:
undetectable
5eeyS-1ps9A:
undetectable
5eeyR-1ps9A:
8.10
5eeyS-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eeyS-1ps9A:
undetectable
5eeyT-1ps9A:
undetectable
5eeyS-1ps9A:
8.10
5eeyT-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eeyT-1ps9A:
undetectable
5eeyU-1ps9A:
undetectable
5eeyT-1ps9A:
8.10
5eeyU-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5eeyU-1ps9A:
undetectable
5eeyV-1ps9A:
undetectable
5eeyU-1ps9A:
8.10
5eeyV-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5eezB-1ps9A:
undetectable
5eezC-1ps9A:
undetectable
5eezB-1ps9A:
8.10
5eezC-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5eezC-1ps9A:
undetectable
5eezD-1ps9A:
undetectable
5eezC-1ps9A:
8.10
5eezD-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eezD-1ps9A:
undetectable
5eezE-1ps9A:
0.0
5eezD-1ps9A:
8.10
5eezE-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5eezE-1ps9A:
0.0
5eezF-1ps9A:
undetectable
5eezE-1ps9A:
8.10
5eezF-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5eezG-1ps9A:
undetectable
5eezH-1ps9A:
undetectable
5eezG-1ps9A:
8.10
5eezH-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5eezH-1ps9A:
undetectable
5eezI-1ps9A:
undetectable
5eezH-1ps9A:
8.10
5eezI-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5eezJ-1ps9A:
undetectable
5eezK-1ps9A:
undetectable
5eezJ-1ps9A:
8.10
5eezK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 5eezA-1ps9A:
undetectable
5eezK-1ps9A:
undetectable
5eezA-1ps9A:
8.10
5eezK-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eezN-1ps9A:
undetectable
5eezO-1ps9A:
undetectable
5eezN-1ps9A:
8.10
5eezO-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eezP-1ps9A:
undetectable
5eezQ-1ps9A:
undetectable
5eezP-1ps9A:
8.10
5eezQ-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eezQ-1ps9A:
undetectable
5eezR-1ps9A:
undetectable
5eezQ-1ps9A:
8.10
5eezR-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.36A 5eezR-1ps9A:
undetectable
5eezS-1ps9A:
undetectable
5eezR-1ps9A:
8.10
5eezS-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eezS-1ps9A:
undetectable
5eezT-1ps9A:
undetectable
5eezS-1ps9A:
8.10
5eezT-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5eezT-1ps9A:
undetectable
5eezU-1ps9A:
undetectable
5eezT-1ps9A:
8.10
5eezU-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5eezU-1ps9A:
undetectable
5eezV-1ps9A:
undetectable
5eezU-1ps9A:
8.10
5eezV-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5ef0B-1ps9A:
undetectable
5ef0C-1ps9A:
undetectable
5ef0B-1ps9A:
8.10
5ef0C-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5ef0C-1ps9A:
undetectable
5ef0D-1ps9A:
undetectable
5ef0C-1ps9A:
8.10
5ef0D-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5ef0D-1ps9A:
undetectable
5ef0E-1ps9A:
0.0
5ef0D-1ps9A:
8.10
5ef0E-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5ef0E-1ps9A:
0.0
5ef0F-1ps9A:
undetectable
5ef0E-1ps9A:
8.10
5ef0F-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.36A 5ef0G-1ps9A:
undetectable
5ef0H-1ps9A:
undetectable
5ef0G-1ps9A:
8.10
5ef0H-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5ef0H-1ps9A:
undetectable
5ef0I-1ps9A:
undetectable
5ef0H-1ps9A:
8.10
5ef0I-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5ef0J-1ps9A:
undetectable
5ef0K-1ps9A:
undetectable
5ef0J-1ps9A:
8.10
5ef0K-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 5ef0A-1ps9A:
undetectable
5ef0K-1ps9A:
undetectable
5ef0A-1ps9A:
8.10
5ef0K-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef0N-1ps9A:
undetectable
5ef0O-1ps9A:
undetectable
5ef0N-1ps9A:
8.10
5ef0O-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef0P-1ps9A:
undetectable
5ef0Q-1ps9A:
undetectable
5ef0P-1ps9A:
8.10
5ef0Q-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef0Q-1ps9A:
undetectable
5ef0R-1ps9A:
undetectable
5ef0Q-1ps9A:
8.10
5ef0R-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef0R-1ps9A:
undetectable
5ef0S-1ps9A:
undetectable
5ef0R-1ps9A:
8.10
5ef0S-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef0S-1ps9A:
undetectable
5ef0T-1ps9A:
undetectable
5ef0S-1ps9A:
8.10
5ef0T-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef0T-1ps9A:
undetectable
5ef0U-1ps9A:
undetectable
5ef0T-1ps9A:
8.10
5ef0U-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5ef0U-1ps9A:
undetectable
5ef0V-1ps9A:
undetectable
5ef0U-1ps9A:
8.10
5ef0V-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5ef1B-1ps9A:
undetectable
5ef1C-1ps9A:
undetectable
5ef1B-1ps9A:
8.10
5ef1C-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5ef1C-1ps9A:
undetectable
5ef1D-1ps9A:
undetectable
5ef1C-1ps9A:
8.10
5ef1D-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5ef1D-1ps9A:
undetectable
5ef1E-1ps9A:
undetectable
5ef1D-1ps9A:
8.10
5ef1E-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5ef1E-1ps9A:
undetectable
5ef1F-1ps9A:
undetectable
5ef1E-1ps9A:
8.10
5ef1F-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.36A 5ef1G-1ps9A:
undetectable
5ef1H-1ps9A:
undetectable
5ef1G-1ps9A:
8.10
5ef1H-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5ef1H-1ps9A:
undetectable
5ef1I-1ps9A:
undetectable
5ef1H-1ps9A:
8.10
5ef1I-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5ef1J-1ps9A:
undetectable
5ef1K-1ps9A:
undetectable
5ef1J-1ps9A:
8.10
5ef1K-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 5ef1A-1ps9A:
undetectable
5ef1K-1ps9A:
undetectable
5ef1A-1ps9A:
8.10
5ef1K-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef1N-1ps9A:
undetectable
5ef1O-1ps9A:
undetectable
5ef1N-1ps9A:
8.10
5ef1O-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef1P-1ps9A:
undetectable
5ef1Q-1ps9A:
undetectable
5ef1P-1ps9A:
8.10
5ef1Q-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef1Q-1ps9A:
undetectable
5ef1R-1ps9A:
undetectable
5ef1Q-1ps9A:
8.10
5ef1R-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.36A 5ef1R-1ps9A:
undetectable
5ef1S-1ps9A:
undetectable
5ef1R-1ps9A:
8.10
5ef1S-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef1S-1ps9A:
undetectable
5ef1T-1ps9A:
undetectable
5ef1S-1ps9A:
8.10
5ef1T-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef1T-1ps9A:
undetectable
5ef1U-1ps9A:
undetectable
5ef1T-1ps9A:
8.10
5ef1U-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5ef1U-1ps9A:
undetectable
5ef1V-1ps9A:
undetectable
5ef1U-1ps9A:
8.10
5ef1V-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5ef2B-1ps9A:
undetectable
5ef2C-1ps9A:
undetectable
5ef2B-1ps9A:
8.10
5ef2C-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5ef2C-1ps9A:
undetectable
5ef2D-1ps9A:
undetectable
5ef2C-1ps9A:
8.10
5ef2D-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5ef2D-1ps9A:
undetectable
5ef2E-1ps9A:
undetectable
5ef2D-1ps9A:
8.10
5ef2E-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5ef2E-1ps9A:
undetectable
5ef2F-1ps9A:
undetectable
5ef2E-1ps9A:
8.10
5ef2F-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.36A 5ef2G-1ps9A:
undetectable
5ef2H-1ps9A:
undetectable
5ef2G-1ps9A:
8.10
5ef2H-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5ef2H-1ps9A:
undetectable
5ef2I-1ps9A:
undetectable
5ef2H-1ps9A:
8.10
5ef2I-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5ef2J-1ps9A:
undetectable
5ef2K-1ps9A:
undetectable
5ef2J-1ps9A:
8.10
5ef2K-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 5ef2A-1ps9A:
undetectable
5ef2K-1ps9A:
undetectable
5ef2A-1ps9A:
8.10
5ef2K-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef2N-1ps9A:
undetectable
5ef2O-1ps9A:
undetectable
5ef2N-1ps9A:
8.10
5ef2O-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef2P-1ps9A:
undetectable
5ef2Q-1ps9A:
undetectable
5ef2P-1ps9A:
8.10
5ef2Q-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef2Q-1ps9A:
undetectable
5ef2R-1ps9A:
undetectable
5ef2Q-1ps9A:
8.10
5ef2R-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.36A 5ef2R-1ps9A:
undetectable
5ef2S-1ps9A:
undetectable
5ef2R-1ps9A:
8.10
5ef2S-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef2S-1ps9A:
undetectable
5ef2T-1ps9A:
undetectable
5ef2S-1ps9A:
8.10
5ef2T-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef2T-1ps9A:
undetectable
5ef2U-1ps9A:
undetectable
5ef2T-1ps9A:
8.10
5ef2U-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5ef2U-1ps9A:
undetectable
5ef2V-1ps9A:
undetectable
5ef2U-1ps9A:
8.10
5ef2V-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5ef3B-1ps9A:
undetectable
5ef3C-1ps9A:
undetectable
5ef3B-1ps9A:
8.10
5ef3C-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_C_TRPC101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5ef3C-1ps9A:
undetectable
5ef3D-1ps9A:
undetectable
5ef3C-1ps9A:
8.10
5ef3D-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.40A 5ef3D-1ps9A:
undetectable
5ef3E-1ps9A:
undetectable
5ef3D-1ps9A:
8.10
5ef3E-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_E_TRPE101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.37A 5ef3E-1ps9A:
undetectable
5ef3F-1ps9A:
undetectable
5ef3E-1ps9A:
8.10
5ef3F-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_G_TRPG101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.36A 5ef3G-1ps9A:
undetectable
5ef3H-1ps9A:
undetectable
5ef3G-1ps9A:
8.10
5ef3H-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.39A 5ef3H-1ps9A:
undetectable
5ef3I-1ps9A:
undetectable
5ef3H-1ps9A:
8.10
5ef3I-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 THR A 230
GLY A 248
THR A 272
THR A 247
ILE A 249
None
1.38A 5ef3J-1ps9A:
undetectable
5ef3K-1ps9A:
undetectable
5ef3J-1ps9A:
8.10
5ef3K-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_K_TRPK101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.39A 5ef3A-1ps9A:
undetectable
5ef3K-1ps9A:
undetectable
5ef3A-1ps9A:
8.10
5ef3K-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_O_TRPO101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef3N-1ps9A:
undetectable
5ef3O-1ps9A:
undetectable
5ef3N-1ps9A:
8.10
5ef3O-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_Q_TRPQ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef3P-1ps9A:
undetectable
5ef3Q-1ps9A:
undetectable
5ef3P-1ps9A:
8.10
5ef3Q-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef3Q-1ps9A:
undetectable
5ef3R-1ps9A:
undetectable
5ef3Q-1ps9A:
8.10
5ef3R-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.36A 5ef3R-1ps9A:
undetectable
5ef3S-1ps9A:
undetectable
5ef3R-1ps9A:
8.10
5ef3S-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_T_TRPT101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef3S-1ps9A:
undetectable
5ef3T-1ps9A:
undetectable
5ef3S-1ps9A:
8.10
5ef3T-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.37A 5ef3T-1ps9A:
undetectable
5ef3U-1ps9A:
undetectable
5ef3T-1ps9A:
8.10
5ef3U-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_V_TRPV101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 10 GLY A 248
THR A 272
THR A 247
ILE A 249
THR A 230
None
1.38A 5ef3U-1ps9A:
undetectable
5ef3V-1ps9A:
undetectable
5ef3U-1ps9A:
8.10
5ef3V-1ps9A:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 ALA A 415
PHE A 268
ILE A 249
PHE A 527
HIS A 579
FAD  A 701 (-3.6A)
None
None
None
None
1.07A 5fsaA-1ps9A:
undetectable
5fsaA-1ps9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 PRO A  61
VAL A 160
ALA A 194
VAL A 197
THR A 173
None
1.07A 5igpA-1ps9A:
undetectable
5igpA-1ps9A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 ALA A 415
PHE A 268
ILE A 249
PHE A 527
HIS A 579
FAD  A 701 (-3.6A)
None
None
None
None
1.16A 5jlcA-1ps9A:
undetectable
5jlcA-1ps9A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 8 LEU A 537
LEU A 275
ILE A 289
THR A 285
None
0.93A 5ljbA-1ps9A:
undetectable
5ljbA-1ps9A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
6 / 11 LEU A  74
PRO A  61
GLU A 159
GLY A  58
LEU A 149
ALA A 150
None
None
None
FMN  A 702 (-3.3A)
None
None
1.47A 5o96A-1ps9A:
undetectable
5o96B-1ps9A:
4.1
5o96A-1ps9A:
18.61
5o96B-1ps9A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 7 THR A 173
ARG A 190
PHE A 171
LEU A 167
None
1.23A 5uxcA-1ps9A:
0.4
5uxcA-1ps9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
4 / 4 GLY A 541
LEU A 543
VAL A 221
GLU A 222
None
1.16A 5yw0A-1ps9A:
0.0
5yw0A-1ps9A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 ILE A 460
GLY A 647
ALA A 462
ALA A 660
ALA A 657
None
FAD  A 701 (-3.4A)
None
FAD  A 701 ( 3.9A)
FAD  A 701 (-3.1A)
1.07A 5zw4A-1ps9A:
5.2
5zw4A-1ps9A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 12 ASN A 169
LEU A 172
GLY A 248
ILE A 533
LEU A 220
None
1.08A 6dwnC-1ps9A:
undetectable
6dwnC-1ps9A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli)
5 / 9 SER A 595
ILE A 500
ARG A 562
PRO A 470
ILE A 472
None
None
NAP  A 703 (-3.5A)
NAP  A 703 ( 4.3A)
None
1.28A 6ef6A-1ps9A:
undetectable
6ef6A-1ps9A:
18.96