SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1psz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		3 / 3 SER A 212
GLU A 254
ASP A  65
 None
 0.78A 2zulA-1pszA:
undetectable		 2zulA-1pszA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		3 / 3 SER A 212
GLU A 254
ASP A  65
 None
 0.75A 3dmhA-1pszA:
undetectable		 3dmhA-1pszA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		5 / 9 ALA A  50
LEU A  56
VAL A  35
ILE A  42
PHE A  86
 None
 1.38A 3fl9H-1pszA:
undetectable		 3fl9H-1pszA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		3 / 3 ILE A  41
PHE A 150
HIS A  67
 None
None
ZN  A1000 ( 3.2A)
 0.66A 3h0aA-1pszA:
undetectable		 3h0aA-1pszA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		4 / 6 HIS A 139
GLU A 254
ASP A 280
SER A 256
 ZN  A1000 ( 3.2A)
None
ZN  A1000 ( 2.2A)
None
 1.11A 4apjA-1pszA:
undetectable
4apjP-1pszA:
undetectable		 4apjA-1pszA:
19.52
4apjP-1pszA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		5 / 12 GLU A 254
ASP A 280
ASP A 137
GLY A 206
SER A 204
 None
ZN  A1000 ( 2.2A)
None
None
None
 1.21A 4djeB-1pszA:
undetectable		 4djeB-1pszA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		5 / 12 GLU A 254
ASP A 280
LEU A 127
GLY A 206
SER A 204
 None
ZN  A1000 ( 2.2A)
None
None
None
 1.27A 4djfB-1pszA:
undetectable		 4djfB-1pszA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		4 / 7 HIS A  67
PRO A  66
ASP A  65
ASP A 280
 ZN  A1000 ( 3.2A)
None
None
ZN  A1000 ( 2.2A)
 1.30A 4ndnC-1pszA:
undetectable		 4ndnC-1pszA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		4 / 7 HIS A  67
PRO A  66
ASP A  65
ASP A 280
 ZN  A1000 ( 3.2A)
None
None
ZN  A1000 ( 2.2A)
 1.21A 4odjA-1pszA:
undetectable		 4odjA-1pszA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		5 / 8 THR A  38
ILE A 154
VAL A 122
ILE A  90
PHE A  86
 None
 1.44A 4r38D-1pszA:
undetectable		 4r38D-1pszA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		4 / 7 HIS A  67
PRO A  66
ASP A  65
ASP A 280
 ZN  A1000 ( 3.2A)
None
None
ZN  A1000 ( 2.2A)
 1.25A 5a1iA-1pszA:
undetectable		 5a1iA-1pszA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		4 / 6 PHE A 100
ASN A  88
LEU A  92
GLY A  95
 None
 0.90A 5o4yA-1pszA:
undetectable		 5o4yA-1pszA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		4 / 8 HIS A  67
PRO A  66
ASP A  65
ASP A 280
 ZN  A1000 ( 3.2A)
None
None
ZN  A1000 ( 2.2A)
 1.21A 5t8sB-1pszA:
undetectable		 5t8sB-1pszA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		5 / 12 ILE A  42
GLN A 157
LEU A  84
ILE A  59
LEU A  56
 None
 1.05A 6a60D-1pszA:
undetectable		 6a60D-1pszA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		4 / 8 HIS A  67
PRO A  66
ASP A  65
ASP A 280
 ZN  A1000 ( 3.2A)
None
None
ZN  A1000 ( 2.2A)
 1.23A 6fcbA-1pszA:
undetectable		 6fcbA-1pszA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1psz PROTEIN (SURFACE
ANTIGEN PSAA)
(Streptococcus
pneumoniae) 		4 / 7 HIS A  67
PRO A  66
ASP A  65
ASP A 280
 ZN  A1000 ( 3.2A)
None
None
ZN  A1000 ( 2.2A)
 1.24A 6g6rA-1pszA:
undetectable		 6g6rA-1pszA:
21.67