SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ptj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.72A 1c9sI-1ptjA:
undetectable
1c9sJ-1ptjA:
undetectable		 1c9sI-1ptjA:
13.14
1c9sJ-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.70A 1c9sU-1ptjA:
undetectable
1c9sV-1ptjA:
undetectable		 1c9sU-1ptjA:
13.14
1c9sV-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 7 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.71A 1gtnA-1ptjA:
undetectable
1gtnK-1ptjA:
undetectable		 1gtnA-1ptjA:
13.14
1gtnK-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.72A 1gtnA-1ptjA:
undetectable
1gtnB-1ptjA:
undetectable		 1gtnA-1ptjA:
13.14
1gtnB-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.70A 1gtnE-1ptjA:
undetectable
1gtnF-1ptjA:
undetectable		 1gtnE-1ptjA:
13.14
1gtnF-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.72A 1gtnI-1ptjA:
undetectable
1gtnJ-1ptjA:
0.0		 1gtnI-1ptjA:
13.14
1gtnJ-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.71A 1gtnP-1ptjA:
undetectable
1gtnQ-1ptjA:
undetectable		 1gtnP-1ptjA:
13.14
1gtnQ-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 12 THR A 118
PHE A 342
LEU A 343
VAL A 347
PHE A  31
 None
 1.39A 1q23C-1ptjA:
undetectable		 1q23C-1ptjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 12 THR A 118
PHE A 342
LEU A 343
VAL A 347
PHE A  31
 None
 1.45A 1q23D-1ptjA:
undetectable
1q23E-1ptjA:
undetectable		 1q23D-1ptjA:
20.11
1q23E-1ptjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 10 THR A 118
PHE A 342
LEU A 343
VAL A 347
PHE A  31
 None
 1.38A 1q23E-1ptjA:
undetectable		 1q23E-1ptjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 11 THR A 118
PHE A 342
LEU A 343
VAL A 347
PHE A  31
 None
 1.43A 1q23I-1ptjA:
0.0		 1q23I-1ptjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 11 THR A 118
PHE A 342
LEU A 343
VAL A 347
PHE A  31
 None
 1.36A 1q23J-1ptjA:
undetectable		 1q23J-1ptjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 10 THR A 118
PHE A 342
LEU A 343
VAL A 347
PHE A  31
 None
 1.46A 1q23K-1ptjA:
undetectable		 1q23K-1ptjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 11 THR A 118
PHE A 342
LEU A 343
VAL A 347
PHE A  31
 None
 1.41A 1q23L-1ptjA:
undetectable		 1q23L-1ptjA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.71A 1utdB-1ptjA:
undetectable
1utdC-1ptjA:
undetectable		 1utdB-1ptjA:
13.14
1utdC-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.70A 1utdF-1ptjA:
undetectable
1utdG-1ptjA:
undetectable		 1utdF-1ptjA:
13.14
1utdG-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.69A 1utdI-1ptjA:
undetectable
1utdJ-1ptjA:
undetectable		 1utdI-1ptjA:
13.14
1utdJ-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A 184
ALA A 200
THR A 207
ILE A 188
 None
 0.72A 1utdJ-1ptjA:
undetectable
1utdK-1ptjA:
undetectable		 1utdJ-1ptjA:
13.14
1utdK-1ptjA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		3 / 3 GLU A  13
GLU A  86
LEU A 100
 None
 0.71A 1v8bA-1ptjA:
8.4		 1v8bA-1ptjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		3 / 3 GLU A  13
GLU A  86
LEU A 100
 None
 0.73A 1v8bB-1ptjA:
8.3		 1v8bB-1ptjA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 9 ASN A 300
ILE A 276
ILE A 291
ASP A 292
ALA A 261
 None
 1.27A 2dtjA-1ptjA:
undetectable
2dtjB-1ptjA:
undetectable		 2dtjA-1ptjA:
19.69
2dtjB-1ptjA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 11 LEU A 100
LEU A 339
LEU A 112
ILE A   5
VAL A  70
 None
 1.13A 2uxoB-1ptjA:
undetectable		 2uxoB-1ptjA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 ALA A 191
GLY A 152
ILE A 291
THR A 258
 None
 0.83A 3el9A-1ptjA:
undetectable		 3el9A-1ptjA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		3 / 3 VAL A  22
LYS A  25
HIS A 346
 None
 0.95A 3elzA-1ptjA:
undetectable		 3elzA-1ptjA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		3 / 3 ASP A 135
SER A 138
ARG A 127
 SND  A 500 (-3.7A)
SND  A 500 (-3.1A)
SND  A 500 (-3.9A)
 0.97A 3loqA-1ptjA:
4.7		 3loqA-1ptjA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 6 GLU A   8
LYS A  73
LYS A   7
GLU A  36
 None
 1.41A 4a7tF-1ptjA:
undetectable		 4a7tF-1ptjA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 7 LEU A 266
ALA A 183
VAL A 180
ILE A 260
 SND  A 500 (-3.6A)
None
None
None
 0.96A 4eyrA-1ptjA:
undetectable		 4eyrA-1ptjA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 9 ALA A 196
GLY A 152
ILE A 150
ILE A 188
VAL A 198
 None
 1.05A 4nptA-1ptjA:
undetectable		 4nptA-1ptjA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 12 LEU A  50
ALA A  39
ILE A  34
ALA A  64
ILE A   3
 None
 0.95A 4o2bD-1ptjA:
3.9		 4o2bD-1ptjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 12 GLY A 145
GLY A 184
ILE A 291
SER A 141
ALA A 144
 None
None
None
SND  A 500 ( 4.7A)
None
 1.18A 4qtuD-1ptjA:
3.8		 4qtuD-1ptjA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		3 / 3 VAL A 108
LEU A 112
VAL A  87
 None
 0.51A 4wq4A-1ptjA:
undetectable		 4wq4A-1ptjA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		3 / 3 VAL A 310
LEU A 255
MET A 280
 None
 0.84A 5ikrA-1ptjA:
undetectable		 5ikrA-1ptjA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 12 LEU A  50
ALA A  39
ILE A  34
ALA A  64
ILE A   3
 None
 0.84A 5xiwB-1ptjA:
undetectable		 5xiwB-1ptjA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		4 / 8 GLY A  28
LEU A  29
VAL A  33
LEU A 340
 None
 0.78A 6czmD-1ptjA:
undetectable
6czmF-1ptjA:
undetectable		 6czmD-1ptjA:
22.06
6czmF-1ptjA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 1ptj NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1
(Rhodospirillum
rubrum) 		5 / 10 GLY A 298
GLY A 299
ASN A 300
ALA A 272
PRO A 271
 None
 1.06A 6e5zA-1ptjA:
2.4		 6e5zA-1ptjA:
23.80