SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1puj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 LEU A  30
LEU A 136
ILE A  44
LEU A 167
VAL A 163
 None
 1.13A 1hrkA-1pujA:
5.0		 1hrkA-1pujA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		4 / 4 LEU A  56
SER A 100
LEU A  93
LEU A 136
 None
 0.90A 1yajA-1pujA:
1.1		 1yajA-1pujA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		4 / 5 LEU A  56
SER A 100
LEU A  93
LEU A 136
 None
 0.89A 1yajD-1pujA:
undetectable		 1yajD-1pujA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 LEU A  30
LEU A 136
ILE A  44
LEU A 167
VAL A 163
 None
 1.07A 2hrcA-1pujA:
undetectable		 2hrcA-1pujA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 LEU A  30
LEU A 136
ILE A  44
LEU A 167
VAL A 163
 None
 1.09A 2hrcB-1pujA:
4.3		 2hrcB-1pujA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 10 ILE A  85
ILE A  96
LEU A 136
ASN A 138
VAL A 163
 None
 1.18A 2nnhB-1pujA:
0.0		 2nnhB-1pujA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 GLU A 278
TRP A  71
LEU A  57
MET A  55
PHE A  75
 None
 1.48A 2noaA-1pujA:
undetectable		 2noaA-1pujA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 LEU A  30
LEU A 136
ILE A  44
LEU A 167
VAL A 163
 None
 1.15A 2po7A-1pujA:
0.0		 2po7A-1pujA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 LEU A  30
LEU A 136
ILE A  44
LEU A 167
VAL A 163
 None
 1.17A 2po7B-1pujA:
2.2		 2po7B-1pujA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 11 VAL A  31
LEU A  30
GLY A 127
ILE A 175
LYS A  22
 None
 1.02A 3bjwB-1pujA:
undetectable		 3bjwB-1pujA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 VAL A  31
LEU A  30
GLY A 127
ILE A 175
LYS A  22
 None
 1.09A 3bjwF-1pujA:
undetectable		 3bjwF-1pujA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 ILE A 264
VAL A 205
GLY A 209
PHE A 212
LEU A 275
 None
 1.05A 3em0B-1pujA:
undetectable		 3em0B-1pujA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 LEU A 210
TYR A 256
ALA A 240
GLY A 242
LEU A 227
 None
 1.13A 3ou7B-1pujA:
undetectable		 3ou7B-1pujA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		4 / 7 LEU A  21
LEU A 124
GLU A  29
ILE A 126
 None
 0.96A 3s56B-1pujA:
undetectable		 3s56B-1pujA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 LEU A  30
LEU A  56
LEU A  83
GLN A  95
VAL A  97
 None
 1.25A 3zqtA-1pujA:
undetectable		 3zqtA-1pujA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 10 SER A 100
ALA A  99
ILE A  54
LEU A 136
ILE A  85
 None
 1.06A 4dt8B-1pujA:
undetectable		 4dt8B-1pujA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 GLY A 127
GLY A 174
ASP A 171
LEU A 176
VAL A 131
 None
GNP  A 501 (-3.1A)
MG  A9001 ( 4.2A)
None
GNP  A 501 (-4.2A)
 0.96A 4fr0A-1pujA:
2.0		 4fr0A-1pujA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 ILE A  85
LEU A  93
VAL A 163
ILE A 125
LEU A 169
 None
 1.10A 5ienA-1pujA:
undetectable		 5ienA-1pujA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 10 ILE A  85
LEU A  93
VAL A 163
ILE A 125
LEU A 169
 None
 1.15A 5ienB-1pujA:
undetectable		 5ienB-1pujA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		5 / 12 ALA A 240
ILE A  35
GLY A 193
PHE A 272
THR A 259
 None
 1.01A 5jlcA-1pujA:
undetectable		 5jlcA-1pujA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		3 / 3 LYS A 271
LEU A 221
ILE A 263
 None
 0.77A 5kc0A-1pujA:
undetectable		 5kc0A-1pujA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1puj CONSERVED
HYPOTHETICAL PROTEIN
YLQF
(Bacillus
subtilis) 		3 / 3 LEU A 189
ALA A 190
LEU A 176
 None
 0.45A 5uunB-1pujA:
undetectable		 5uunB-1pujA:
22.46