SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 SER A 281
GLY A 285
HIS A 291
ILE A 310
 None
 0.95A 1gtnF-1pv9A:
0.4
1gtnG-1pv9A:
0.4		 1gtnF-1pv9A:
13.24
1gtnG-1pv9A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 SER A 281
GLY A 285
HIS A 291
ILE A 310
 None
 0.93A 1gtnJ-1pv9A:
0.3
1gtnK-1pv9A:
0.4		 1gtnJ-1pv9A:
13.24
1gtnK-1pv9A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 PHE A  21
ILE A 114
LYS A  24
ALA A  23
 None
 1.15A 1hk2A-1pv9A:
undetectable		 1hk2A-1pv9A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 VAL A 164
ILE A 148
THR A 343
ILE A 221
LEU A 210
 None
 1.10A 1z11C-1pv9A:
0.0		 1z11C-1pv9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 VAL A 164
ILE A 148
THR A 343
ILE A 221
LEU A 210
 None
 1.10A 1z11D-1pv9A:
0.0		 1z11D-1pv9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 210
ALA A 177
ILE A 139
ALA A 143
ASP A 209
 None
None
None
None
ZN  A 402 (-2.2A)
 1.23A 2ejtA-1pv9A:
undetectable		 2ejtA-1pv9A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 ILE A 310
ILE A 312
ARG A 247
ILE A 332
 None
 0.71A 2nniA-1pv9A:
undetectable		 2nniA-1pv9A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 GLY A  92
ASP A 116
VAL A 117
GLY A  89
ILE A 118
 None
 0.90A 2r5pB-1pv9A:
undetectable		 2r5pB-1pv9A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 LEU A 210
ALA A 177
ILE A 139
ALA A 143
ASP A 209
 None
None
None
None
ZN  A 402 (-2.2A)
 1.16A 3axtA-1pv9A:
undetectable		 3axtA-1pv9A:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		4 / 4 ILE A 221
GLN A 245
ILE A 208
LEU A 282
 None
 1.15A 3dzyD-1pv9A:
0.2		 3dzyD-1pv9A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 10 GLY A 228
ASP A 204
VAL A 206
ILE A 200
ILE A 225
 None
 0.82A 3ekpD-1pv9A:
undetectable		 3ekpD-1pv9A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 GLY A 323
ILE A 240
VAL A 241
 None
 0.38A 3nv6A-1pv9A:
undetectable		 3nv6A-1pv9A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		6 / 12 LEU A 261
GLY A 336
ALA A 337
GLY A 307
PRO A 294
ILE A 296
 None
 1.36A 3s54A-1pv9A:
undetectable		 3s54A-1pv9A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		4 / 8 ALA A 177
PHE A 178
ALA A 140
THR A 341
 None
ZN  A 402 ( 4.8A)
None
None
 0.90A 3t3sD-1pv9A:
undetectable		 3t3sD-1pv9A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 PRO A 294
ILE A 312
LEU A 282
ALA A 265
ILE A 332
 None
 1.05A 3vrmA-1pv9A:
0.0		 3vrmA-1pv9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 8 ILE A  81
ILE A  78
PHE A  72
SER A  32
GLY A  40
 None
 1.40A 4ac9C-1pv9A:
undetectable		 4ac9C-1pv9A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 ASP A 179
HIS A 284
HIS A 291
ASP A 220
PRO A 176
 None
ZN  A 401 (-3.3A)
None
ZN  A 402 ( 2.4A)
None
 1.33A 4bz6A-1pv9A:
undetectable
4bz6B-1pv9A:
undetectable		 4bz6A-1pv9A:
22.17
4bz6B-1pv9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA503_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		4 / 6 ARG A 235
ILE A 237
VAL A 324
LEU A 205
 None
 0.76A 4em2A-1pv9A:
undetectable		 4em2A-1pv9A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 7 GLY A  40
VAL A  53
PHE A  21
ILE A  78
PHE A 102
 None
 1.44A 4fglC-1pv9A:
undetectable		 4fglC-1pv9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 GLY A  92
ASP A 116
VAL A 117
GLY A  89
ILE A 118
 None
 0.96A 4njvB-1pv9A:
undetectable		 4njvB-1pv9A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_A_KANA201_1
(BIFUNCTIONAL AAC/APH)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 TYR A  29
GLY A  33
TYR A 217
GLU A 131
GLU A  64
 None
 1.30A 4qc6A-1pv9A:
0.2		 4qc6A-1pv9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_1
(BIFUNCTIONAL AAC/APH)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 TYR A  29
GLY A  33
TYR A 217
GLU A 131
GLU A  64
 None
 1.25A 4qc6B-1pv9A:
0.0		 4qc6B-1pv9A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		6 / 12 LEU A 261
GLY A 336
ALA A 337
GLY A 307
PRO A 294
ILE A 296
 None
 1.42A 5e5jB-1pv9A:
undetectable		 5e5jB-1pv9A:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 THR A 329
PRO A 294
ARG A 295
 None
 0.85A 5nd7B-1pv9A:
undetectable		 5nd7B-1pv9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 GLY A 283
HIS A 284
ASP A 220
HIS A 192
 None
ZN  A 401 (-3.3A)
ZN  A 402 ( 2.4A)
None
 0.71A 5nnwD-1pv9A:
0.0		 5nnwD-1pv9A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		4 / 7 GLY A 283
HIS A 284
ASP A 220
HIS A 192
 None
ZN  A 401 (-3.3A)
ZN  A 402 ( 2.4A)
None
 0.74A 5no9D-1pv9A:
0.0		 5no9D-1pv9A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OGC_B_TA1B601_1
(TUBULIN BETA CHAIN)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 12 VAL A  28
LEU A 213
SER A  32
GLY A  38
LEU A  37
 None
 1.27A 5ogcB-1pv9A:
undetectable		 5ogcB-1pv9A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		4 / 5 TYR A  41
TYR A  52
GLY A  40
GLY A  39
 None
 1.11A 5x7pA-1pv9A:
undetectable		 5x7pA-1pv9A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 11 GLU A 260
ALA A 248
ALA A 252
ILE A 332
VAL A 330
 None
 1.05A 5yk2A-1pv9A:
0.0		 5yk2A-1pv9A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		3 / 3 GLU A 313
LEU A 282
ARG A 266
 ZN  A 401 (-2.6A)
None
None
 0.66A 6d8fA-1pv9A:
0.0		 6d8fA-1pv9A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1pv9 XAA-PRO DIPEPTIDASE
(Pyrococcus
furiosus) 		5 / 9 ILE A 151
ILE A 148
GLU A 201
VAL A 206
ILE A 225
 None
 1.38A 6hloA-1pv9A:
undetectable		 6hloA-1pv9A:
20.04