SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pvd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 MET A 138
ALA A 145
LEU A   6
LEU A  10
 None
 0.83A 1ereE-1pvdA:
undetectable		 1ereE-1pvdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 MET A 138
ALA A 145
LEU A   6
LEU A  10
 None
 0.83A 1ereF-1pvdA:
undetectable		 1ereF-1pvdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 446
GLY A 443
GLY A 416
SER A 408
VAL A 384
 TPP  A 557 ( 2.4A)
TPP  A 557 (-3.5A)
None
None
None
 1.12A 1fduA-1pvdA:
3.0		 1fduA-1pvdA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 THR A 456
ILE A  70
ILE A  71
ILE A  64
ALA A 428
 None
 1.28A 1jtxA-1pvdA:
0.0		 1jtxA-1pvdA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 197
LYS A 327
VAL A 329
 None
 0.91A 1l2iA-1pvdA:
undetectable		 1l2iA-1pvdA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 132
ALA A  86
GLY A  87
GLU A  91
HIS A  97
 None
 1.42A 1n6cA-1pvdA:
undetectable		 1n6cA-1pvdA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 470
ASN A 471
ILE A 490
GLY A 473
 None
MG  A 558 (-2.6A)
None
MG  A 558 (-4.3A)
 1.05A 1oniA-1pvdA:
undetectable
1oniB-1pvdA:
undetectable		 1oniA-1pvdA:
14.73
1oniB-1pvdA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 470
ASN A 471
ILE A 490
GLY A 473
 None
MG  A 558 (-2.6A)
None
MG  A 558 (-4.3A)
 1.07A 1oniD-1pvdA:
undetectable
1oniF-1pvdA:
undetectable		 1oniD-1pvdA:
14.73
1oniF-1pvdA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 447
LEU A 540
MET A 539
 None
 0.84A 2itzA-1pvdA:
undetectable		 2itzA-1pvdA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 392
GLY A 413
SER A 446
 None
None
TPP  A 557 ( 2.4A)
 0.38A 2ivuA-1pvdA:
undetectable		 2ivuA-1pvdA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 495
ILE A 454
LEU A 440
 None
 0.59A 2kceA-1pvdA:
undetectable		 2kceA-1pvdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 540
LEU A 469
LEU A 440
MET A 370
 None
 1.09A 2oaxF-1pvdA:
0.0		 2oaxF-1pvdA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 540
LEU A 469
LEU A 466
MET A 370
 None
 1.05A 2oaxF-1pvdA:
0.0		 2oaxF-1pvdA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 122
PHE A  74
PHE A  29
 None
 0.83A 2od9A-1pvdA:
7.3		 2od9A-1pvdA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 122
PHE A  74
PHE A  29
 None
 0.83A 2qqgA-1pvdA:
7.3		 2qqgA-1pvdA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 441
ILE A 439
TRP A 371
GLY A 375
 None
 0.98A 2qwxA-1pvdA:
3.1
2qwxB-1pvdA:
3.0		 2qwxA-1pvdA:
18.39
2qwxB-1pvdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  59
ARG A  63
MET A 247
HIS A 225
GLY A  87
 None
 1.48A 2y6rC-1pvdA:
1.3		 2y6rC-1pvdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 420
ILE A 442
ALA A  58
ASP A  59
LEU A  52
 None
 0.88A 2yqzA-1pvdA:
3.9		 2yqzA-1pvdA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 420
ILE A 442
LEU A 423
ASP A  59
LEU A  52
 None
 0.92A 2yqzA-1pvdA:
3.9		 2yqzA-1pvdA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 385
LEU A 440
MET A 457
THR A 456
 None
 0.94A 3ag2N-1pvdA:
undetectable
3ag2W-1pvdA:
undetectable		 3ag2N-1pvdA:
21.98
3ag2W-1pvdA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 384
ARG A 534
ILE A 538
THR A 422
 None
 1.43A 3cl9A-1pvdA:
undetectable		 3cl9A-1pvdA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 103
GLY A 166
GLU A  78
VAL A  99
GLY A 100
 None
 1.06A 3f8wA-1pvdA:
undetectable		 3f8wA-1pvdA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 103
GLY A 166
GLU A  78
VAL A  99
GLY A 100
 None
 1.07A 3f8wB-1pvdA:
undetectable		 3f8wB-1pvdA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A 103
GLY A 166
GLU A  78
VAL A  99
GLY A 100
 None
 1.07A 3f8wC-1pvdA:
undetectable		 3f8wC-1pvdA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 PRO A 191
LEU A 189
GLN A 325
 None
 0.70A 3hznG-1pvdA:
undetectable
3hznH-1pvdA:
undetectable		 3hznG-1pvdA:
16.64
3hznH-1pvdA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 440
GLY A 420
ALA A 421
ASP A  59
ILE A 415
ILE A 385
 None
None
None
None
TPP  A 557 ( 3.8A)
None
 1.33A 3k4vA-1pvdA:
undetectable		 3k4vA-1pvdA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 396
ASN A 548
GLU A 368
 None
 0.91A 3kpdB-1pvdA:
0.0		 3kpdB-1pvdA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		6 / 12 LEU A 440
GLY A 420
ALA A 421
ASP A  59
ILE A 415
ILE A 385
 None
None
None
None
TPP  A 557 ( 3.8A)
None
 1.36A 3ndtA-1pvdA:
undetectable		 3ndtA-1pvdA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 160
GLY A  66
ILE A  85
ALA A  58
ALA A  55
 None
 1.02A 3sueA-1pvdA:
undetectable		 3sueA-1pvdA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 ARG A 224
GLY A 250
ALA A 287
GLY A 286
GLU A 308
 None
 1.24A 4a6nA-1pvdA:
0.9		 4a6nA-1pvdA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 527
HIS A 510
GLU A 517
TRP A 518
 None
 1.24A 4cx7A-1pvdA:
undetectable
4cx7B-1pvdA:
undetectable		 4cx7A-1pvdA:
21.04
4cx7B-1pvdA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 489
ILE A 490
ASN A 470
ASP A 472
 None
 1.13A 4d33A-1pvdA:
undetectable		 4d33A-1pvdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A  84
ASN A  83
PRO A 162
ILE A 132
 None
 0.91A 4j4vC-1pvdA:
undetectable		 4j4vC-1pvdA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 333
LEU A 330
ILE A 204
VAL A 324
 None
 0.88A 4klaA-1pvdA:
undetectable		 4klaA-1pvdA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 236
GLU A 230
VAL A 285
ALA A 218
 None
 0.91A 4nkvC-1pvdA:
undetectable		 4nkvC-1pvdA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 236
GLU A 230
VAL A 285
ALA A 218
 None
 0.91A 4nkxA-1pvdA:
0.0		 4nkxA-1pvdA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 425
GLN A 409
GLY A 413
 None
 0.62A 4odoC-1pvdA:
undetectable		 4odoC-1pvdA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 441
ILE A 439
TRP A 371
GLY A 375
 None
 0.95A 4qogA-1pvdA:
3.1
4qogB-1pvdA:
3.1		 4qogA-1pvdA:
18.39
4qogB-1pvdA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
 None
 1.11A 4qvpH-1pvdA:
undetectable
4qvpI-1pvdA:
undetectable		 4qvpH-1pvdA:
17.65
4qvpI-1pvdA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
 None
 1.11A 4qvpV-1pvdA:
undetectable
4qvpW-1pvdA:
undetectable		 4qvpV-1pvdA:
17.65
4qvpW-1pvdA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
 None
 1.14A 4qvvH-1pvdA:
undetectable		 4qvvH-1pvdA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
 None
 1.13A 4qvvV-1pvdA:
undetectable		 4qvvV-1pvdA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
 None
 1.11A 4qw0H-1pvdA:
undetectable
4qw0I-1pvdA:
undetectable		 4qw0H-1pvdA:
17.65
4qw0I-1pvdA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
 None
 1.11A 4qw0V-1pvdA:
undetectable
4qw0W-1pvdA:
undetectable		 4qw0V-1pvdA:
17.65
4qw0W-1pvdA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 TRP A 518
PHE A 527
HIS A 510
GLU A 517
 None
 1.28A 5ad9A-1pvdA:
undetectable
5ad9B-1pvdA:
undetectable		 5ad9A-1pvdA:
20.87
5ad9B-1pvdA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 443
GLY A 445
THR A 450
ASP A 444
ILE A 538
 TPP  A 557 (-3.5A)
TPP  A 557 (-3.4A)
None
MG  A 558 (-2.8A)
None
 0.93A 5bw4A-1pvdA:
3.6		 5bw4A-1pvdA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
 None
 1.13A 5cz7V-1pvdA:
undetectable
5cz7W-1pvdA:
undetectable		 5cz7V-1pvdA:
17.65
5cz7W-1pvdA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
 None
 1.14A 5d0xV-1pvdA:
undetectable		 5d0xV-1pvdA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 425
GLY A  84
GLY A 420
GLY A  94
VAL A  95
 None
 0.94A 5i71A-1pvdA:
0.0		 5i71A-1pvdA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 425
GLY A  84
GLY A 420
GLY A  94
VAL A  95
 None
 0.94A 5i73A-1pvdA:
undetectable		 5i73A-1pvdA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 425
GLY A  84
GLY A 420
GLY A  94
VAL A  95
 None
 0.94A 5i75A-1pvdA:
0.0		 5i75A-1pvdA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 383
ASP A 382
ALA A 425
PRO A 464
LEU A 466
 None
 1.35A 5syfB-1pvdA:
undetectable		 5syfB-1pvdA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 THR A 266
GLU A 277
THR A 303
LEU A 289
 None
 1.23A 5utuH-1pvdA:
undetectable		 5utuH-1pvdA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 GLU A  91
ALA A  62
GLY A  60
TYR A  56
 None
 1.09A 5uxdA-1pvdA:
0.0		 5uxdA-1pvdA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  11
ARG A  13
LEU A  14
GLN A  16
 None
 0.77A 6b89B-1pvdA:
undetectable		 6b89B-1pvdA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1pvd PYRUVATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 7 TYR A 263
VAL A 208
ILE A 216
ARG A 317
ALA A 279
 None
 1.49A 6hd6B-1pvdA:
undetectable		 6hd6B-1pvdA:
9.64