SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pvg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 9 ASN A  70
ILE A 104
PRO A 105
ILE A 120
THR A 195
 MG  A 903 ( 2.6A)
ANP  A 901 (-4.9A)
None
ANP  A 901 (-3.8A)
ANP  A 901 ( 4.2A)
 0.79A 1aj6A-1pvgA:
18.5		 1aj6A-1pvgA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		4 / 8 GLU A  51
LEU A 255
ALA A 293
THR A 278
 None
 0.88A 1ie4B-1pvgA:
undetectable
1ie4D-1pvgA:
undetectable		 1ie4B-1pvgA:
14.22
1ie4D-1pvgA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 12 ASP A  73
ILE A 104
PRO A 105
ILE A 120
THR A 195
 None
ANP  A 901 (-4.9A)
None
ANP  A 901 (-3.8A)
ANP  A 901 ( 4.2A)
 0.79A 1kijA-1pvgA:
28.5		 1kijA-1pvgA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  70
ILE A 104
PRO A 105
ALA A 146
THR A 195
 MG  A 903 ( 2.6A)
ANP  A 901 (-4.9A)
None
ANP  A 901 (-3.3A)
ANP  A 901 ( 4.2A)
 0.81A 1kijB-1pvgA:
28.8		 1kijB-1pvgA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  70
ILE A 104
PRO A 105
ILE A 120
THR A 195
 MG  A 903 ( 2.6A)
ANP  A 901 (-4.9A)
None
ANP  A 901 (-3.8A)
ANP  A 901 ( 4.2A)
 0.79A 1kijB-1pvgA:
28.8		 1kijB-1pvgA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N6C_A_SAMA402_0
(SET
DOMAIN-CONTAINING
PROTEIN 7)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 11 ILE A  67
ALA A 146
GLY A 145
ASN A 129
ASN A  70
 None
ANP  A 901 (-3.3A)
ANP  A 901 (-3.5A)
ANP  A 901 (-4.0A)
MG  A 903 ( 2.6A)
 1.31A 1n6cA-1pvgA:
undetectable		 1n6cA-1pvgA:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		7 / 7 HIS A  20
THR A  27
TYR A  28
ASN A 142
TYR A 144
LEU A 148
GLN A 365
 None
None
None
ANP  A 901 (-4.7A)
None
None
ANP  A 901 (-3.2A)
 0.18A 1qzrA-1pvgA:
62.4		 1qzrA-1pvgA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		7 / 7 HIS A  20
THR A  27
TYR A  28
ASN A 142
TYR A 144
LEU A 148
GLN A 365
 None
None
None
ANP  A 901 (-4.7A)
None
None
ANP  A 901 (-3.2A)
 0.36A 1qzrB-1pvgA:
60.3		 1qzrB-1pvgA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 304
ARG A 287
ASN A 306
 None
 0.87A 1xzxX-1pvgA:
undetectable		 1xzxX-1pvgA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 302
ALA A 309
ILE A 244
LEU A 253
THR A 311
 None
 1.01A 2w3aB-1pvgA:
undetectable		 2w3aB-1pvgA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 302
ALA A 309
ILE A 244
LEU A 253
THR A 311
 None
 1.04A 2w3mA-1pvgA:
undetectable		 2w3mA-1pvgA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 194
VAL A 170
TYR A 188
ILE A 106
 None
 1.22A 2xz5B-1pvgA:
undetectable
2xz5E-1pvgA:
undetectable		 2xz5B-1pvgA:
20.81
2xz5E-1pvgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 106
TYR A 194
VAL A 170
TYR A 188
 None
 1.24A 2xz5A-1pvgA:
undetectable
2xz5C-1pvgA:
undetectable		 2xz5A-1pvgA:
20.81
2xz5C-1pvgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 106
TYR A 194
VAL A 170
TYR A 188
 None
 1.25A 2xz5C-1pvgA:
undetectable
2xz5D-1pvgA:
undetectable		 2xz5C-1pvgA:
20.81
2xz5D-1pvgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 106
TYR A 194
VAL A 170
TYR A 188
 None
 1.23A 2xz5D-1pvgA:
undetectable
2xz5E-1pvgA:
undetectable		 2xz5D-1pvgA:
20.81
2xz5E-1pvgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 139
ILE A  67
CYH A 149
PHE A 152
GLY A 143
 None
None
None
None
ANP  A 901 (-3.3A)
 1.17A 3ko0A-1pvgA:
0.0
3ko0C-1pvgA:
undetectable		 3ko0A-1pvgA:
12.17
3ko0C-1pvgA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 143
GLY A 139
ILE A  67
CYH A 149
PHE A 152
 ANP  A 901 (-3.3A)
None
None
None
None
 1.20A 3ko0H-1pvgA:
undetectable
3ko0I-1pvgA:
0.0		 3ko0H-1pvgA:
12.17
3ko0I-1pvgA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 143
GLY A 139
ILE A  67
CYH A 149
PHE A 152
 ANP  A 901 (-3.3A)
None
None
None
None
 1.17A 3ko0L-1pvgA:
undetectable
3ko0N-1pvgA:
undetectable		 3ko0L-1pvgA:
12.17
3ko0N-1pvgA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 139
ILE A  67
CYH A 149
PHE A 152
GLY A 143
 None
None
None
None
ANP  A 901 (-3.3A)
 1.19A 3ko0R-1pvgA:
0.0
3ko0T-1pvgA:
undetectable		 3ko0R-1pvgA:
12.17
3ko0T-1pvgA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 171
TYR A 169
GLN A 167
ILE A 106
 None
 0.96A 3peoG-1pvgA:
undetectable		 3peoG-1pvgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 122
GLU A 118
GLN A 171
ASP A  73
ASN A 150
 None
 1.31A 3qowA-1pvgA:
undetectable		 3qowA-1pvgA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 316
SER A 379
ASN A 306
 None
 0.80A 3s8pB-1pvgA:
undetectable		 3s8pB-1pvgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 194
VAL A 170
TYR A 188
ILE A 106
 None
 1.23A 4bqtC-1pvgA:
0.7
4bqtD-1pvgA:
undetectable		 4bqtC-1pvgA:
20.81
4bqtD-1pvgA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 362
ASN A 142
GLY A 140
THR A 138
 None
ANP  A 901 (-4.7A)
ANP  A 901 (-3.4A)
None
 1.00A 4ejjB-1pvgA:
0.0		 4ejjB-1pvgA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KEB_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 302
ALA A 309
ILE A 244
LEU A 253
THR A 311
 None
 1.03A 4kebB-1pvgA:
undetectable		 4kebB-1pvgA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 146
GLY A 145
ASP A  65
ILE A 120
GLY A 122
 ANP  A 901 (-3.3A)
ANP  A 901 (-3.5A)
None
ANP  A 901 (-3.8A)
None
 0.90A 4obwB-1pvgA:
undetectable		 4obwB-1pvgA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 242
GLY A 239
ASN A  87
VAL A 223
LEU A  68
 None
 1.10A 4qd3A-1pvgA:
undetectable		 4qd3A-1pvgA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		3 / 3 HIS A 316
SER A 379
ASN A 306
 None
 0.78A 5cprB-1pvgA:
0.0		 5cprB-1pvgA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 7 PHE A 377
GLY A 313
THR A 310
ILE A 357
VAL A 305
 None
 1.25A 5ik1A-1pvgA:
undetectable		 5ik1A-1pvgA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1pvg DNA TOPOISOMERASE II
(Saccharomyces
cerevisiae) 		5 / 11 VAL A  86
VAL A  69
LEU A  68
PHE A 199
VAL A 197
 None
 1.33A 6dryA-1pvgA:
undetectable		 6dryA-1pvgA:
21.21