SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pvh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_D_AG2D7015_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 1pvh LEUKEMIA INHIBITORY
FACTOR
(Homo
sapiens) 		4 / 7 LEU B 126
LEU B  83
LEU B  90
GLY B  91
 None
 0.81A 1n13D-1pvhB:
undetectable
1n13E-1pvhB:
undetectable		 1n13D-1pvhB:
22.29
1n13E-1pvhB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 1pvh LEUKEMIA INHIBITORY
FACTOR
(Homo
sapiens) 		4 / 8 PHE B  67
LEU B  90
TYR B  89
LEU B 166
 None
 1.00A 2bfpB-1pvhB:
undetectable		 2bfpB-1pvhB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1pvh LEUKEMIA INHIBITORY
FACTOR
(Homo
sapiens) 		5 / 12 THR B 145
GLY B  91
THR B  92
GLY B 147
LEU B  30
 None
 1.01A 2y7hB-1pvhB:
undetectable		 2y7hB-1pvhB:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1pvh LEUKEMIA INHIBITORY
FACTOR
(Homo
sapiens) 		5 / 12 THR B 145
GLY B  91
THR B  92
GLY B 147
LEU B  30
 None
 1.01A 2y7hC-1pvhB:
undetectable		 2y7hC-1pvhB:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1pvh INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		4 / 6 ASN A 201
GLU A 116
LYS A 199
ASN A 115
 None
 1.46A 3kp6A-1pvhA:
undetectable
3kp6B-1pvhA:
0.0		 3kp6A-1pvhA:
22.48
3kp6B-1pvhA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 1pvh LEUKEMIA INHIBITORY
FACTOR
(Homo
sapiens) 		4 / 5 LEU B  80
LEU B  83
LEU B 126
SER B 127
 None
 0.78A 3vhuA-1pvhB:
undetectable		 3vhuA-1pvhB:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1pvh LEUKEMIA INHIBITORY
FACTOR
(Homo
sapiens) 		5 / 7 GLU B  82
LYS B  79
LEU B  83
ARG B  27
LEU B  30
 None
 1.44A 4wg0B-1pvhB:
undetectable
4wg0C-1pvhB:
undetectable		 4wg0B-1pvhB:
8.33
4wg0C-1pvhB:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1pvh INTERLEUKIN-6
RECEPTOR BETA CHAIN
(Homo
sapiens) 		4 / 6 PHE A 147
PHE A 136
VAL A 162
ASP A 149
 None
 1.23A 5hesA-1pvhA:
undetectable		 5hesA-1pvhA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 1pvh LEUKEMIA INHIBITORY
FACTOR
(Homo
sapiens) 		4 / 6 GLY B  91
THR B  92
SER B  93
GLY B 147
 None
 0.82A 5k4pA-1pvhB:
undetectable		 5k4pA-1pvhB:
17.34