SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pvj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 ILE A 261
LEU A 264
VAL A 268
 None
 0.40A 1mz9B-1pvjA:
undetectable		 1mz9B-1pvjA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		5 / 10 GLY A 365
VAL A 355
MET A 121
TYR A 124
GLY A 102
 None
 1.49A 1pn0C-1pvjA:
0.0		 1pn0C-1pvjA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 LEU A 152
HIS A 204
ILE A 200
 None
 0.55A 1s9pB-1pvjA:
0.0		 1s9pB-1pvjA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		4 / 5 ALA A 260
TYR A 240
ILE A 245
ASP A 267
 None
 1.15A 1upfC-1pvjA:
undetectable		 1upfC-1pvjA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		4 / 8 MET A 274
SER A 271
TYR A 216
TYR A 276
 None
 1.19A 2bteA-1pvjA:
undetectable		 2bteA-1pvjA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		4 / 8 MET A 274
SER A 271
TYR A 216
TYR A 276
 None
 1.24A 2v0gA-1pvjA:
undetectable		 2v0gA-1pvjA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 PRO A 207
GLY A 210
TYR A 240
 None
 0.67A 2vouA-1pvjA:
undetectable		 2vouA-1pvjA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 PRO A 207
GLY A 210
TYR A 240
 None
 0.62A 2vouB-1pvjA:
undetectable		 2vouB-1pvjA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 PRO A 207
GLY A 210
TYR A 240
 None
 0.62A 2vouC-1pvjA:
undetectable		 2vouC-1pvjA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		5 / 12 HIS A 159
GLY A 365
ASP A 154
GLY A 102
ASP A 364
 None
 0.80A 3bwcB-1pvjA:
undetectable		 3bwcB-1pvjA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		4 / 6 VAL A 394
VAL A 288
ILE A 200
ARG A 307
 None
 1.12A 3mssA-1pvjA:
undetectable		 3mssA-1pvjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		4 / 6 VAL A 394
VAL A 288
ILE A 200
ARG A 307
 None
 1.10A 3mssC-1pvjA:
undetectable		 3mssC-1pvjA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		5 / 12 LEU A 369
LEU A 372
GLY A 333
GLN A 390
SER A 123
 None
 1.27A 3tbgA-1pvjA:
undetectable		 3tbgA-1pvjA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		5 / 12 LEU A 369
LEU A 372
GLY A 333
GLN A 390
SER A 123
 None
 1.30A 3tbgC-1pvjA:
undetectable		 3tbgC-1pvjA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		4 / 7 LEU A 231
GLY A 277
TYR A 276
SER A 280
 None
None
None
ZFB  A 450 (-4.7A)
 0.94A 4cp3A-1pvjA:
undetectable
4cp3B-1pvjA:
undetectable		 4cp3A-1pvjA:
15.24
4cp3B-1pvjA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		5 / 12 SER A 280
TYR A 276
ALA A 233
ILE A 261
GLY A 191
 ZFB  A 450 (-4.7A)
None
None
None
ZFB  A 450 ( 4.1A)
 1.24A 4iilA-1pvjA:
undetectable		 4iilA-1pvjA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 ASP A 154
HIS A 354
LYS A 150
 None
 0.54A 4qzuD-1pvjA:
0.0		 4qzuD-1pvjA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		4 / 7 ILE A 200
HIS A 204
LEU A 292
GLY A 395
 None
 1.00A 4z69A-1pvjA:
undetectable		 4z69A-1pvjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 THR A 105
SER A 104
TYR A 103
 None
 0.66A 5jsdA-1pvjA:
undetectable		 5jsdA-1pvjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 VAL A 337
GLU A 126
GLU A 122
 ZFB  A 450 (-3.9A)
None
None
 0.81A 5jsdB-1pvjA:
0.0
5jsdC-1pvjA:
0.0		 5jsdB-1pvjA:
20.62
5jsdC-1pvjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 THR A 105
SER A 104
TYR A 103
 None
 0.66A 5jsdB-1pvjA:
undetectable		 5jsdB-1pvjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 THR A 105
SER A 104
TYR A 103
 None
 0.65A 5jsdC-1pvjA:
undetectable		 5jsdC-1pvjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 THR A 105
SER A 104
TYR A 103
 None
 0.66A 5jseA-1pvjA:
0.0		 5jseA-1pvjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 THR A 105
SER A 104
TYR A 103
 None
 0.65A 5jseB-1pvjA:
undetectable		 5jseB-1pvjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		3 / 3 THR A 105
SER A 104
TYR A 103
 None
 0.65A 5jseC-1pvjA:
0.0		 5jseC-1pvjA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		4 / 8 GLU A 180
PRO A 223
GLY A 277
PRO A 278
 None
 0.98A 5kf8A-1pvjA:
undetectable		 5kf8A-1pvjA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		4 / 8 ILE A 261
THR A 190
LEU A 169
THR A 170
 None
 0.77A 5og9A-1pvjA:
0.0		 5og9A-1pvjA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1pvj PYROGENIC EXOTOXIN B
(Streptococcus
pyogenes) 		4 / 8 HIS A 354
ASP A 345
THR A 195
ASP A 154
 None
 1.20A 5t8sB-1pvjA:
undetectable		 5t8sB-1pvjA:
23.16