SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pvl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1pvl LEUCOCIDIN
(Staphylococcus
aureus) 		3 / 3 THR A 273
ASP A 154
SER A 152
 None
 0.68A 2nxeA-1pvlA:
undetectable		 2nxeA-1pvlA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1pvl LEUCOCIDIN
(Staphylococcus
aureus) 		3 / 3 THR A 273
ASP A 154
SER A 152
 None
 0.68A 2nxeB-1pvlA:
undetectable		 2nxeB-1pvlA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 1pvl LEUCOCIDIN
(Staphylococcus
aureus) 		4 / 8 SER A  45
TYR A 118
SER A 117
THR A  50
 None
 1.20A 2v0zO-1pvlA:
undetectable		 2v0zO-1pvlA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1pvl LEUCOCIDIN
(Staphylococcus
aureus) 		3 / 3 PHE A  40
VAL A 114
ILE A 122
 None
 0.60A 4emaA-1pvlA:
undetectable		 4emaA-1pvlA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1pvl LEUCOCIDIN
(Staphylococcus
aureus) 		4 / 5 GLY A 180
MET A 192
ASN A 190
GLU A 167
 None
 1.28A 4fglC-1pvlA:
undetectable		 4fglC-1pvlA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1pvl LEUCOCIDIN
(Staphylococcus
aureus) 		4 / 8 ARG A 271
ASP A 165
SER A 152
ARG A 181
 None
 1.01A 4lv9A-1pvlA:
undetectable
4lv9B-1pvlA:
undetectable		 4lv9A-1pvlA:
20.90
4lv9B-1pvlA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1pvl LEUCOCIDIN
(Staphylococcus
aureus) 		3 / 3 ASP A 291
ASP A  89
ASN A 158
 None
 0.80A 6gngB-1pvlA:
undetectable		 6gngB-1pvlA:
17.38