SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pvt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		4 / 8 LEU A 188
ALA A 196
ILE A 210
VAL A 194
 None
 0.78A 1d4sB-1pvtA:
undetectable		 1d4sB-1pvtA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		4 / 5 GLY A 174
ILE A 107
TRP A 189
VAL A 163
 None
 1.17A 1rs7A-1pvtA:
0.0		 1rs7A-1pvtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		3 / 3 GLY A 174
TRP A 189
VAL A 187
 None
 0.76A 3n66B-1pvtA:
undetectable		 3n66B-1pvtA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		4 / 7 ILE A 160
LEU A 142
ALA A 214
ALA A 215
 None
 0.90A 3r9tB-1pvtA:
undetectable		 3r9tB-1pvtA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		4 / 8 HIS A 123
ILE A 121
SER A  29
ILE A  60
 None
 0.97A 3sfeB-1pvtA:
undetectable
3sfeC-1pvtA:
undetectable		 3sfeB-1pvtA:
22.03
3sfeC-1pvtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		3 / 3 HIS A 104
HIS A 108
ILE A 107
 None
 0.70A 3u52A-1pvtA:
0.0
3u52C-1pvtA:
0.0		 3u52A-1pvtA:
16.47
3u52C-1pvtA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		4 / 5 GLY A 174
ILE A 107
TRP A 189
VAL A 163
 None
 1.17A 4d33A-1pvtA:
0.0		 4d33A-1pvtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		4 / 5 GLY A 174
ILE A 107
TRP A 189
VAL A 187
 None
 1.14A 4d33A-1pvtA:
0.0		 4d33A-1pvtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		4 / 5 GLY A 174
ILE A 107
TRP A 189
VAL A 163
 None
 1.16A 4d33B-1pvtA:
undetectable		 4d33B-1pvtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		4 / 5 GLY A 174
ILE A 107
TRP A 189
VAL A 187
 None
 1.13A 4d33B-1pvtA:
undetectable		 4d33B-1pvtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		4 / 6 GLY A 174
ILE A 107
TRP A 189
VAL A 187
 None
 1.13A 4d39B-1pvtA:
0.0		 4d39B-1pvtA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 ALA A 215
GLU A 216
LEU A 127
GLY A 193
LEU A 188
 None
 1.03A 5gtrA-1pvtA:
undetectable		 5gtrA-1pvtA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		3 / 3 GLY A 174
TRP A 189
VAL A 187
 None
 0.76A 5vuoB-1pvtA:
undetectable		 5vuoB-1pvtA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 LEU A  59
ILE A 121
ILE A  77
VAL A  70
ILE A   8
 None
 1.00A 6emuB-1pvtA:
undetectable		 6emuB-1pvtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		5 / 12 LEU A  59
ILE A 121
ILE A  77
VAL A  70
ILE A   8
 None
 1.01A 6emuC-1pvtA:
undetectable		 6emuC-1pvtA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 1pvt SUGAR-PHOSPHATE
ALDOLASE
(Thermotoga
maritima) 		4 / 5 ASN A  94
GLY A  38
HIS A  92
ASP A  74
 None
 1.17A 6gh9A-1pvtA:
0.0		 6gh9A-1pvtA:
15.32