SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.90A 1zzrA-1pw3A:
0.0
1zzrB-1pw3A:
0.0		 1zzrA-1pw3A:
14.01
1zzrB-1pw3A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.92A 1zzrA-1pw3A:
undetectable
1zzrB-1pw3A:
undetectable		 1zzrA-1pw3A:
14.01
1zzrB-1pw3A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.91A 1zzuA-1pw3A:
undetectable
1zzuB-1pw3A:
undetectable		 1zzuA-1pw3A:
14.01
1zzuB-1pw3A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.91A 1zzuA-1pw3A:
0.0
1zzuB-1pw3A:
0.0		 1zzuA-1pw3A:
14.01
1zzuB-1pw3A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.92A 3dqrA-1pw3A:
undetectable
3dqrB-1pw3A:
undetectable		 3dqrA-1pw3A:
13.95
3dqrB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.97A 3dqrA-1pw3A:
undetectable
3dqrB-1pw3A:
undetectable		 3dqrA-1pw3A:
13.95
3dqrB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.88A 3jx2A-1pw3A:
undetectable
3jx2B-1pw3A:
undetectable		 3jx2A-1pw3A:
13.95
3jx2B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.90A 3jx2A-1pw3A:
0.0
3jx2B-1pw3A:
0.0		 3jx2A-1pw3A:
13.95
3jx2B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.94A 3jx3A-1pw3A:
0.0
3jx3B-1pw3A:
0.0		 3jx3A-1pw3A:
13.95
3jx3B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.90A 3jx3A-1pw3A:
0.0
3jx3B-1pw3A:
0.0		 3jx3A-1pw3A:
13.95
3jx3B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.93A 3jx4A-1pw3A:
undetectable
3jx4B-1pw3A:
undetectable		 3jx4A-1pw3A:
13.95
3jx4B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.89A 3jx5A-1pw3A:
undetectable
3jx5B-1pw3A:
undetectable		 3jx5A-1pw3A:
13.95
3jx5B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.91A 3jx5A-1pw3A:
undetectable
3jx5B-1pw3A:
undetectable		 3jx5A-1pw3A:
13.95
3jx5B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.85A 3jx6A-1pw3A:
undetectable
3jx6B-1pw3A:
undetectable		 3jx6A-1pw3A:
13.95
3jx6B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.89A 3jx6A-1pw3A:
0.0
3jx6B-1pw3A:
0.0		 3jx6A-1pw3A:
13.95
3jx6B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.85A 3nljA-1pw3A:
undetectable
3nljB-1pw3A:
undetectable		 3nljA-1pw3A:
13.95
3nljB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.87A 3nljA-1pw3A:
undetectable
3nljB-1pw3A:
undetectable		 3nljA-1pw3A:
13.95
3nljB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.88A 3nlpA-1pw3A:
undetectable
3nlpB-1pw3A:
undetectable		 3nlpA-1pw3A:
13.95
3nlpB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.92A 3nlpA-1pw3A:
undetectable
3nlpB-1pw3A:
undetectable		 3nlpA-1pw3A:
13.95
3nlpB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 8 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.84A 3nlqA-1pw3A:
undetectable
3nlqB-1pw3A:
undetectable		 3nlqA-1pw3A:
13.95
3nlqB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.86A 3nlqA-1pw3A:
0.0
3nlqB-1pw3A:
0.0		 3nlqA-1pw3A:
13.95
3nlqB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.88A 3nlrA-1pw3A:
undetectable
3nlrB-1pw3A:
undetectable		 3nlrA-1pw3A:
13.95
3nlrB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 8 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.90A 3nlrA-1pw3A:
undetectable
3nlrB-1pw3A:
undetectable		 3nlrA-1pw3A:
13.95
3nlrB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.92A 4cx3A-1pw3A:
undetectable
4cx3B-1pw3A:
undetectable		 4cx3A-1pw3A:
13.95
4cx3B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.90A 4cx3A-1pw3A:
0.0
4cx3B-1pw3A:
0.0		 4cx3A-1pw3A:
13.95
4cx3B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.93A 4cx4A-1pw3A:
0.0
4cx4B-1pw3A:
0.0		 4cx4A-1pw3A:
13.95
4cx4B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.92A 4cx4A-1pw3A:
undetectable
4cx4B-1pw3A:
undetectable		 4cx4A-1pw3A:
13.95
4cx4B-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 8 SER A  22
THR A  24
SER A  70
SER A  72
 None
 0.98A 4ikkA-1pw3A:
4.0
4ikkB-1pw3A:
undetectable		 4ikkA-1pw3A:
21.05
4ikkB-1pw3A:
21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ACL_A_SASA1111_1
(MCG)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		5 / 7 TYR A  32
TYR A  36
TYR A  49
GLU A  50
PRO A  55
 None
 0.76A 5aclA-1pw3A:
19.5		 5aclA-1pw3A:
60.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.84A 5addA-1pw3A:
undetectable
5addB-1pw3A:
undetectable		 5addA-1pw3A:
13.95
5addB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.83A 5adeA-1pw3A:
undetectable
5adeB-1pw3A:
undetectable		 5adeA-1pw3A:
13.95
5adeB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 VAL A 106
ARG A  61
VAL A  19
GLU A  83
 None
 0.90A 5g0pA-1pw3A:
undetectable
5g0pB-1pw3A:
undetectable		 5g0pA-1pw3A:
13.95
5g0pB-1pw3A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1pw3 IMMUNOGLOBULIN
LAMBDA CHAIN
VARIABLE REGION
(Homo
sapiens) 		4 / 7 GLU A  83
VAL A 106
ARG A  61
VAL A  19
 None
 0.92A 5g0pA-1pw3A:
undetectable
5g0pB-1pw3A:
undetectable		 5g0pA-1pw3A:
13.95
5g0pB-1pw3A:
13.95