SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pw4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 7 TYR A  42
SER A 397
TYR A  76
TRP A 138
 None
 1.32A 1eiiA-1pw4A:
undetectable		 1eiiA-1pw4A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		5 / 12 ILE A 403
GLY A 416
VAL A 419
GLY A 271
LEU A 280
 None
 1.13A 1kiaC-1pw4A:
undetectable		 1kiaC-1pw4A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 8 ILE A 357
LEU A 268
MET A 418
GLY A 416
 None
 0.98A 1os6A-1pw4A:
undetectable		 1os6A-1pw4A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_0
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		5 / 12 TYR A 300
ILE A 357
GLY A 358
GLY A 302
ILE A 355
 None
 0.85A 2fk8A-1pw4A:
undetectable		 2fk8A-1pw4A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 6 LEU A 127
LEU A  65
MET A 123
MET A 110
 None
 1.29A 2kuhA-1pw4A:
undetectable		 2kuhA-1pw4A:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 6 LEU A 268
LEU A 267
ILE A 357
ARG A 269
 None
 0.97A 2rlfA-1pw4A:
0.0
2rlfB-1pw4A:
0.0		 2rlfA-1pw4A:
7.08
2rlfB-1pw4A:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		5 / 11 MET A 329
VAL A 356
GLY A 358
ILE A 334
ALA A 335
 None
 1.03A 2yy8A-1pw4A:
undetectable
2yy8B-1pw4A:
undetectable		 2yy8A-1pw4A:
17.79
2yy8B-1pw4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 8 HIS A 165
ASN A 166
TYR A 362
ARG A 269
 None
 1.29A 3ccfB-1pw4A:
undetectable		 3ccfB-1pw4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 5 PRO A 277
THR A 407
VAL A 408
GLY A 405
 None
 1.10A 3elzA-1pw4A:
0.0		 3elzA-1pw4A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 6 SER A 292
PHE A 176
TYR A  54
PRO A 193
 None
 1.48A 3jqaB-1pw4A:
undetectable		 3jqaB-1pw4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 6 SER A 292
PHE A 176
TYR A  54
PRO A 193
 None
 1.50A 3jqaD-1pw4A:
undetectable		 3jqaD-1pw4A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 8 TYR A 266
GLY A 423
ALA A 427
ILE A 368
 None
 0.84A 3jusB-1pw4A:
undetectable		 3jusB-1pw4A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		5 / 12 TYR A 266
TYR A 270
THR A 306
ILE A 368
MET A 329
 None
 1.21A 3ld6A-1pw4A:
0.0		 3ld6A-1pw4A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 8 ILE A 357
LEU A 268
MET A 418
GLY A 416
 None
 0.97A 3selX-1pw4A:
undetectable		 3selX-1pw4A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 5 ALA A 194
PRO A 193
TYR A 191
ALA A 189
 None
 1.36A 3twpD-1pw4A:
undetectable		 3twpD-1pw4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 4 ASP A 274
THR A 278
VAL A 404
SER A 276
 None
 1.49A 3wxoA-1pw4A:
0.0		 3wxoA-1pw4A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 5 ILE A  34
HIS A 147
MET A 145
ARG A  27
 None
 1.29A 4acaB-1pw4A:
undetectable
4acaC-1pw4A:
undetectable		 4acaB-1pw4A:
22.63
4acaC-1pw4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 4 ILE A  34
HIS A 147
MET A 145
ARG A  27
 None
 1.30A 4acbB-1pw4A:
0.0
4acbC-1pw4A:
0.0		 4acbB-1pw4A:
22.63
4acbC-1pw4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 8 ASN A  47
PHE A  48
ILE A  72
ALA A 103
 None
 1.01A 4eyzA-1pw4A:
undetectable		 4eyzA-1pw4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 8 ASN A  47
PHE A  48
ILE A  72
ALA A 103
 None
 1.02A 4eyzB-1pw4A:
undetectable		 4eyzB-1pw4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 7 ILE A 357
LEU A 268
MET A 418
GLY A 416
 None
 0.96A 4hajA-1pw4A:
undetectable		 4hajA-1pw4A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 7 ILE A 357
LEU A 268
MET A 418
GLY A 416
 None
 1.04A 4hbfA-1pw4A:
undetectable		 4hbfA-1pw4A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 7 ILE A 357
LEU A 268
MET A 418
GLY A 416
 None
 1.02A 4hc3A-1pw4A:
undetectable		 4hc3A-1pw4A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		5 / 11 PHE A 195
ILE A 198
LEU A  96
LEU A  43
ALA A  39
 None
 1.34A 5fctA-1pw4A:
0.0		 5fctA-1pw4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		5 / 12 PHE A 195
ILE A 198
LEU A  96
LEU A  43
ALA A  39
 None
 1.35A 5fctB-1pw4A:
0.0		 5fctB-1pw4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		3 / 3 VAL A 167
SER A 159
MET A 366
 None
 0.94A 5ikqA-1pw4A:
undetectable		 5ikqA-1pw4A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		5 / 12 SER A 313
LYS A 315
LEU A 370
LEU A 373
GLU A 374
 None
 1.20A 5nwwA-1pw4A:
undetectable		 5nwwA-1pw4A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 6 TYR A 298
TYR A 295
ASP A 350
TYR A 270
 None
 1.47A 5ov9A-1pw4A:
undetectable		 5ov9A-1pw4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		3 / 3 TRP A 340
MET A 341
ASN A 342
 None
 1.23A 5uc1B-1pw4A:
0.0		 5uc1B-1pw4A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		3 / 3 TRP A 340
MET A 341
ASN A 342
 None
 1.21A 5uc1A-1pw4A:
undetectable		 5uc1A-1pw4A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_D_HISD402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 8 GLY A 363
VAL A 428
VAL A 332
LEU A 431
 None
 0.70A 6czmD-1pw4A:
undetectable
6czmF-1pw4A:
undetectable		 6czmD-1pw4A:
22.29
6czmF-1pw4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		4 / 8 ALA A 104
GLY A  99
LEU A 100
ALA A 201
 None
 0.69A 6mdqA-1pw4A:
undetectable		 6mdqA-1pw4A:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 1pw4 GLYCEROL-3-PHOSPHATE
TRANSPORTER
(Escherichia
coli) 		5 / 11 PHE A 195
ILE A 198
LEU A  96
LEU A  43
ALA A  39
 None
 1.27A 6r2eF-1pw4A:
0.0		 6r2eF-1pw4A:
21.26