SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1pw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 ASP A  68
PHE A  40
VAL A  65
 None
 0.72A 1kijB-1pw5A:
0.0		 1kijB-1pw5A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 SER A  47
HIS A  80
ASP A 190
 None
 0.71A 2wa2B-1pw5A:
undetectable		 2wa2B-1pw5A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 GLY A 120
ASP A 161
LEU A 125
LEU A  92
TYR A 143
 None
 1.20A 2zw9B-1pw5A:
2.5		 2zw9B-1pw5A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 LEU A  33
VAL A 191
VAL A 198
ILE A   9
 None
 1.19A 3k5vA-1pw5A:
undetectable		 3k5vA-1pw5A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		3 / 4 SER A  26
GLY A 230
GLU A 235
 None
None
NDG  A 254 (-3.1A)
 0.60A 3raeA-1pw5A:
undetectable
3raeC-1pw5A:
undetectable		 3raeA-1pw5A:
20.24
3raeC-1pw5A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 LEU A  98
ALA A 162
ASP A 161
THR A 146
 None
 0.86A 3rozA-1pw5A:
3.3		 3rozA-1pw5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 LEU A  92
THR A  95
THR A 146
GLY A  74
 None
 0.95A 4eq4A-1pw5A:
undetectable		 4eq4A-1pw5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 LEU A  92
THR A  95
THR A 146
GLY A  74
 None
 0.95A 4eqlA-1pw5A:
1.5		 4eqlA-1pw5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 LEU A  92
THR A  95
THR A 146
GLY A  74
 None
 0.94A 4eqlB-1pw5A:
undetectable		 4eqlB-1pw5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 LEU A 125
LEU A 119
ILE A 109
ILE A  90
LEU A  98
 None
 1.22A 4j26B-1pw5A:
undetectable		 4j26B-1pw5A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		3 / 4 SER A  26
GLY A 230
GLU A 235
 None
None
NDG  A 254 (-3.1A)
 0.60A 4juoA-1pw5A:
undetectable
4juoC-1pw5A:
undetectable		 4juoA-1pw5A:
20.24
4juoC-1pw5A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 LEU A  92
THR A  95
THR A 146
GLY A  74
 None
 0.88A 4l39B-1pw5A:
1.5		 4l39B-1pw5A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 ASP A 213
LEU A 210
GLY A 230
GLU A 235
PHE A 246
 SO4  A 302 ( 4.7A)
None
None
NDG  A 254 (-3.1A)
None
 1.28A 4xe5A-1pw5A:
6.8		 4xe5A-1pw5A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 ILE A 165
VAL A 117
VAL A 118
LEU A 125
THR A 146
 None
 1.29A 5bykA-1pw5A:
0.2		 5bykA-1pw5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 ARG A 175
ILE A  90
ASP A 122
LEU A  93
GLY A 120
 None
 1.17A 5x66A-1pw5A:
undetectable
5x66B-1pw5A:
undetectable		 5x66A-1pw5A:
22.78
5x66B-1pw5A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1pw5 NAGD PROTEIN,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 ARG A 202
VAL A 198
PHE A   8
VAL A 223
ILE A 222
 None
 1.46A 6gsdA-1pw5A:
3.5		 6gsdA-1pw5A:
14.58